Protein: NUG1
Nuclear GTP-binding protein NUG1 (Nuclear GTPase 1)

Gene: NUG1
Organism: Saccharomyces cerevisiae S288C
Interactions: 214
UniProt ID: P40010

Gene Ontology (top 5):
GO:0000055 - ribosomal large subunit export from nucleus
GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0003723 - RNA binding
GO:0003729 - mRNA binding
GO:0003924 - GTPase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

816875

NOG2
Nucleolar GTP-binding protein 2

11

2

Small-scale

0.973

High

803868

CIC1
Proteasome-interacting protein CIC1

8

3

Small-scale

0.961

High

816872

PESC
Pescadillo homolog

13

2

Small-scale

0.757

High

816850

NOP2
25S rRNA

12

4

Small-scale

0.756

High

816893

ARX1
Probable metalloprotease ARX1

13

5

Small-scale

0.756

High

806613

RIX1
Pre-rRNA-processing protein RIX1

13

1

Small-scale

0.756

High

782342

RPF2
Ribosome biogenesis protein RPF2

11

3

Small-scale

0.755

High

816918

BUD20
Bud site selection protein 20

9

2

Small-scale

0.753

High

816889

NOG1
Nucleolar GTP-binding protein 1

11

9

Small-scale

0.753

High

816937

DBP10
ATP-dependent RNA helicase DBP10

9

11

Small-scale

0.751

High

816901

ERB1
Ribosome biogenesis protein ERB1

9

8

Small-scale

0.750

High

816873

SDA1
Protein SDA1

9

2

Small-scale

0.748

High

814326

NOC2
Nucleolar complex protein 2

9

1

Small-scale

0.748

High

816891

HAS1
ATP-dependent RNA helicase HAS1

9

19

Small-scale

0.745

High

673567

NLE1
Ribosome assembly protein 4

8

7

Small-scale

0.744

High

816916

NOC3
Nucleolar complex-associated protein 3

8

5

Small-scale

0.744

High

816880

NOP15
Ribosome biogenesis protein 15

7

8

High-throughput

0.744

High

816839

NSA2
Ribosome biogenesis protein NSA2

7

5

Small-scale

0.742

High

816928

MDN1
Midasin

7

5

Small-scale

0.740

High

816869

LSG1
Large subunit GTPase 1

2

2

Small-scale

0.737

High

791061

NOP4
Nucleolar protein 4

6

3

Small-scale

0.731

High

677205

SPB1
27S pre-rRNA

6

7

Small-scale

0.728

High

570031

RL3
Large ribosomal subunit protein uL3

6

3

Small-scale

0.726

High

682290

SPB4
ATP-dependent rRNA helicase SPB4

6

18

High-throughput

0.726

High

684740

RL5
Large ribosomal subunit protein uL18

6

5

Small-scale

0.726

High

816848

RLP7
Ribosome biogenesis protein RLP7

6

10

Small-scale

0.721

High

816930

NOP53
Ribosome biogenesis protein NOP53

6

4

Small-scale

0.721

High

816852

LOC1
60S ribosomal subunit assembly/export protein LOC1

5

1

Small-scale

0.711

High

816899

PUF6
Pumilio homology domain family member 6

5

2

Small-scale

0.706

High

780269

EBP2
rRNA-processing protein EBP2

5

3

High-throughput

0.704

High

750086

MRT4
Ribosome assembly factor MRT4

5

6

Small-scale

0.702

High

816868

NSA1
Ribosome biogenesis protein NSA1

5

2

Small-scale

0.702

High

816878

IPI3
Pre-rRNA-processing protein IPI3

5

10

Small-scale

0.702

High

816855

ALB1
Ribosome biogenesis protein ALB1

4

2

Small-scale

0.686

High

816929

YTM1
Ribosome biogenesis protein YTM1

4

11

High-throughput

0.686

High

816938

IF6
Eukaryotic translation initiation factor 6

4

5

Small-scale

0.686

High

816871

CGR1
rRNA-processing protein CGR1

4

2

Small-scale

0.685

High

804615

SSF1
Ribosome biogenesis protein SSF1

4

3

Small-scale

0.676

High

816895

RRP17
Ribosomal RNA-processing protein 17

4

1

High-throughput

0.676

High

816917

RLP24
Ribosome biogenesis protein RLP24

4

5

Small-scale

0.676

High

410157

RL25
Large ribosomal subunit protein uL23

3

3

Small-scale

0.656

High

816906

FKBP4
