HitPredict

Interactor 1: EPS15 (P42566)
Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p)
Gene: EPS15

Interactor 2: ANK2 (Q01484)
Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin)
Gene: ANK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	unassigned3713
Identification Methods	phage display
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0006897 - endocytosis GO:0015031 - protein transport GO:0016324 - apical plasma membrane
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 896 Hs			1 3957
+	Hs
		965155 EHD1_HUMAN (17-102): 8.74e-16: 83.5: 33.72		ANK2_HUMAN (1-3957): 0: 1910: 100.00
+	Hs
		965166 EHD3_HUMAN (12-102): 5.49e-15: 80.8: 28.57		ANK2_HUMAN (1-3957): 0: 1910: 100.00
+	Hs
		965167 EHD2_HUMAN (19-102): 1.88e-12: 72.7: 27.38		ANK2_HUMAN (1-3957): 0: 1910: 100.00
+	Hs
		965151 EHD4_HUMAN (213-318): 5.77e-11: 68.2: 38.68		ANK2_HUMAN (1-3957): 0: 1910: 100.00
+	Mm
		1208059 EHD1_MOUSE (17-102): 8.82e-16: 83.5: 32.56		ANK2_MOUSE (1-3957): 0: 1769: 80.90
+	Mm
		1208057 EHD3_MOUSE (12-102): 2.83e-15: 82: 28.57		ANK2_MOUSE (1-3957): 0: 1769: 80.90
+	Mm
		1208055 EHD4_MOUSE (12-111): 1.22e-14: 79.6: 33.00		ANK2_MOUSE (1-3957): 0: 1769: 80.90
+	Mm
		1206516 EHD2_MOUSE (19-102): 1.73e-12: 73.1: 27.38		ANK2_MOUSE (1-3957): 0: 1769: 80.90
+	Hs
		257713 ITSN2_HUMAN (3-845): 2.31e-61: 229: 14.40		ANR17_HUMAN (27-327): 1.68e-19: 99.8: 30.33
+	Hs
		1331788 EHD1_HUMAN (17-102): 8.74e-16: 83.5: 33.72		ANFY1_HUMAN (2-203): 1.72e-30: 135: 16.74
+	Hs
		1349321 EHD3_HUMAN (12-102): 5.49e-15: 80.8: 28.57		ANFY1_HUMAN (2-203): 1.72e-30: 135: 16.74
+	Hs
		1021469 EP15R_HUMAN (417-891): 5.86e-14: 78.3: 11.98		ANK3_HUMAN (3120-3957): 1.41e-10: 70.3: 8.79