Protein: SPB3
Serpin B3 (Protein T4-A) (Squamous cell carcinoma antigen 1) (SCCA-1)

Gene: SPB3, SERPINB3
Organism: Homo sapiens
Interactions: 213
UniProt ID: P29508

Gene Ontology (top 5):
GO:0001618 - virus receptor activity
GO:0002020 - protease binding
GO:0004867 - serine-type endopeptidase inhibitor activity
GO:0004869 - cysteine-type endopeptidase inhibitor activity
GO:0005576 - extracellular region

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

713343

SPB4
Serpin B4

4

8

High-throughput

0.895

High

713416

FNDC5
Fibronectin type III domain-containing protein 5

1

6

High-throughput

0.691

High

713470

SCN3B
Sodium channel regulatory subunit beta-3

1

2

High-throughput

0.691

High

600536

ZSC20
Zinc finger and SCAN domain-containing protein 20

3

2

High-throughput

0.667

High

713380

GPR18
N-arachidonyl glycine receptor

3

11

High-throughput

0.667

High

713381

KI3S1
Killer cell immunoglobulin-like receptor 3DS1

3

6

High-throughput

0.667

High

713415

ASCC1
Activating signal cointegrator 1 complex subunit 1

3

1

High-throughput

0.667

High

713432

SUSD3
Sushi domain-containing protein 3

3

1

High-throughput

0.667

High

713485

SHLB1
Endophilin-B1

3

2

High-throughput

0.667

High

376977

ANF
Natriuretic peptides A

2

1

High-throughput

0.628

High

391572

FRIH
Ferritin heavy chain

2

4

High-throughput

0.628

High

713387

ZIC1
Zinc finger protein ZIC 1

2

7

High-throughput

0.628

High

713431

RM38
Large ribosomal subunit protein mL38

2

2

High-throughput

0.628

High

713434

CDK15
Cyclin-dependent kinase 15

2

7

High-throughput

0.628

High

713444

RBM24
RNA-binding protein 24

2

3

High-throughput

0.628

High

713454

ACAD9
Complex I assembly factor ACAD9, mitochondrial

2

3

High-throughput

0.628

High

713455

DDX31
ATP-dependent DNA helicase DDX31

2

4

High-throughput

0.628

High

459226

CATL1
Procathepsin L

2

2

Small-scale

0.619

High

456197

CATD
Cathepsin D

1

1

High-throughput

0.618

High

671756

ZA2G
Zinc-alpha-2-glycoprotein

1

2

High-throughput

0.618

High

713337

SPB5
Serpin B5

1

8

High-throughput

0.618

High

713338

CEAM6
Cell adhesion molecule CEACAM6

1

1

High-throughput

0.618

High

713400

TRI67
Tripartite motif-containing protein 67

1

12

High-throughput

0.618

High

713475

PD1L1
Programmed cell death 1 ligand 1

1

1

High-throughput

0.618

High

713394

MYOME
Myomegalin

2

5

High-throughput

0.611

High

713482

DD19B
ATP-dependent RNA helicase DDX19B

2

9

High-throughput

0.611

High

713441

PHAF1
Phagosome assembly factor 1

3

2

High-throughput

0.609

High

371251

MYC
Myc proto-oncogene protein

2

6

High-throughput

0.584

High

713340

MK08
Mitogen-activated protein kinase 8

1

3

Small-scale

0.578

High

713350

UCP2
Dicarboxylate carrier SLC25A8

2

9

High-throughput

0.574

High

713466

TB22B
TBC1 domain family member 22B

2

7

High-throughput

0.574

High

713421

ARH40
Rho guanine nucleotide exchange factor 40

2

1

High-throughput

0.571

High

66483

RASFA
Ras association domain-containing protein 10

1

2

High-throughput

0.536

High

132571

UPK1A
Uroplakin-1a

1

6

High-throughput

0.536

High

135780

RTCA
RNA 3'-terminal phosphate cyclase

1

2

High-throughput

0.536

High

185164

FANCG
Fanconi anemia group G protein

1

1

High-throughput

0.536

High

222355

TSN6
Tetraspanin-6

1

3

High-throughput

0.536

High

227161

DYRK3
Dual specificity tyrosine-phosphorylation-regulated kinase 3

1

4

High-throughput

0.536

High

231109

AIRE
Autoimmune regulator

1

8

High-throughput

0.536

High

251712

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

1

4

High-throughput

0.536

High

254829

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

5

High-throughput

0.536

High

288069

FOXH1
Forkhead box protein H1

1

4

High-throughput

0.536

High

292562

RENR
Renin receptor

1

5

High-throughput

0.536

High

296874

RASF9
Ras association domain-containing protein 9

1

3

High-throughput

0.536

High

327174

ZFPL1
Zinc finger protein-like 1

1

1

High-throughput

0.536

High

348376

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

2

High-throughput

0.536

High

351662

SG1D1
Secretoglobin family 1D member 1

1

4

High-throughput

0.536

High

352687

NUDT3
Diphosphoinositol polyphosphate phosphohydrolase 1

1

4

High-throughput

0.536

High

477329

NMB
Neuromedin-B [Cleaved into: Neuromedin-B-32; Neuromedin-B]

