HitPredict

Interactor 1: ACTY (P42025)
Beta-centractin (Actin-related protein 1B) (ARP1B)
Gene: ACTR1B

Interactor 2: DCTN1 (Q14203)
Dynactin subunit 1 (150 kDa dynein-associated polypeptide) (DAP-150) (DP-150) (p135) (p150-glued)
Gene: DCTN1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	0.60	0.714

Property	Details
Experiments	26186194, 26638075, 28514442, 33961781, 12857853
Identification Methods	affinity chromatography technology, proximity labelling technology, cosedimentation through density gradient, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005813 - centrosome GO:0005829 - cytosol GO:0015630 - microtubule cytoskeleton GO:0016020 - membrane
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 376 Hs			1 1278
+	Hs
		897056 ACTZ_HUMAN (1-376): 0: 728: 90.43		DCTN1_HUMAN (1-1278): 1.48e-90: 322: 100.00
+	Dm
		528047 ACTZ_DROME (1-376): 0: 641: 77.13		DCTN1_DROME (23-1233): 4.05e-103: 358: 31.82
+	Hs
		891760 ACTB_HUMAN (8-376): 0: 581: 53.62		DCTN1_HUMAN (1-1278): 1.48e-90: 322: 100.00
+	Hs
		929862 ACTG_HUMAN (7-376): 0: 581: 53.74		DCTN1_HUMAN (1-1278): 1.48e-90: 322: 100.00
+	Hs
		932151 ACTC_HUMAN (5-376): 0: 577: 53.72		DCTN1_HUMAN (1-1278): 1.48e-90: 322: 100.00
+	Hs
		915383 ACTA_HUMAN (5-376): 0: 576: 53.46		DCTN1_HUMAN (1-1278): 1.48e-90: 322: 100.00
+	Hs
		675128 ACTY_HUMAN (1-376): 0: 776: 100.00		CLIP1_HUMAN (111-828): 1.9e-21: 103: 11.32
+	Hs
		675146 ACTZ_HUMAN (1-376): 0: 728: 90.43		CLIP1_HUMAN (111-828): 1.9e-21: 103: 11.32
+	Rn
		892236 ACTB_RAT (8-376): 0: 581: 53.62		MYH10_RAT (664-1275): 1.11e-22: 107: 10.46
+	Hs
		725136 ACTC_HUMAN (5-376): 0: 577: 53.72		MYH10_HUMAN (664-1275): 2.12e-23: 110: 10.13
+	Hs
		725135 ACTH_HUMAN (7-376): 0: 573: 53.74		MYH10_HUMAN (664-1275): 2.12e-23: 110: 10.13
+	Hs
		724738 ACTB_HUMAN (8-376): 0: 581: 53.62		MYH9_HUMAN (805-1271): 6.9e-15: 82.5: 11.54
+	Hs
		724762 ACTG_HUMAN (7-376): 0: 581: 53.74		MYH9_HUMAN (805-1271): 6.9e-15: 82.5: 11.54
+	Mm
		892205 ACTB_MOUSE (8-376): 0: 581: 53.62		MYH9_MOUSE (826-1275): 8.37e-15: 82.2: 10.13
+	Rn
		892228 ACTB_RAT (8-376): 0: 581: 53.62		MYH9_RAT (805-1277): 3.43e-14: 80.2: 12.76
+	Hs
		724766 ACTC_HUMAN (5-376): 0: 577: 53.72		MYH9_HUMAN (805-1271): 6.9e-15: 82.5: 11.54
+	Hs
		724767 ACTS_HUMAN (5-376): 0: 576: 53.19		MYH9_HUMAN (805-1271): 6.9e-15: 82.5: 11.54
+	Ce
		91038 Q9NA98_CAEEL (4-376): 0: 545: 67.56		E2JKZ0_CAEEL (42-637): 2.46e-12: 73.9: 15.00