Protein: SRBP2
Sterol regulatory element-binding protein 2 (SREBP-2) (Class D basic helix-loop-helix protein 2) (bHLHd2) (Sterol regulatory element-binding transcription factor 2) [Cleaved into: Processed sterol regulatory element-binding protein 2 (Transcription factor SREBF2)]

Gene: SRBP2, SREBF2
Organism: Homo sapiens
Interactions: 142
UniProt ID: Q12772

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000139 - Golgi membrane
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1085419

NFYC
Nuclear transcription factor Y subunit gamma

3

2

High-throughput

0.861

High

1085420

FHL2
Four and a half LIM domains protein 2

3

12

High-throughput

0.858

High

1085413

SRBP2
Sterol regulatory element-binding protein 2

2

16

Small-scale

0.778

High

159193

ABLM1
Actin-binding LIM protein 1

1

10

High-throughput

0.698

High

1085418

FHL3
Four and a half LIM domains protein 3

1

12

High-throughput

0.698

High

1085428

ZYX
Zyxin

1

9

High-throughput

0.698

High

1085439

ABLM2
Actin-binding LIM protein 2

1

12

High-throughput

0.698

High

627521

DPA1
HLA class II histocompatibility antigen, DP alpha 1 chain

4

3

High-throughput

0.694

High

1085455

CBP
CREB-binding protein

3

20

Small-scale

0.667

High

1036203

NRG1
Pro-neuregulin-1, membrane-bound isoform

3

2

High-throughput

0.667

High

1085313

SCAP
Sterol regulatory element-binding protein cleavage-activating protein

3

18

Small-scale

0.656

High

787865

SRBP1
Sterol regulatory element-binding protein 1

1

18

Small-scale

0.647

High

691720

MK03
Mitogen-activated protein kinase 3

2

8

Small-scale

0.639

High

703558

MK01
Mitogen-activated protein kinase 1

2

8

Small-scale

0.639

High

833927

HNF4A
Hepatocyte nuclear factor 4-alpha

2

20

Small-scale

0.639

High

1085467

CGRF1
Cell growth regulator with RING finger domain protein 1

3

0

High-throughput

0.638

High

464938

SP1
Transcription factor Sp1

2

15

Small-scale

0.636

High

749766

CADH5
Cadherin-5

2

8

High-throughput

0.628

High

1085453

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

2

1

High-throughput

0.628

High

993531

UBC9
SUMO-conjugating enzyme UBC9

2

7

Small-scale

0.614

High

1085440

S39A4
Zinc transporter ZIP4

3

3

High-throughput

0.609

High

1085432

S39AC
Zinc transporter ZIP12

3

3

High-throughput

0.604

High

192488

INSI1
Insulin-induced gene 1 protein

2

2

Small-scale

0.584

High

1057539

ACHD
Acetylcholine receptor subunit delta

2

2

High-throughput

0.574

High

1085429

S4A8
Electroneutral sodium bicarbonate exchanger 1

2

1

High-throughput

0.574

High

1085441

TMCO3
Transmembrane and coiled-coil domain-containing protein 3

2

1

High-throughput

0.574

High

1085448

I17RC
Interleukin-17 receptor C

2

1

High-throughput

0.574

High

137533

NR5A2
Nuclear receptor subfamily 5 group A member 2

1

18

Small-scale

0.561

High

617291

ATF6A
Cyclic AMP-dependent transcription factor ATF-6 alpha

1

15

Small-scale

0.561

High

1085469

ZNT2
Proton-coupled zinc antiporter SLC30A2

2

3

High-throughput

0.552

High

1085486

VSIG4
V-set and immunoglobulin domain-containing protein 4

2

4

High-throughput

0.549

High

297590

PIAS1
E3 SUMO-protein ligase PIAS1

1

13

High-throughput

0.541

High

297800

PIAS2
E3 SUMO-protein ligase PIAS2

1

13

High-throughput

0.541

High

534985

BIP
Endoplasmic reticulum chaperone BiP

1

6

High-throughput

0.541

High

593093

CREB1
Cyclic AMP-responsive element-binding protein 1

1

8

High-throughput

0.541

High

613007

EGR1
Early growth response protein 1

1

7

High-throughput

0.541

High

659675

NFYA
Nuclear transcription factor Y subunit alpha

1

1

High-throughput

0.541

High

882466

ARRB1
Beta-arrestin-1

1

1

High-throughput

0.541

High

927261

ATX1
Ataxin-1

1

6

High-throughput

0.541

High

933625

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

3

High-throughput

0.541

High

1028744

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

5

High-throughput

0.541

High

1085415

ULA1
NEDD8-activating enzyme E1 regulatory subunit

