Protein: EIF3L
Eukaryotic translation initiation factor 3 subunit L (eIF3l) (Eukaryotic translation initiation factor 3 subunit 6-interacting protein) (Eukaryotic translation initiation factor 3 subunit E-interacting protein)

Gene: EIF3L
Organism: Homo sapiens
Interactions: 218
UniProt ID: Q9Y262

Gene Ontology (top 5):
GO:0001650 - fibrillar center
GO:0001732 - formation of cytoplasmic translation initiation complex
GO:0003723 - RNA binding
GO:0003743 - translation initiation factor activity
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1354227

EIF3K
Eukaryotic translation initiation factor 3 subunit K

12

2

Small-scale

0.984

High

888462

EIF3E
Eukaryotic translation initiation factor 3 subunit E

9

1

Small-scale

0.972

High

1184169

EIF3M
Eukaryotic translation initiation factor 3 subunit M

7

1

Small-scale

0.964

High

1049682

EIF3A
Eukaryotic translation initiation factor 3 subunit A

6

1

Small-scale

0.947

High

124963

EIF3F
Eukaryotic translation initiation factor 3 subunit F

6

5

Small-scale

0.944

High

1305035

EIF3C
Eukaryotic translation initiation factor 3 subunit C

4

2

Small-scale

0.899

High

78331

EIFCL
Eukaryotic translation initiation factor 3 subunit C-like protein

3

2

High-throughput

0.861

High

177115

EIF3H
Eukaryotic translation initiation factor 3 subunit H

8

5

Small-scale

0.748

High

176883

EIF3D
Eukaryotic translation initiation factor 3 subunit D

7

1

Small-scale

0.747

High

879369

EIF3B
Eukaryotic translation initiation factor 3 subunit B

5

2

Small-scale

0.720

High

275958

EIF3G
Eukaryotic translation initiation factor 3 subunit G

5

2

High-throughput

0.718

High

1032179

EIF3I
Eukaryotic translation initiation factor 3 subunit I

5

1

High-throughput

0.718

High

320065

HERC2
E3 ubiquitin-protein ligase HERC2

4

1

Small-scale

0.683

High

587069

CSK22
Casein kinase II subunit alpha'