FK506-binding protein 4

3

2

High-throughput

0.656

High

816926

NIP7
60S ribosome subunit biogenesis protein NIP7

3

1

Small-scale

0.656

High

513691

RL2A
Large ribosomal subunit protein uL2A

3

6

High-throughput

0.640

High

792069

GBLP
Small ribosomal subunit protein RACK1

3

15

Small-scale

0.640

High

816838

IMB4
Importin subunit beta-4

3

6

Small-scale

0.633

High

435121

RS3
Small ribosomal subunit protein uS3

1

4

High-throughput

0.618

High

816769

NOP16
Nucleolar protein 16

3

0

High-throughput

0.613

High

805050

RPF1
Ribosome production factor 1

2

2

High-throughput

0.611

High

816879

NOP13
Nucleolar protein 13

2

3

High-throughput

0.611

High

816920

BRX1
Ribosome biogenesis protein BRX1

2

13

High-throughput

0.611

High

816927

TMA46
Translation machinery-associated protein 46

1

0

High-throughput

0.586

High

427295

RLA0
Large ribosomal subunit protein uL10

3

6

Small-scale

0.585

High

531755

RL4A
Large ribosomal subunit protein uL4A

2

9

Small-scale

0.584

High

689045

RL16A
Large ribosomal subunit protein uL13A

2

6

High-throughput

0.584

High

806130

NMD3
60S ribosomal export protein NMD3

2

1

Small-scale

0.584

High

816847

DSN1
Kinetochore-associated protein DSN1

2

1

High-throughput

0.584

High

816851

UTP10
U3 small nucleolar RNA-associated protein 10

2

2

High-throughput

0.584

High

816924

RS10A
Small ribosomal subunit protein eS10A

2

3

High-throughput

0.584

High

394595

EF1A
Elongation factor 1-alpha

1

3

High-throughput

0.575

High

689481

RS7A
Small ribosomal subunit protein eS7A

2

2

High-throughput

0.571

High

514293

RL12B
Large ribosomal subunit protein uL11B

1

1

High-throughput

0.553

High

725723

RM09
Large ribosomal subunit protein uL3m

2

6

High-throughput

0.537

High

783980

RM10
Large ribosomal subunit protein uL15m

2

2

High-throughput

0.537

High

503391

RL11A
Large ribosomal subunit protein uL5A

1

7

High-throughput

0.536

High

569793

RL30
Large ribosomal subunit protein eL30

1

3

High-throughput

0.536

High

585945

CSK21
Casein kinase II subunit alpha

1

5

High-throughput

0.536

High

656971

BUR1
Serine/threonine-protein kinase BUR1

1

1

High-throughput

0.536

High

709387

HRR25
Casein kinase I homolog HRR25

1

1

High-throughput

0.536

High

712581

RL8B
Large ribosomal subunit protein eL8B

1

6

High-throughput

0.536

High

721968

XPO1
Exportin-1

1

5

High-throughput

0.536

High

743217

PP12
Serine/threonine-protein phosphatase PP1-2

1

2

High-throughput

0.536

High

816863

RL4B
Large ribosomal subunit protein uL4B

1

9

High-throughput

0.536

High

816867

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

1

5

High-throughput

0.536

High

816874

BRE5
UBP3-associated protein BRE5

1

5

High-throughput

0.536

High

816885

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

2

High-throughput

0.536

High

816935

RL7B
Large ribosomal subunit protein uL30B

1

10

High-throughput

0.536

High

816888

SKI8
Antiviral protein SKI8

1

11

High-throughput

0.515

High

816859

YMR1
Phosphoinositide 3-phosphatase

1

0

High-throughput

0.513

High

816896

MUS81
Crossover junction endonuclease MUS81

1

0

High-throughput

0.513

High

816913

TSR1
Ribosome biogenesis protein TSR1

1

0

High-throughput

0.513

High

816915

NOP6
Nucleolar protein 6

1

0

High-throughput

0.513

High

518033

SSBP1
Single-stranded nucleic acid-binding protein

1

2

High-throughput

0.501

High

792816

ANM1
Protein arginine N-methyltransferase 1

1

1

Small-scale

0.501

High

704607