1

1

High-throughput

0.536

High

540986

PIM1
Serine/threonine-protein kinase pim-1

1

3

High-throughput

0.536

High

552137

ADT3
ADP/ATP translocase 3

1

7

High-throughput

0.536

High

555342

SKI
Ski oncogene

1

2

High-throughput

0.536

High

563257

CFTR
Cystic fibrosis transmembrane conductance regulator

1

6

High-throughput

0.536

High

602740

AATC
Aspartate aminotransferase, cytoplasmic

1

8

High-throughput

0.536

High

622764

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

1

6

High-throughput

0.536

High

666799

CCNC
Cyclin-C

1

5

High-throughput

0.536

High

713329

PDIA3
Protein disulfide-isomerase A3

1

2

High-throughput

0.536

High

713330

MIP
Lens fiber major intrinsic protein

1

1

High-throughput

0.536

High

713334

CCR1
C-C chemokine receptor type 1

1

7

High-throughput

0.536

High

713335

GRK4
G protein-coupled receptor kinase 4

1

2

High-throughput

0.536

High

713342

PCP4
Calmodulin regulator protein PCP4

1

3

High-throughput

0.536

High

713346

ASCL1
Achaete-scute homolog 1

1

4

High-throughput

0.536

High

713348

BMX
Cytoplasmic tyrosine-protein kinase BMX

1

3

High-throughput

0.536

High

713351

STX17
Syntaxin-17

1

9

High-throughput

0.536

High

713352

DSCR6
Protein ripply3

1

7

High-throughput

0.536

High

713353

CF298
Cilia- and flagella-associated protein 298

1

3

High-throughput

0.536

High

713357

RB11A
Ras-related protein Rab-11A

1

3

High-throughput

0.536

High

713360

SSBP2
Single-stranded DNA-binding protein 2

1

5

High-throughput

0.536

High

713361

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

9

High-throughput

0.536

High

713365

GCYA1
Guanylate cyclase soluble subunit alpha-1

1

3

High-throughput

0.536

High

713366

RASF7
Ras association domain-containing protein 7

1

3

High-throughput

0.536

High

713368

EF1A2
Elongation factor 1-alpha 2

1

3

High-throughput

0.536

High

713369

GABPA
GA-binding protein alpha chain

1

5

High-throughput

0.536

High

713370

FMOD
Fibromodulin

1

2

High-throughput

0.536

High

713372

ZN154
Zinc finger protein 154

1

1

High-throughput

0.536

High

713374

CUL2
Cullin-2

1

6

High-throughput

0.536

High

713375

ITA9
Integrin alpha-9

1

2

High-throughput

0.536

High

713385

STK11
Serine/threonine-protein kinase STK11

1

4

High-throughput

0.536

High

713388

ZYX
Zyxin

1

2

High-throughput

0.536

High

713389

PKN2
Serine/threonine-protein kinase N2

1

7

High-throughput

0.536

High

713391

LRC10
Leucine-rich repeat-containing protein 10

1

3

High-throughput

0.536

High

713398

JADE1
Protein Jade-1

1

1

High-throughput

0.536

High

713401

DPPA4
Developmental pluripotency-associated protein 4

1

1

High-throughput

0.536

High

713402

APTX
Aprataxin

1

3

High-throughput

0.536

High

713403

ZN550
Zinc finger protein 550

1

3

High-throughput

0.536

High

713404

NEK8
Serine/threonine-protein kinase Nek8

1

4

High-throughput

0.536

High

713410

AROS
Active regulator of SIRT1

1

1

High-throughput

0.536

High

713412

CDKL3
Cyclin-dependent kinase-like 3

1

3

High-throughput

0.536

High

713413

TEX14
Inactive serine/threonine-protein kinase TEX14

1

11

High-throughput

0.536

High

713417

ANKK1
Ankyrin repeat and protein kinase domain-containing protein 1

1