3

2

High-throughput

0.667

High

1156425

ZN746
Zinc finger protein 746

4

0

High-throughput

0.661

High

122107

PSD12
26S proteasome non-ATPase regulatory subunit 12

1

0

High-throughput

0.656

High

1127732

PRC2B
Protein PRRC2B

2

1

High-throughput

0.628

High

1051932

IF4A2
Eukaryotic initiation factor 4A-II

3

0

High-throughput

0.622

High

934568

CSK21
Casein kinase II subunit alpha

2

2

High-throughput

0.611

High

1030560

G3BP1
Ras GTPase-activating protein-binding protein 1

2

1

High-throughput

0.611

High

229088

PRKN
E3 ubiquitin-protein ligase parkin

2

1

High-throughput

0.584

High

980029

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

2

3

Small-scale

0.584

High

1146973

A16L1
Autophagy-related protein 16-1

2

3

High-throughput

0.584

High

780343

CCNF
Cyclin-F

2

0

High-throughput

0.576

High

370742

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

592588

RAB5A
Ras-related protein Rab-5A

2

0

High-throughput

0.547

High

229986

NUAK1
NUAK family SNF1-like kinase 1

1

1

High-throughput

0.536

High

545919

ERF3A
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

1

1

High-throughput

0.536

High

718334

BMI1
Polycomb complex protein BMI-1

1

2

High-throughput

0.536

High

780809

IF2G
Eukaryotic translation initiation factor 2 subunit 3

1

2

High-throughput

0.536

High

921780

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

1

High-throughput

0.536

High

929727

RACK1
Small ribosomal subunit protein RACK1

1

1

High-throughput

0.536

High

943173

KC1G2
Casein kinase I isoform gamma-2

1

1

High-throughput

0.536

High

1041289

CUL1
Cullin-1

1

1

High-throughput

0.536

High

1296191

SCYL1
N-terminal kinase-like protein

1

1

High-throughput

0.536

High

1312096

RBM42
RNA-binding protein 42

1

2

High-throughput

0.536

High

1314182

RIOK2
Serine/threonine-protein kinase RIO2

1

1

High-throughput

0.536

High

1357438

G3BP2
Ras GTPase-activating protein-binding protein 2

1

1

High-throughput

0.536

High

497828

TAU
Microtubule-associated protein tau

2

0

High-throughput

0.528

High

158060

KLF11
Krueppel-like factor 11

1

2

High-throughput

0.515

High

213912

DYRK3
Dual specificity tyrosine-phosphorylation-regulated kinase 3

1

0

High-throughput

0.513

High

255208

ATG13
Autophagy-related protein 13

1

0

High-throughput

0.513

High

283631

SRP72
Signal recognition particle subunit SRP72

1

0

High-throughput

0.513

High

380349

HG2A
HLA class II histocompatibility antigen gamma chain

1

0

High-throughput

0.513

High

417047

IF4E
Eukaryotic translation initiation factor 4E

1

0

High-throughput

0.513

High

418804

NPM
Nucleophosmin

1

0

High-throughput

0.513

High

448018

SRP19
Signal recognition particle 19 kDa protein

1

0

High-throughput

0.513

High

529930

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.513

High

647989

MARK3
MAP/microtubule affinity-regulating kinase 3

1

0

High-throughput

0.513

High

649831

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.513

High

806227

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.513

High

813854

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.513

High

828947

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.513

High

831086

CTCF
Transcriptional repressor CTCF

1

0

High-throughput

0.513

High

841033

MAP2
Methionine aminopeptidase 2

1

0

High-throughput

0.513

High

850768

BMX
Cytoplasmic tyrosine-protein kinase BMX

1

0

High-throughput

0.513

High

873887

IF5
Eukaryotic translation initiation factor 5

1

0

High-throughput

0.513

High

890521

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.513

High

908220

RS16
Small ribosomal subunit protein uS9

1

0

High-throughput

0.513

High

992612

ACK1
Activated CDC42 kinase 1

1

0

High-throughput

0.513

High

1054027

CAPR1
Caprin-1

1

0

High-throughput

0.513

High

1062413

CND2
Condensin complex subunit 2

1

0

High-throughput

0.513

High

1086044

IF16
Gamma-interferon-inducible protein 16

1

0

High-throughput

0.513

High

1221911

DDX60
Probable ATP-dependent RNA helicase DDX60

1

0

High-throughput

0.513

High

1243446

PDZD8
PDZ domain-containing protein 8

1

0

High-throughput

0.513

High

1246674

COQ8A
Atypical kinase COQ8A, mitochondrial

1

0

High-throughput

0.513

High

1263587

PSPC1
Paraspeckle component 1

1

0

High-throughput

0.513

High

1296540

PHAR3
Phosphatase and actin regulator 3

1

0

High-throughput

0.513

High

1304441

DNJC2
DnaJ homolog subfamily C member 2

1

0

High-throughput

0.513

High

1334293

AGO3
Protein argonaute-3

1

0

High-throughput

0.513

High

1342574

ENY2
Transcription and mRNA export factor ENY2

1

0

High-throughput

0.513

High

1354262

KS6B2
Ribosomal protein S6 kinase beta-2

1

0

High-throughput

0.513

High

1355310

SRP68
Signal recognition particle subunit SRP68

1

0

High-throughput

0.513

High

1377030

DRG1
Developmentally-regulated GTP-binding protein 1

1

0

High-throughput

0.513

High

976531

ERCC6
DNA excision repair protein ERCC-6

1

2

High-throughput

0.501

High

317038

KLF8
Krueppel-like factor 8

1

2

High-throughput

0.500

High

239631

EIF1B
Eukaryotic translation initiation factor 1b

1

0

High-throughput

0.493

High

1193209

SLN11
Schlafen family member 11

1

0

Small-scale

0.493

High

1190478

TT21B
