HitPredict

Interactor 1: PI4KA (P42356)
Phosphatidylinositol 4-kinase alpha (PI4-kinase alpha) (PI4K-alpha) (PtdIns-4-kinase alpha) (EC 2.7.1.67) (Phosphatidylinositol 4-Kinase III alpha)
Gene: PI4KA

Interactor 2: PAR2 (P55085)
Proteinase-activated receptor 2 (PAR-2) (Coagulation factor II receptor-like 1) (G-protein coupled receptor 11) (Thrombin receptor-like 1) [Cleaved into: Proteinase-activated receptor 2, alternate cleaved 1; Proteinase-activated receptor 2, alternate cleaved 2]
Gene: F2RL1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	33961781
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 2102 Hs			1 397
+	Hs
		1117762 Q4LE69_HUMAN (30-2102): 0: 2747: 100.00		P2RY8_HUMAN (61-395): 1.57e-77: 245: 34.62
+	Hs
		787661 PI4KA_HUMAN (30-2102): 0: 2745: 100.00		P2RY8_HUMAN (61-395): 1.57e-77: 245: 34.62
+	Hs
		876131 Q4LE69_HUMAN (30-2102): 0: 2747: 100.00		PAR2_HUMAN (1-374): 1.43e-74: 239: 100.00
+	Hs
		723045 Q4LE69_HUMAN (30-2102): 0: 2747: 100.00		OPRM_HUMAN (5-397): 1.72e-74: 238: 21.66
+	Hs
		723014 PI4KA_HUMAN (30-2102): 0: 2745: 100.00		OPRM_HUMAN (5-397): 1.72e-74: 238: 21.66
+	Hs
		723312 Q4LE69_HUMAN (30-2102): 0: 2747: 100.00		APJ_HUMAN (55-383): 7.14e-70: 226: 23.17
+	Hs
		723280 PI4KA_HUMAN (30-2102): 0: 2745: 100.00		APJ_HUMAN (55-383): 7.14e-70: 226: 23.17
+	Hs
		824703 Q4LE69_HUMAN (30-2102): 0: 2747: 100.00		NPY2R_HUMAN (61-361): 4.07e-68: 221: 16.56
+	Hs
		787633 PI4KA_HUMAN (30-2102): 0: 2745: 100.00		NPY2R_HUMAN (61-361): 4.07e-68: 221: 16.56
+	Hs
		126596 Q4LE69_HUMAN (30-2102): 0: 2747: 100.00		P2Y10_HUMAN (60-354): 7.94e-30: 119: 29.90
+	Hs
		126574 PI4KA_HUMAN (30-2102): 0: 2745: 100.00		P2Y10_HUMAN (60-354): 7.94e-30: 119: 29.90
+	Hs
		787363 PK3CB_HUMAN (1555-2099): 3.14e-140: 468: 20.98		CXCR4_HUMAN (73-370): 5.97e-81: 254: 22.62
+	Hs
		822537 PK3CG_HUMAN (1503-2100): 2.11e-134: 453: 19.49		CXCR4_HUMAN (73-370): 5.97e-81: 254: 22.62
+	Mm
		936867 PK3CG_MOUSE (1503-2100): 1.28e-132: 447: 19.81		CXCR4_MOUSE (73-370): 1.59e-80: 253: 22.40
+	Hs
		1030924 ATR_HUMAN (1573-2101): 8.52e-106: 381: 13.13		GPR17_HUMAN (57-367): 8.1e-79: 249: 29.02
+	Hs
		128855 P3C2A_HUMAN (1392-2101): 1.39e-153: 521: 17.98		P2RY6_HUMAN (76-352): 1.05e-25: 107: 30.07
+	Hs
		723038 ATR_HUMAN (1573-2101): 8.52e-106: 381: 13.13		OPRM_HUMAN (5-397): 1.72e-74: 238: 21.66
+	Hs
		126573 PK3CB_HUMAN (1555-2099): 3.14e-140: 468: 20.98		P2Y10_HUMAN (60-354): 7.94e-30: 119: 29.90
+	Hs
		787392 PK3CB_HUMAN (1555-2099): 3.14e-140: 468: 20.98		LPAR5_HUMAN (80-395): 1.57e-28: 116: 28.75