HitPredict

Interactor 1: MTOR (P42345)
Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin and FKBP12 target 1) (Rapamycin target protein 1)
Gene: MTOR

Interactor 2: PRR5L (Q6MZQ0)
Proline-rich protein 5-like (Protein observed with Rictor-2) (Protor-2)
Gene: PRR5L

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	0.60	0.660

Property	Details
Experiments	18030348, 17461779
Identification Methods	affinity chromatography technology, enzymatic study, anti tag coimmunoprecipitation, pull down, in-gel kinase assay
Interaction Type	physical association, direct interaction, phosphorylation reaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0031932 - TORC2 complex GO:0051897 - positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1 2549 Hs			1 368
+	Hs
		787457 MTOR_HUMAN (1-2549): 0: 2102: 100.00		PRR5_HUMAN (23-297): 5.21e-164: 465: 45.61
+	Mm
		1195029 MTOR_MOUSE (1-2549): 0: 2095: 98.94		PRR5_MOUSE (23-297): 3.82e-164: 466: 44.06