5

High-throughput

0.536

High

713418

O13C3
Olfactory receptor 13C3

1

4

High-throughput

0.536

High

713423

ITLN2
Intelectin-2

1

2

High-throughput

0.536

High

713426

CSN5
COP9 signalosome complex subunit 5

1

1

High-throughput

0.536

High

713428

PIGT
GPI-anchor transamidase component PIGT

1

4

High-throughput

0.536

High

713429

SIA7F
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

1

4

High-throughput

0.536

High

713436

FCRL5
Fc receptor-like protein 5

1

1

High-throughput

0.536

High

713439

TREX2
Three prime repair exonuclease 2

1

2

High-throughput

0.536

High

713442

MMTA2
Multiple myeloma tumor-associated protein 2

1

5

High-throughput

0.536

High

713443

FUND2
FUN14 domain-containing protein 2

1

2

High-throughput

0.536

High

713445

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

6

High-throughput

0.536

High

713446

SRRT
Serrate RNA effector molecule homolog

1

5

High-throughput

0.536

High

713452

FBX44
F-box only protein 44

1

5

High-throughput

0.536

High

713456

COE2
Transcription factor COE2

1

5

High-throughput

0.536

High

713458

CLK4
Dual specificity protein kinase CLK4

1

4

High-throughput

0.536

High

713459

HES4
Transcription factor HES-4

1

4

High-throughput

0.536

High

713460

SHCAF
SIN3-HDAC complex-associated factor

1

2

High-throughput

0.536

High

713464

MBNL1
Muscleblind-like protein 1

1

5

High-throughput

0.536

High

713467

KLH11
Kelch-like protein 11

1

6

High-throughput

0.536

High

713478

DKK2
Dickkopf-related protein 2

1

1

High-throughput

0.536

High

713480

SMBT1
Scm-like with four MBT domains protein 1

1

1

High-throughput

0.536

High

713481

PHF11
PHD finger protein 11

1

8

High-throughput

0.536

High

713484

SSUH2
Protein SSUH2 homolog

1

8

High-throughput

0.536

High

713487

RN115
E3 ubiquitin-protein ligase RNF115

1

6

High-throughput

0.536

High

713489

NPTN
Neuroplastin

1

1

High-throughput

0.536

High

713386

USF2
Upstream stimulatory factor 2

1

6

High-throughput

0.515

High

713448

TRI55
Tripartite motif-containing protein 55

1

12

High-throughput

0.515

High

713468

IRAK4
Interleukin-1 receptor-associated kinase 4

1

0

High-throughput

0.513

High

680669

CATS
Cathepsin S

1

2

Small-scale

0.501

High

713339

CATK
Cathepsin K

1

2

Small-scale

0.501

High

713356

CDC42
Cell division control protein 42 homolog

1

3

High-throughput

0.501

High

713488

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

2

Small-scale

0.501

High

51528

PL8L1
PLAC8-like protein 1

1

1

High-throughput

0.489

High

229217

G6PT1
Glucose-6-phosphate exchanger SLC37A4

1

4

High-throughput

0.489

High

325287

OR2A4
Olfactory receptor 2A4

1

13

High-throughput

0.489

High

335305

M3K6
Mitogen-activated protein kinase kinase kinase 6

1

3

High-throughput

0.489

High

713344

PTSS1
Phosphatidylserine synthase 1

1

2

High-throughput

0.489

High

713349

NDST2
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2

1

1

High-throughput

0.489

High

713390

CR021
UPF0711 protein C18orf21

1

6

High-throughput

0.489

High

713393

EMC4
ER membrane protein complex subunit 4

1

3

High-throughput

0.489

High

713395

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

5

High-throughput

0.489

