Protein: TGFR1
TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Activin A receptor type II-like protein kinase of 53kD) (Activin receptor-like kinase 5) (ALK-5) (ALK5) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)

Gene: TGFR1, TGFBR1
Organism: Homo sapiens
Interactions: 175
UniProt ID: P36897

Gene Ontology (top 5):
GO:0001501 - skeletal system development
GO:0001701 - in utero embryonic development
GO:0001822 - kidney development
GO:0001824 - blastocyst development
GO:0001837 - epithelial to mesenchymal transition

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

787357

TGFR2
TGF-beta receptor type-2

13

20

Small-scale

0.977

High

787373

FKB1A
Peptidyl-prolyl cis-trans isomerase FKBP1A

6

7

Small-scale

0.944

High

376739

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

6

20

Small-scale

0.935

High

528388

TGFB3
Transforming growth factor beta-3 proprotein [Cleaved into: Latency-associated peptide

3

20

Small-scale

0.858

High

461221

HS90A
Heat shock protein HSP 90-alpha

3

16

Small-scale

0.857

High

787396

BMPR2
Bone morphogenetic protein receptor type-2

3

19

Small-scale

0.828

High

213841

M3K7
Mitogen-activated protein kinase kinase kinase 7

3

19

Small-scale

0.827

High

787356

ACVL1
Activin receptor type-1-like

2

19

Small-scale

0.776

High

787395

AVR2B
Activin receptor type-2B

2

19

High-throughput

0.776

High

177659

SMAD7
Mothers against decapentaplegic homolog 7

19

20

Small-scale

0.763

High

787369

CDC42
Cell division control protein 42 homolog

2

20

Small-scale

0.754

High

787401

SMAD2
Mothers against decapentaplegic homolog 2

10

20

Small-scale

0.752

High

787450

SMUF2
E3 ubiquitin-protein ligase SMURF2

8

19

Small-scale

0.741

High

608227

EGLN
Endoglin

6

12

Small-scale

0.736

High

787391

PAK1
Serine/threonine-protein kinase PAK 1

1

6

Small-scale

0.724

High

787475

TRAF6
TNF receptor-associated factor 6

5

6

Small-scale

0.720

High

787379

SMAD3
Mothers against decapentaplegic homolog 3

5

20

Small-scale

0.714

High

388858

A2GL
Leucine-rich alpha-2-glycoprotein

1

20

Small-scale

0.692

High

520766

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

2

High-throughput

0.691

High

607349

HLAG
HLA class I histocompatibility antigen, alpha chain G

1

2

High-throughput

0.691

High

710102

EPHA2
Ephrin type-A receptor 2

1

20

High-throughput

0.691

High

787427

ACV1C
Activin receptor type-1C

1

19

High-throughput

0.691

High

787477

GPR45
Probable G-protein coupled receptor 45

1

3

High-throughput

0.691

High

787464

DP13A
DCC-interacting protein 13-alpha

1

0

Small-scale

0.687

High

698443

CALX
Calnexin

4

7

High-throughput

0.683

High

787378

FKB1B
Peptidyl-prolyl cis-trans isomerase FKBP1B

1

7

Small-scale

0.680

High

787474

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

4

15

Small-scale

0.676

High

787461

M3K20
Mitogen-activated protein kinase kinase kinase 20

1

18

Small-scale

0.665

High

787386

TYRO3
Tyrosine-protein kinase receptor TYRO3

1

14

High-throughput

0.646

High

787451

SMUF1
E3 ubiquitin-protein ligase SMURF1

3

19

Small-scale

0.640

High

787473

STRAP
Serine-threonine kinase receptor-associated protein

3

3

Small-scale

0.640

High

787389

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

2

17

Small-scale

0.634

High

137993

PSDE
26S proteasome non-ATPase regulatory subunit 14

2

4

Small-scale

0.624

High

164271

NRP1
Neuropilin-1

2

3

Small-scale

0.624

High

343565

OXSR1
Serine/threonine-protein kinase OSR1

1

14

Small-scale

0.618

High

410673

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.618

High

463912

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