Tetratricopeptide repeat protein 21B

1

1

High-throughput

0.489

High

782065

RGS2
Regulator of G-protein signaling 2

1

0

High-throughput

0.486

High

1078699

SMAD2
Mothers against decapentaplegic homolog 2

1

0

High-throughput

0.486

High

1327554

XRN2
5'-3' exoribonuclease 2

1

0

High-throughput

0.486

High

349740

RASH
GTPase HRas

1

0

Small-scale

0.480

High

1348707

RRN3
RNA polymerase I-specific transcription initiation factor RRN3

1

0

Small-scale

0.480

High

276063

EIF3J
Eukaryotic translation initiation factor 3 subunit J

1

0

Small-scale

0.479

High

131111

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

3

High-throughput

0.479

High

149438

CTRO
Citron Rho-interacting kinase

1

1

High-throughput

0.479

High

163486

XPO1
Exportin-1

1

3

High-throughput

0.479

High

203421

IF4G3
Eukaryotic translation initiation factor 4 gamma 3

1

3

High-throughput

0.479

High

245109

BRD4
Bromodomain-containing protein 4

1

1

High-throughput

0.479

High

271222

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

2

Small-scale

0.479

High

282751

RNF8
E3 ubiquitin-protein ligase RNF8

1

2

High-throughput

0.479

High

326824

SNAI1
Zinc finger protein SNAI1

1

1

High-throughput

0.479

High

400133

ICAM1
Intercellular adhesion molecule 1

1

1

High-throughput

0.479

High

596839

CD11B
Cyclin-dependent kinase 11B

1

1

High-throughput

0.479

High

669082

PML
Protein PML

1

1

High-throughput

0.479

High

809037

YAP1
Transcriptional coactivator YAP1

1

1

High-throughput

0.479

High

850239

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

1

High-throughput

0.479

High

974704

MECOM
Histone-lysine N-methyltransferase MECOM

1

1

High-throughput

0.479

High

983944

KPCZ
Protein kinase C zeta type

1

1

High-throughput

0.479

High

1018755

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

1

High-throughput

0.479

High

1028039

ERCC8
DNA excision repair protein ERCC-8

1

1

Small-scale

0.479

High

1030034

TIF1B
Transcription intermediary factor 1-beta

1

1

High-throughput

0.479

High

1038237

4EBP1
Eukaryotic translation initiation factor 4E-binding protein 1

1

1

High-throughput

0.479

High

1043315

CUL4A
Cullin-4A

1

1

High-throughput

0.479

High

1058323

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

1

Small-scale

0.479

High

1059950

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

1

High-throughput

0.479

High

1064271

TNIP1
TNFAIP3-interacting protein 1

1

1

High-throughput

0.479

High

1080491

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.479

High

1116630

LARP7
La-related protein 7

1

1

High-throughput

0.479

High

1243569

CSK23
Casein kinase II subunit alpha 3

1

2

High-throughput

0.479

High

1269961

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

1270537

HDAC2
Histone deacetylase 2

1

1

High-throughput

0.479

High

1304187

RING2
E3 ubiquitin-protein ligase RING2

1

2

High-throughput

0.479

High

1310555

RIOK1
Serine/threonine-protein kinase RIO1

1

1

High-throughput

0.479

High

1315550

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

1

High-throughput

0.479

High

1335049

PRD16
Histone-lysine N-methyltransferase PRDM16

1

1

High-throughput

0.479

High

1354164

HDAC6
Histone deacetylase 6

1

2

High-throughput

0.479

High

1357199

FZR1
Fizzy-related protein homolog

1

2

High-throughput

0.479

High

1357349

UBQL1
Ubiquilin-1

1

1

High-throughput

0.479

High

1357897

HDAC5
Histone deacetylase 5

1

2

High-throughput

0.479

High

1377032

RBM8A
RNA-binding protein 8A

1

1

High-throughput

0.479

High

119569

LEG9
Galectin-9

1

0

High-throughput

0.458

High

125800

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

0

High-throughput

0.458

High

266453

TAD2A
Transcriptional adapter 2-alpha

1

0

High-throughput

0.458

High

295417

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

303541

HEXI1
Protein HEXIM1

1

0

High-throughput

0.458

High

314414

AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1

1

0

Small-scale

0.458

High

323326

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

348271

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

387764

P53
Cellular tumor antigen p53

1

0

Small-scale

0.458

High

488424

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

0

High-throughput

0.458

High

530767

ITA4
Integrin alpha-4

1

0

High-throughput

0.458

High

554085

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

555698

H2AX
Histone H2AX

1

0

Small-scale

0.458

High

618740

IF4B
Eukaryotic translation initiation factor 4B

1

0

Small-scale

0.458

High

640670

DDX6
Probable ATP-dependent RNA helicase DDX6

1

0

High-throughput

0.458

High

652638

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

685118

STIP1
Stress-induced-phosphoprotein 1

1

0

High-throughput

0.458

High

721811

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

749970

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.458

High

786197

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.458

High

818623

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

824547

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

832789

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

875447

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

887984

CD81
CD81 antigen

1

0

High-throughput