SBA1
Co-chaperone protein SBA1

1

0

High-throughput

0.493

High

816865

ROM2
RHO1 GDP-GTP exchange protein 2

1

0

High-throughput

0.493

High

453616

PYR1
Multifunctional protein URA2

1

1

High-throughput

0.489

High

816862

RL38
Large ribosomal subunit protein eL38

1

2

High-throughput

0.489

High

149787

RS9A
Small ribosomal subunit protein uS4A

1

3

High-throughput

0.479

High

392787

HSP82
ATP-dependent molecular chaperone HSP82

1

5

High-throughput

0.479

High

403522

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

1

Small-scale

0.479

High

419746

H2A2
Histone H2A.2

1

1

High-throughput

0.479

High

432595

RL7A
Large ribosomal subunit protein uL30A

1

10

High-throughput

0.479

High

433664

RL26A
Large ribosomal subunit protein uL24A

1

6

High-throughput

0.479

High

434581

RL22A
Large ribosomal subunit protein eL22A

1

5

High-throughput

0.479

High

435989

RS13
Small ribosomal subunit protein uS15

1

2

High-throughput

0.479

High

436427

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

1

High-throughput

0.479

High

438705

SC160
Protein SCP160

1

4

High-throughput

0.479

High

441930

RS14A
Small ribosomal subunit protein uS11A

1

1

High-throughput

0.479

High

455085

RS19A
Small ribosomal subunit protein eS19A

1

3

High-throughput

0.479

High

512462

RS6A
Small ribosomal subunit protein eS6A

1

5

High-throughput

0.479

High

514004

RL18B
Large ribosomal subunit protein eL18B

1

4

High-throughput

0.479

High

534113

MAK16
Protein MAK16

1

2

High-throughput

0.479

High

594386

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

1

High-throughput

0.479

High

601056

RL8A
Large ribosomal subunit protein eL8A

1

6

Small-scale

0.479

High

633166

MAK11
Protein MAK11

1

10

High-throughput

0.479

High

647120

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

2

High-throughput

0.479

High

670753

SIS1
Protein SIS1

1

2

High-throughput

0.479

High

674649

RS2
Small ribosomal subunit protein uS5

1

5

High-throughput

0.479

High

677412

KRR1
KRR1 small subunit processome component

1

2

High-throughput

0.479

High

707194

TF2B
Transcription initiation factor IIB

1

4

High-throughput

0.479

High

708741

TF3B
Transcription factor IIIB 70 kDa subunit

1

4

High-throughput

0.479

High

734997

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

1

High-throughput

0.479

High

745083

AFG2
ATPase family gene 2 protein

1

4

High-throughput

0.479

High

746630

DRS1
ATP-dependent RNA helicase DRS1

1

15

High-throughput

0.479

High

751407

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

1

High-throughput

0.479

High

758216

URB1
Nucleolar pre-ribosomal-associated protein 1

1

1

Small-scale

0.479

High

763077

RRP1
Ribosomal RNA-processing protein 1

1

4

High-throughput

0.479

High

778351

RS27A
Small ribosomal subunit protein eS27A

1

2

High-throughput

0.479

High

781200

RL14A
Large ribosomal subunit protein eL14A

1

4

High-throughput

0.479

High

795820

YBC8
UPF0642 protein YBL028C

1

1

High-throughput

0.479

High

798226

ENP1
Essential nuclear protein 1

1

1

High-throughput

0.479

High

802198

RS20
Small ribosomal subunit protein uS10

1

2

High-throughput

0.479

High

804987

IPI1
Pre-rRNA-processing protein IPI1

1

2

High-throughput

0.479

High

807078

FKBP3
Peptidyl-prolyl cis-trans isomerase

1

2

High-throughput

0.479

High

808826

UME6
Transcriptional regulatory protein UME6

1

1

High-throughput

0.479

High

812041

DHH1
ATP-dependent RNA helicase DHH1

1

7