10

High-throughput

0.618

High

466132

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.618

High

601194

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

787355

TGFR1
TGF-beta receptor type-1

1

19

Small-scale

0.618

High

787359

NOTC1
Neurogenic locus notch homolog protein 1

1

2

Small-scale

0.618

High

787368

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

787370

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

787371

TGFB2
Transforming growth factor beta-2 proprotein

1

20

Small-scale

0.618

High

787372

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

787374

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

787380

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.618

High

787382

XIAP
E3 ubiquitin-protein ligase XIAP

1

7

Small-scale

0.618

High

787394

SQSTM
Sequestosome-1

1

4

Small-scale

0.618

High

787398

ARHG6
Rho guanine nucleotide exchange factor 6

1

5

Small-scale

0.618

High

787400

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

1

3

Small-scale

0.618

High

787402

MK14
Mitogen-activated protein kinase 14

1

4

Small-scale

0.618

High

787413

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.618

High

787436

OSTF1
Osteoclast-stimulating factor 1

1

10

High-throughput

0.618

High

787438

HAVR1
Hepatitis A virus cellular receptor 1

1

3

Small-scale

0.618

High

787444

PP16B
Protein phosphatase 1 regulatory inhibitor subunit 16B

1

4

Small-scale

0.618

High

787449

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

787452

PAR6A
Partitioning defective 6 homolog alpha

1

4

Small-scale

0.618

High

787456

RASF1
Ras association domain-containing protein 1

1

1

Small-scale

0.618

High

787367

EVA1C
Protein eva-1 homolog C

2

2

High-throughput

0.601

High

591239

CD44
CD44 antigen

2

2

Small-scale

0.595

High

787385

ACVR1
Activin receptor type-1

1

19

High-throughput

0.590

High

592923

ANK1
Ankyrin-1

1

0

Small-scale

0.586

High

787358

VHL
von Hippel-Lindau disease tumor suppressor

1

0

Small-scale

0.586

High

219845

SMAD6
Mothers against decapentaplegic homolog 6

2

20

Small-scale

0.584

High

699619

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

2

6

Small-scale

0.584

High

787384

CAV1
Caveolin-1

2

6

Small-scale

0.584

High

787432

TGFA1
Transforming growth factor-beta receptor-associated protein 1

2

3

Small-scale

0.584

High

749311

TNFL8
Tumor necrosis factor ligand superfamily member 8

2

0

High-throughput

0.576

High

254854

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

7

High-throughput

0.575

High

787404

MICB
MHC class I polypeptide-related sequence B

1

7

High-throughput

0.575

High

787405

HFE
Hereditary hemochromatosis protein

1

3

High-throughput

0.575

High

533609

CLUS
Clusterin

1

1

Small-scale

0.573

High

787399

T22D1
TSC22 domain family protein 1

1

6

Small-scale

0.573

High

787443

RANB9
Ran-binding protein 9

1

1

Small-scale

0.573

High

288361

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

14

Small-scale

0.561

High

555349

SKI
Ski oncogene

1

1

Small-scale

0.561

High

787365

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

5

Small-scale

0.561

High

787377

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

4

Small-scale

0.561

High

787390

BAMBI
BMP and activin membrane-bound inhibitor homolog

1

5

Small-scale

0.561

High

787440

OTUB1
Ubiquitin thioesterase OTUB1

1

4

Small-scale

0.561

High

787362

FNTA
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

1

1

Small-scale

0.549

High

787454

TMM9B
Transmembrane protein 9B

2

4

High-throughput

0.549

High

540335

LAMP1
Lysosome-associated membrane glycoprotein 1