0.458

High

893199

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.458

High

896264

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

903614

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.458

High

909344

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

941591

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

970076

KIF23
Kinesin-like protein KIF23

1

0

High-throughput

0.458

High

999229

EP300
Histone acetyltransferase p300

1

0

High-throughput

0.458

High

1022240

NFX1
Transcriptional repressor NF-X1

1

0

High-throughput

0.458

High

1036214

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

1054678

RBM39
RNA-binding protein 39

1

0

High-throughput

0.458

High

1064852

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

1066894

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

1126702

EMC4
ER membrane protein complex subunit 4

1

0

High-throughput

0.458

High

1140862

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.458

High

1148877

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

1199716

ZN598
E3 ubiquitin-protein ligase ZNF598

1

0

High-throughput

0.458

High

1221848

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

1230943

CMTR1
Cap-specific mRNA

1

0

High-throughput

0.458

High

1242435

CA131
Uncharacterized protein C1orf131

1

0

High-throughput

0.458

High

1267272

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

1281801

IGSF8
Immunoglobulin superfamily member 8

1

0

High-throughput

0.458

High

1302790

RUFY1
RUN and FYVE domain-containing protein 1

1

0

High-throughput

0.458

High

1307060

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.458

High

1316826

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

1327612

TOLIP
Toll-interacting protein

1

0

High-throughput

0.458

High

1329114

VP33B
Vacuolar protein sorting-associated protein 33B

1

0

High-throughput

0.458

High

1329219

GAN
Gigaxonin

1

0

High-throughput

0.458

High

1335687

LFG4
Protein lifeguard 4

1

0

High-throughput

0.458

High

1336060

MET14
N6-adenosine-methyltransferase non-catalytic subunit

1

0

High-throughput

0.458

High

1343392

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

1343810

ANLN
Anillin

1

0

High-throughput

0.458

High

1344417

4ET
Eukaryotic translation initiation factor 4E transporter

1

0

High-throughput

0.458

High

1344541

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

0

High-throughput

0.458

High

1354899

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1357530

ANGE1
Protein angel homolog 1

1

0

High-throughput

0.458

High

1315407

KLF16
Krueppel-like factor 16

1

2

High-throughput

0.457

High

1130738

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.445

High

840870

DYN2
Dynamin-2

1

0

High-throughput

0.438

High

1295252

SPTCS
Spatacsin

1

0

Small-scale

0.438

High

1344849

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.438

High

1038251

4EBP2
Eukaryotic translation initiation factor 4E-binding protein 2

1

1

High-throughput

0.437

High

1331656

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

1357852

CD11A
Cyclin-dependent kinase 11A

1

1

High-throughput

0.437

High

402639

JUN
Transcription factor Jun

1

0

High-throughput

0.426

High

532653

TCTP
Translationally-controlled tumor protein

1

0

Small-scale

0.426

High

1039951

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.426

High

1124663

ODFP2
Outer dense fiber protein 2

1

0

High-throughput

0.426

High

1281586

ZKSC4
Zinc finger protein with KRAB and SCAN domains 4

1

0

High-throughput

0.426

High

1304801

ZBT18
Zinc finger and BTB domain-containing protein 18

1

0

High-throughput

0.426

High

1316314

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

0

High-throughput

0.426

High

1157468

PPR18
Phostensin

2

0

High-throughput

0.316

High

581892

VCAM1
Vascular cell adhesion protein 1

2

0

High-throughput

0.298

High

166635

DCLK1
Serine/threonine-protein kinase DCLK1

1

0

High-throughput

0.279

Low

595763

MAK
Serine/threonine-protein kinase MAK

1

0

High-throughput

0.279

Low

949079

HTRA4
Serine protease HTRA4

1

0

High-throughput

0.279

Low

1250847

VANG1
Vang-like protein 1

1

0

High-throughput

0.279

Low

1377031

EMC9
ER membrane protein complex subunit 9

1

0

High-throughput

0.279

Low

225083

ZNRD2
Protein ZNRD2

1

0

High-throughput

0.249

Low

351776

SOMA
Somatotropin

1

0

High-throughput

0.249

Low

363355

FINC
Fibronectin

1

0

High-throughput

0.249

Low

385741

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

1062218

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.249

Low

1116881

FBX43
F-box only protein 43

1

0

Small-scale

0.249

Low

1166078

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

1172315

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1189061

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

1231375

RHG24
Rho GTPase-activating protein 24

1

0

High-throughput

0.249

Low

1274611

TP4A1
Protein tyrosine phosphatase type IVA 1

1

0

High-throughput

0.249

Low

1333734

AKTIP
AKT-interacting protein

1

0

Small-scale

0.249

Low

1134795

LITD1
LINE-1 type transposase domain-containing protein 1

1

0

High-throughput

0.232

Low

1296698

C170L
Cep170-like protein

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024