HitPredict

Interactor 1: MTOR (P42345)
Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin and FKBP12 target 1) (Rapamycin target protein 1)
Gene: MTOR

Interactor 2: TRAF2 (Q12933)
TNF receptor-associated factor 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF2) (RING-type E3 ubiquitin transferase TRAF2) (Tumor necrosis factor type 2 receptor-associated protein 3)
Gene: TRAF2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	14743216
Identification Methods	tandem affinity purification
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0030163 - protein catabolic process
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 2549 Hs			1 501
+	Hs
		787613 MTOR_HUMAN (1-2549): 0: 2102: 100.00		TRAF6_HUMAN (2-498): 5.24e-109: 335: 27.08
+	Mm
		936284 MTOR_MOUSE (1-2549): 0: 2095: 98.94		TRAF6_MOUSE (2-498): 2.51e-110: 339: 27.87
+	Hs
		1031649 ATM_HUMAN (387-2548): 0: 894: 14.98		TRAF6_HUMAN (2-498): 5.24e-109: 335: 27.08
+	Hs
		1313389 TRRAP_HUMAN (925-2548): 0: 720: 15.53		TRAF4_HUMAN (17-498): 1.52e-94: 296: 29.12
+	Hs
		585100 TRRAP_HUMAN (925-2548): 0: 720: 15.53		RO52_HUMAN (28-368): 2.44e-56: 196: 12.68
+	Hs
		1297114 TRRAP_HUMAN (925-2548): 0: 720: 15.53		TRI47_HUMAN (32-345): 1.6e-44: 167: 15.84
+	Hs
		944236 PRKDC_HUMAN (695-2548): 0: 686: 14.83		TRI25_HUMAN (27-347): 1.26e-39: 153: 12.95
+	Hs
		1268288 GCN1_HUMAN (245-1372): 1.05e-38: 162: 12.17		TRAF6_HUMAN (2-498): 5.24e-109: 335: 27.08