2

0

High-throughput

0.547

High

341290

ECEL1
Endothelin-converting enzyme-like 1

1

1

High-throughput

0.536

High

564904

ICAM2
Intercellular adhesion molecule 2

1

1

High-throughput

0.536

High

787381

DAB2
Disabled homolog 2

1

1

Small-scale

0.536

High

787388

KLRB1
Killer cell lectin-like receptor subfamily B member 1

1

5

High-throughput

0.536

High

787392

KLRD1
Natural killer cells antigen CD94

1

5

High-throughput

0.536

High

787407

CC50B
Cell cycle control protein 50B

1

3

High-throughput

0.536

High

787411

I20RB
Interleukin-20 receptor subunit beta

1

8

High-throughput

0.536

High

787435

CLC2B
C-type lectin domain family 2 member B

1

5

High-throughput

0.536

High

787467

CLC4A
C-type lectin domain family 4 member A

1

1

High-throughput

0.536

High

188827

TMPS2
Transmembrane protease serine 2

1

4

High-throughput

0.515

High

787376

1433Z
14-3-3 protein zeta/delta

1

5

Small-scale

0.515

High

787455

TMPS4
Transmembrane protease serine 4

1

4

High-throughput

0.515

High

787462

NLGN3
Neuroligin-3

1

2

High-throughput

0.515

High

460246

CD3E
T-cell surface glycoprotein CD3 epsilon chain

1

0

High-throughput

0.513

High

787445

GML
Glycosyl-phosphatidylinositol-anchored molecule-like protein

1

0

High-throughput

0.513

High

787472

GOT1B
Vesicle transport protein GOT1B

1

0

High-throughput

0.513

High

787476

ENTP2
Ectonucleoside triphosphate diphosphohydrolase 2

1

0

High-throughput

0.513

High

787465

MYT1L
Myelin transcription factor 1-like protein

1

0

Small-scale

0.480

High

136318

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

13

Small-scale

0.479

High

178202

NPC1
NPC intracellular cholesterol transporter 1

1

2

High-throughput

0.479

High

217904

TGON2
Trans-Golgi network integral membrane protein 2

1

2

High-throughput

0.479

High

276281

HMMR
Hyaluronan mediated motility receptor

1

2

Small-scale

0.479

High

473669

ITA5
Integrin alpha-5

1

4

Small-scale

0.479

High

555458

SKIL
Ski-like protein

1

1

Small-scale

0.479

High

761563

HSP74
Heat shock 70 kDa protein 4

1

1

Small-scale

0.479

High

774185

BASI
Basigin

1

1

High-throughput

0.479

High

787360

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

19

Small-scale

0.479

High

787364

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

17

Small-scale

0.479

High

787375

AP2B1
AP-2 complex subunit beta

1

7

Small-scale

0.479

High

787383

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

1

Small-scale

0.479

High

787387

EP300
Histone acetyltransferase p300

1

1

Small-scale

0.479

High

787393

SMAD4
Mothers against decapentaplegic homolog 4

1

20

Small-scale

0.479

High

787403

OCLN
Occludin

1

2

Small-scale

0.479

High

787415

ZFY16
Zinc finger FYVE domain-containing protein 16

1

2

Small-scale

0.479

High

787416

KCNKI
Potassium channel subfamily K member 18

1

5

Small-scale

0.479

High

787417

TM11B
Transmembrane protease serine 11B

1

3

High-throughput

0.479

High

787418

PEG10
Retrotransposon-derived protein PEG10

1

8

Small-scale

0.479

High

787419

GOLI
E3 ubiquitin-protein ligase RNF130

1

12

High-throughput

0.479

High

787425

RN149
E3 ubiquitin-protein ligase RNF149

1

12

High-throughput

0.479

High

787429

DLG5
Disks large homolog 5

1

1

Small-scale

0.479

High

787431

UBP33
Ubiquitin carboxyl-terminal hydrolase 33

1

19

Small-scale

0.479

High

787437

SH3K1
SH3 domain-containing kinase-binding protein 1

1

6

Small-scale

0.479

High

787441

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

19

Small-scale

0.479

High

787442

SNX27
Sorting nexin-27

1

2

High-throughput

0.479

High