High-throughput

0.479

High

812329

LAA1
AP-1 accessory protein LAA1

1

2

High-throughput

0.479

High

816844

BMT5
25S rRNA

1

1

High-throughput

0.479

High

816853

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

3

High-throughput

0.479

High

816856

MTR4
ATP-dependent RNA helicase DOB1

1

7

Small-scale

0.479

High

816858

MOG1
Nuclear import protein MOG1

1

1

High-throughput

0.479

High

816861

RL37A
Large ribosomal subunit protein eL37A

1

3

High-throughput

0.479

High

816864

UBC9
SUMO-conjugating enzyme UBC9

1

1

High-throughput

0.479

High

816876

JJJ1
J protein JJJ1

1

11

Small-scale

0.479

High

816877

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

4

High-throughput

0.479

High

816881

APJ1
J domain-containing protein APJ1

1

3

High-throughput

0.479

High

816882

RCM1
25S rRNA

1

4

High-throughput

0.479

High

816883

ORC1
Origin recognition complex subunit 1

1

2

High-throughput

0.479

High

816886

RS15
Small ribosomal subunit protein uS19

1

2

High-throughput

0.479

High

816890

TOM1
E3 ubiquitin-protein ligase TOM1

1

4

High-throughput

0.479

High

816894

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

1

High-throughput

0.479

High

816897

DHR1
Probable ATP-dependent RNA helicase DHR1

1

5

High-throughput

0.479

High

816898

RRB1
Ribosome assembly protein RRB1

1

8

High-throughput

0.479

High

816900

UTP14
U3 small nucleolar RNA-associated protein 14

1

3

High-throughput

0.479

High

816902

RRP5
rRNA biogenesis protein RRP5

1

3

High-throughput

0.479

High

816903

HRQ1
ATP-dependent helicase HRQ1

1

6

Small-scale

0.479

High

816904

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.479

High

816907

JIP5
WD repeat-containing protein JIP5

1

9

High-throughput

0.479

High

816908

TFC6
Transcription factor tau 91 kDa subunit

1

1

High-throughput

0.479

High

816910

NOC4
Nucleolar complex protein 4

1

9

High-throughput

0.479

High

816911

URN1
Pre-mRNA-splicing factor URN1

1

1

High-throughput

0.479

High

816919

NOP12
Nucleolar protein 12

1

7

High-throughput

0.479

High

816921

SGO1
Shugoshin

1

2

High-throughput

0.479

High

816922

TMA16
Translation machinery-associated protein 16

1

2

High-throughput

0.479

High

816925

RRS1
Regulator of ribosome biosynthesis

1

4

High-throughput

0.479

High

816931

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

1

High-throughput

0.479

High

816932

RRP6
Exosome complex exonuclease RRP6

1

2

High-throughput

0.479

High

816933

MAK21
Ribosome biogenesis protein MAK21

1

9

High-throughput

0.479

High

816934

RIO1
Serine/threonine-protein kinase RIO1

1

2

High-throughput

0.479

High

649224

SAN1
Protein SAN1

1

0

Small-scale

0.458

High

665183

DPB2
DNA polymerase epsilon subunit B

1

0

High-throughput

0.458

High

672891

RRP43
Exosome complex component RRP43

1

0

High-throughput

0.458

High

737868

HOG1
Mitogen-activated protein kinase HOG1

1

0

High-throughput

0.458

High

747877

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

780680

RRP14
Ribosomal RNA-processing protein 14

1

0

High-throughput

0.458

High

815126

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

0

Small-scale

0.458

High

816846

ULP2
Ubiquitin-like-specific protease 2

1

0

High-throughput

0.458

High

816857

NOP9
Nucleolar protein 9

1

0

Small-scale

0.458

High

816905

PDP3
NuA3 HAT complex component PDP3

1

0

High-throughput

0.458

High

816909

RRP15
Ribosomal RNA-processing protein 15

1

0

High-throughput

0.458

High

816936

SIZ2
