HitPredict

Interactor 1: GRIA1 (P42261)
Glutamate receptor 1 (GluR-1) (AMPA-selective glutamate receptor 1) (GluR-A) (GluR-K1) (Glutamate receptor ionotropic, AMPA 1)
Gene: GRIA1

Interactor 2: KCC2A (Q9UQM7)
Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17)
Gene: CAMK2A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	24706758
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0014069 - postsynaptic density GO:0030666 - endocytic vesicle membrane GO:0035254 - glutamate receptor binding GO:0043197 - dendritic spine
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 906 Hs			1 478
+	Rn
		506693 GRIA1_RAT (1-906): 0: 942: 97.91		KCC2A_RAT (1-478): 0: 566: 99.79
+	Hs
		816227 GRIA4_HUMAN (6-906): 0: 855: 66.52		KCC2A_HUMAN (1-478): 0: 565: 100.00
+	Rn
		514948 GRIA4_RAT (6-906): 0: 856: 67.18		KCC2G_RAT (1-476): 0: 522: 76.00
+	Mm
		515217 NMDZ1_MOUSE (2-888): 0: 580: 22.08		KCC2A_MOUSE (1-478): 0: 566: 99.79
+	Hs
		984288 NMDZ1_HUMAN (2-888): 0: 576: 21.77		KCC2A_HUMAN (1-478): 0: 565: 100.00
+	Mm
		659456 GRID2_MOUSE (1-895): 0: 600: 24.71		KCC2B_MOUSE (1-476): 6.17e-179: 514: 71.11
+	Mm
		659444 NMDZ1_MOUSE (2-888): 0: 580: 22.08		KCC2B_MOUSE (1-476): 6.17e-179: 514: 71.11
+	Hs
		984259 NMDZ1_HUMAN (2-888): 0: 576: 21.77		KCC2G_HUMAN (276-475): 3.97e-45: 167: 53.50