787447

TRAF4
TNF receptor-associated factor 4

1

5

Small-scale

0.479

High

787448

TOLIP
Toll-interacting protein

1

1

Small-scale

0.479

High

787457

DDX18
ATP-dependent RNA helicase DDX18

1

3

High-throughput

0.479

High

787466

CLC4E
C-type lectin domain family 4 member E

1

1

High-throughput

0.479

High

787468

SNX6
Sorting nexin-6

1

8

Small-scale

0.479

High

787471

RNF11
RING finger protein 11

1

14

Small-scale

0.479

High

787446

MYOC
Myocilin

1

0

Small-scale

0.460

High

293308

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

482844

TPM1
Tropomyosin alpha-1 chain

1

0

Small-scale

0.458

High

692876

DPP4
Dipeptidyl peptidase 4

1

0

High-throughput

0.458

High

776283

SOX11
Transcription factor SOX-11

1

0

Small-scale

0.458

High

787363

PSN1
Presenilin-1

1

0

Small-scale

0.458

High

787460

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

1

0

Small-scale

0.458

High

388381

B3AT
Band 3 anion transport protein

1

7

High-throughput

0.445

High

437634

HEPS
Serine protease hepsin

1

3

High-throughput

0.445

High

787361

PTH2R
Parathyroid hormone 2 receptor

1

1

High-throughput

0.445

High

787366

G6PT2
Glucose-6-phosphate exchanger SLC37A1

1

8

High-throughput

0.445

High

787397

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

3

High-throughput

0.445

High

787408

S39AC
Zinc transporter ZIP12

1

3

High-throughput

0.445

High

787409

NTCP5
Sodium/bile acid cotransporter 5

1

3

High-throughput

0.445

High

787412

S39A5
Zinc transporter ZIP5

1

3

High-throughput

0.445

High

787414

SV2B
Synaptic vesicle glycoprotein 2B

1

1

High-throughput

0.445

High

787421

CTL2
Choline transporter-like protein 2

1

6

High-throughput

0.445

High

787422

AGRG5
Adhesion G-protein coupled receptor G5

1

3

High-throughput

0.445

High

787424

CTL3
Choline transporter-like protein 3

1

6

High-throughput

0.445

High

787426

CTL5
Choline transporter-like protein 5

1

6

High-throughput

0.445

High

787433

CTL1
Choline transporter-like protein 1

1

6

High-throughput

0.445

High

787453

SO1B3
Solute carrier organic anion transporter family member 1B3

1

2

High-throughput

0.445

High

787459

SO1C1
Solute carrier organic anion transporter family member 1C1

1

2

High-throughput

0.445

High

787469

S22AE
Solute carrier family 22 member 14

1

1

High-throughput

0.445

High

787478

SO1B1
Solute carrier organic anion transporter family member 1B1

1

2

High-throughput

0.445

High

322909

UBP19
Ubiquitin carboxyl-terminal hydrolase 19

1

12

Small-scale

0.437

High

787458

FBX34
F-box only protein 34

1

1

Small-scale

0.437

High

222252

PSCA
Prostate stem cell antigen

1

0

High-throughput

0.426

High

787423

LYPD1
Ly6/PLAUR domain-containing protein 1

1

0

High-throughput

0.426

High

787428

GP156
Probable G-protein coupled receptor 156

1

0

High-throughput

0.426

High

787439

ASIC4
Acid-sensing ion channel 4

1

0

High-throughput

0.426

High

170685

CLGN
Calmegin

1

7

High-throughput

0.407

High

787410

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.407

High

787430

G6PT3
Glucose-6-phosphate exchanger SLC37A2

1

8

High-throughput

0.407

High

787463

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

4

High-throughput

0.407

High

787470

SL9A8
Sodium/hydrogen exchanger 8

1

1

High-throughput

0.407

High

547978

PSPC
Surfactant protein C

1

0

High-throughput

0.279

Low

787420

PLD3
5'-3' exonuclease PLD3

1

0

High-throughput

0.249

Low

787406

TMM95
Sperm-egg fusion protein TMEM95

1

0

High-throughput

0.232

Low

787434

PATE1
Prostate and testis expressed protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025