High

713399

MRM1
rRNA methyltransferase 1, mitochondrial

1

1

High-throughput

0.489

High

713407

MOGT3
2-acylglycerol O-acyltransferase 3

1

6

High-throughput

0.489

High

713408

BPHL
Serine hydrolase BPHL

1

1

High-throughput

0.489

High

713409

COA5
Cytochrome c oxidase assembly factor 5

1

2

High-throughput

0.489

High

713411

CERS3
Ceramide synthase 3

1

2

High-throughput

0.489

High

713420

RHBL4
Rhomboid-related protein 4

1

4

High-throughput

0.489

High

713430

SARAF
Store-operated calcium entry-associated regulatory factor

1

7

High-throughput

0.489

High

713433

F227B
Protein FAM227B

1

3

High-throughput

0.489

High

713435

TEFM
Transcription elongation factor, mitochondrial

1

3

High-throughput

0.489

High

713438

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

6

High-throughput

0.489

High

713440

SH23A
SH2 domain-containing protein 3A

1

9

High-throughput

0.489

High

713450

S2532
Solute carrier family 25 member 32

1

10

High-throughput

0.489

High

713457

UD110
UDP-glucuronosyltransferase 1A10

1

3

High-throughput

0.489

High

713462

TSSP
Thymus-specific serine protease

1

4

High-throughput

0.489

High

713465

ST7
Suppressor of tumorigenicity 7 protein

1

1

High-throughput

0.489

High

713469

ST32B
Serine/threonine-protein kinase 32B

1

1

High-throughput

0.489

High

713472

RM39
Large ribosomal subunit protein mL39

1

1

High-throughput

0.489

High

713474

PK2L2
Polycystin-2-like protein 2

1

2

High-throughput

0.489

High

136835

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

1

High-throughput

0.479

High

293253

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.479

High

302389

RNF8
E3 ubiquitin-protein ligase RNF8

1

6

High-throughput

0.479

High

424141

S10A8
Protein S100-A8

1

7

High-throughput

0.479

High

444906

S10A9
Protein S100-A9

1

9

High-throughput

0.479

High

456623

ANXA2
Annexin A2

1

2

High-throughput

0.479

High

457838

INVO
Involucrin

1

1

High-throughput

0.479

High

536567

HSP7C
Heat shock cognate 71 kDa protein

1

6

High-throughput

0.479

High

590814

TIMP2
Metalloproteinase inhibitor 2

1

1

High-throughput

0.479

High

606282

CEBPB
CCAAT/enhancer-binding protein beta

1

5

High-throughput

0.479

High

623123

RO52
E3 ubiquitin-protein ligase TRIM21

1

6

High-throughput

0.479

High

630210

TNR1B
Tumor necrosis factor receptor superfamily member 1B

1

1

High-throughput

0.479

High

681263

PSA3
Proteasome subunit alpha type-3

1

1

Small-scale

0.479

High

713331

S10A7
Protein S100-A7

1

9

High-throughput

0.479

High

713332

CASPE
Caspase-14

1

8

High-throughput

0.479

High

713333

1433S
14-3-3 protein sigma

1

3

High-throughput

0.479

High

713341

LEG7
Galectin-7

1

5

High-throughput

0.479

High

713345

MCM2
DNA replication licensing factor MCM2

1

6

High-throughput

0.479

High

713358

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

3

High-throughput

0.479

High

713362

VIGLN
Vigilin

1

3

High-throughput

0.479

High

713363

HSF1
Heat shock factor protein 1

1

1

High-throughput

0.479

High

713364

EWS
RNA-binding protein EWS

1

3

High-throughput

0.479

High

713371

FOXO1
Forkhead box protein O1

1

3

High-throughput

0.479

High

713373

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.479