E3 SUMO-protein ligase SIZ2

1

0

High-throughput

0.458

High

524061

HSP71
Heat shock protein SSA1

1

6

High-throughput

0.445

High

526787

HSP72
Heat shock protein SSA2

1

6

High-throughput

0.445

High

545000

SSB1
Ribosome-associated molecular chaperone SSB1

1

9

High-throughput

0.445

High

741649

HSP7F
Heat shock protein homolog SSE1

1

8

High-throughput

0.445

High

795871

LSM2
LSM complex subunit LSM2

1

1

High-throughput

0.445

High

811452

XDJ1
DnaJ protein homolog XDJ1

1

3

High-throughput

0.445

High

816840

SSB2
Ribosome-associated molecular chaperone SSB2

1

9

High-throughput

0.445

High

816887

NU116
Nucleoporin NUP116/NSP116

1

1

Small-scale

0.445

High

816892

CLU
Clustered mitochondria protein 1

1

1

High-throughput

0.445

High

383722

RS17A
Small ribosomal subunit protein eS17A

1

3

High-throughput

0.437

High

503066

RS22A
Small ribosomal subunit protein uS8A

1

2

High-throughput

0.437

High

503797

RL27A
Large ribosomal subunit protein eL27A

1

3

High-throughput

0.437

High

504234

RL31A
Large ribosomal subunit protein eL31A

1

6

High-throughput

0.437

High

511429

RL43B
Large ribosomal subunit protein eL43B

1

4

High-throughput

0.437

High

513029

RS8A
Small ribosomal subunit protein eS8A

1

3

High-throughput

0.437

High

514657

RS18A
Small ribosomal subunit protein uS13A

1

2

High-throughput

0.437

High

579457

HSC82
ATP-dependent molecular chaperone HSC82

1

5

High-throughput

0.437

High

747389

RSSA1
Small ribosomal subunit protein uS2A

1

5

High-throughput

0.437

High

753393

RS3A1
Small ribosomal subunit protein eS1A

1

3

High-throughput

0.437

High

797744

AIM4
Altered inheritance of mitochondria protein 4

1

1

High-throughput

0.437

High

816842

MLP2
Protein MLP2

1

2

High-throughput

0.437

High

816843

TM108
Protein TMA108

1

1

High-throughput

0.437

High

816845

RL34B
Large ribosomal subunit protein eL34B

1

4

High-throughput

0.437

High

816860

RS12
Small ribosomal subunit protein eS12

1

2

High-throughput

0.437

High

816884

NUM1
Nuclear migration protein NUM1

1

3

High-throughput

0.437

High

816914

VAM6
Vacuolar morphogenesis protein 6

1

4

High-throughput

0.437

High

631932

SRP54
Signal recognition particle subunit SRP54

1

0

High-throughput

0.426

High

816912

MHR1
Large ribosomal subunit protein mL67

1

0

High-throughput

0.426

High

511338

RL43A
Large ribosomal subunit protein eL43A

1

4

High-throughput

0.407

High

570258

RS17B
Small ribosomal subunit protein eS17B

1

3

High-throughput

0.407

High

798053

CLPX
ATP-dependent clpX-like chaperone, mitochondrial

1

2

High-throughput

0.407

High

810949

TCPD
T-complex protein 1 subunit delta

1

1

High-throughput

0.407

High

816854

PFD1
Prefoldin subunit 1

1

1

High-throughput

0.407

High

816849

CIN1
Chromosome instability protein 1

1

0

High-throughput

0.279

Low

816866

NBP1
NAP1-binding protein

1

0

Small-scale

0.279

Low

816870

YGI1
Uncharacterized protein YGL081W

1

0

High-throughput

0.279

Low

816923

HRK1
Serine/threonine-protein kinase HRK1

1

0

High-throughput

0.279

Low

797291

YSW1
Spore-specific protein YSW1

1

0

High-throughput

0.269

Low

477565

MYO1
Myosin-1

1

0

Small-scale

0.249

Low

780756

PSG1
PMA1 stabilization in the Golgi protein 1 [Cleaved into: PSG1-N'; PSG1-C']

1

0

High-throughput

0.249

Low

801052

FKS1
1,3-beta-glucan synthase component FKS1

1

0

High-throughput

0.232

Low

816841

6P21
6-phosphofructo-2-kinase 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025