Interactor 1: AK1C3 (P42330)
Aldo-keto reductase family 1 member C3 (EC 1.1.1.-) (EC 1.1.1.210) (EC 1.1.1.53) (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase type 5) (17-beta-HSD 5) (3-alpha-HSD type II, brain) (3-alpha-hydroxysteroid dehydrogenase type 2) (3-alpha-HSD type 2) (EC 1.1.1.357) (Chlordecone reductase homolog HAKRb) (Dihydrodiol dehydrogenase 3) (DD-3) (DD3) (Dihydrodiol dehydrogenase type I) (HA1753) (Prostaglandin F synthase) (PGFS) (EC 1.1.1.188) (Testosterone 17-beta-dehydrogenase 5) (EC 1.1.1.239, EC 1.1.1.64)
Gene: AKR1C3

Interactor 2: AK1D1 (P51857)
Aldo-keto reductase family 1 member D1 (EC 1.3.1.3) (3-oxo-5-beta-steroid 4-dehydrogenase) (Delta(4)-3-ketosteroid 5-beta-reductase) (Delta(4)-3-oxosteroid 5-beta-reductase)
Gene: AKR1D1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.74 1.00 0.861

The method score is based on:

Property Details
Experiments 26186194, 28514442, 33961781
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Aldo_ket_red~Aldo_ket_red
Common GO terms GO:0004032 - aldose reductase (NADPH) activity
GO:0004033 - aldo-keto reductase (NADPH) activity
GO:0005829 - cytosol
GO:0047086 - ketosteroid monooxygenase activity
GO:0047787 - Delta4-3-oxosteroid 5beta-reductase activity
Homologous interactions 11

Homologous interactions

Color coding for hit scores

1 323
Hs

1 326
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Last updated: 15 Jul 2024