High

713376

PKP1
Plakophilin-1

1

6

High-throughput

0.479

High

713377

DX39B
Spliceosome RNA helicase DDX39B

1

2

High-throughput

0.479

High

713378

BLMH
Bleomycin hydrolase

1

2

High-throughput

0.479

High

713379

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

6

High-throughput

0.479

High

713382

TNIP1
TNFAIP3-interacting protein 1

1

3

High-throughput

0.479

High

713383

EEA1
Early endosome antigen 1

1

3

High-throughput

0.479

High

713405

ZN598
E3 ubiquitin-protein ligase ZNF598

1

1

High-throughput

0.479

High

713406

PAQR2
Adiponectin receptor protein 2

1

1

Small-scale

0.479

High

713419

LNX1
E3 ubiquitin-protein ligase LNX

1

1

Small-scale

0.479

High

713424

TOPB1
DNA topoisomerase 2-binding protein 1

1

2

High-throughput

0.479

High

713425

ESR2
Estrogen receptor beta

1

8

High-throughput

0.479

High

713427

KISSR
KiSS-1 receptor

1

8

Small-scale

0.479

High

713437

CIC
Protein capicua homolog

1

9

High-throughput

0.479

High

713447

FACD2
Fanconi anemia group D2 protein

1

11

High-throughput

0.479

High

713453

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.479

High

713461

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

1

High-throughput

0.479

High

713463

ANLN
Anillin

1

1

High-throughput

0.479

High

713473

WWOX
WW domain-containing oxidoreductase

1

2

High-throughput

0.479

High

713476

CALL5
Calmodulin-like protein 5

1

2

High-throughput

0.479

High

713479

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

713483

TRI33
E3 ubiquitin-protein ligase TRIM33

1

7

High-throughput

0.479

High

713490

SCC4
MAU2 chromatid cohesion factor homolog

1

1

High-throughput

0.479

High

713336

MERL
Merlin

1

0

High-throughput

0.458

High

713359

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

Small-scale

0.458

High

713367

CREM
cAMP-responsive element modulator

1

0

Small-scale

0.458

High

713384

ELAV1
ELAV-like protein 1

1

0

Small-scale

0.458

High

713477

MARH2
E3 ubiquitin-protein ligase MARCHF2

1

0

High-throughput

0.458

High

713486

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.458

High

713347

GPC3
Glypican-3

1

3

High-throughput

0.445

High

713354

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

6

High-throughput

0.445

High

713355

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

5

High-throughput

0.445

High

713396

RNLS
Renalase

1

1

Small-scale

0.445

High

713397

A16L1
Autophagy-related protein 16-1

1

9

High-throughput

0.445

High

713449

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

5

High-throughput

0.445

High

713414

SLX4
Structure-specific endonuclease subunit SLX4

1

6

High-throughput

0.437

High

713422

POF1B
Protein POF1B

1

1

High-throughput

0.437

High

713451

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

5

High-throughput

0.437

High

713471

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

1

High-throughput

0.437

High

87341

OSCRI
SCRIB overlapping open reading frame protein

1

1

High-throughput

0.407

High

713392

COQ5
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial

1

0

High-throughput

0.279

Low

505282

F153B
Protein FAM153B

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025