1

1

High-throughput

0.541

High

1085423

GOGB1
Golgin subfamily B member 1

1

7

High-throughput

0.541

High

1085444

ZDH17
Palmitoyltransferase ZDHHC17

1

6

High-throughput

0.541

High

1085456

ARHG1
Rho guanine nucleotide exchange factor 1

1

3

High-throughput

0.541

High

1085457

CSN5
COP9 signalosome complex subunit 5

1

6

High-throughput

0.541

High

1085466

TTC1
Tetratricopeptide repeat protein 1

1

3

High-throughput

0.541

High

1085483

ZMYM2
Zinc finger MYM-type protein 2

1

7

High-throughput

0.541

High

1085485

C8AP2
CASP8-associated protein 2

1

1

High-throughput

0.541

High

1085495

S4A4
Electrogenic sodium bicarbonate cotransporter 1

1

1

High-throughput

0.541

High

1085496

PIAS3
E3 SUMO-protein ligase PIAS3

1

13

High-throughput

0.541

High

260753

RAMP2
Receptor activity-modifying protein 2

1

1

High-throughput

0.536

High

595041

KCNA2
Potassium voltage-gated channel subfamily A member 2

1

2

High-throughput

0.536

High

1085417

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

12

High-throughput

0.536

High

1085422

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

1

High-throughput

0.536

High

1085433

TTMP
TPA-induced transmembrane protein

1

1

High-throughput

0.536

High

1085450

KCNG4
Voltage-gated potassium channel regulatory subunit KCNG4

1

4

High-throughput

0.536

High

1085474

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

1

High-throughput

0.536

High

1085490

TMED5
Transmembrane emp24 domain-containing protein 5

1

4

High-throughput

0.536

High

1085414

OS9
Protein OS-9

1

0

High-throughput

0.518

High

413718

P53
Cellular tumor antigen p53

1

11

Small-scale

0.515

High

1014487

SMAD3
Mothers against decapentaplegic homolog 3

1

8

Small-scale

0.515

High

407170

CD3D
T-cell surface glycoprotein CD3 delta chain

1

0

High-throughput

0.513

High

547318

CP19A
Aromatase

1

0

High-throughput

0.513

High

1085436

FAXC
Failed axon connections homolog

1

0

High-throughput

0.513

High

1085459

RN170
E3 ubiquitin-protein ligase RNF170

1

0

High-throughput

0.513

High

1085471

TMM59
Transmembrane protein 59

1

0

High-throughput

0.513

High

1085477

CP26B
Cytochrome P450 26B1

1

0

High-throughput

0.513

High

1085480

MARH4
E3 ubiquitin-protein ligase MARCHF4

1

0

High-throughput

0.513

High

170106

AURKA
Aurora kinase A

1

4

Small-scale

0.501

High

840045

CASP3
Caspase-3

1

1

Small-scale

0.501

High

1067232

EP300
Histone acetyltransferase p300

1

20

Small-scale

0.501

High

1085424

IMB1
Importin subunit beta-1

1

2

Small-scale

0.501

High

1085489

KLF13
Krueppel-like factor 13

1

20

Small-scale

0.501

High

287782

MED6
Mediator of RNA polymerase II transcription subunit 6

1

1

Small-scale

0.500

High

881510

CDK8
Cyclin-dependent kinase 8

1

15

Small-scale

0.500

High

1085426

MED1
Mediator of RNA polymerase II transcription subunit 1

1

12

Small-scale

0.500

High

1085462

MED15
Mediator of RNA polymerase II transcription subunit 15

1

20

Small-scale

0.500

High

592646

ITB4
Integrin beta-4

1

6

High-throughput

0.494

High

1085447

LZTR1
Leucine-zipper-like transcriptional regulator 1

1

7

High-throughput

0.494

High

182520

GP182
G-protein coupled receptor 182

1

5

High-throughput

0.489

High

575651

GPIX
Platelet glycoprotein IX

1

2

High-throughput

0.489

High

607922

ACHB2
Neuronal acetylcholine receptor subunit beta-2

1

2

High-throughput

0.489

High

1085434

LRAD1
Low-density lipoprotein receptor class A domain-containing protein 1

1

3

High-throughput

0.489

High

1085437

TM268
Transmembrane protein 268

1

1

High-throughput

0.489

High

1085446

M4A15
Membrane-spanning 4-domains subfamily A member 15

1

1

High-throughput

0.489

High

1085476

TMM9B
Transmembrane protein 9B

1

1

High-throughput

0.489

High

1085492

PCDB3
Protocadherin beta-3

1

2

High-throughput

0.489

High

1085493

PCDGL
Protocadherin gamma-C4

1

2

High-throughput

0.489

High

1085443

MCAF1
Activating transcription factor 7-interacting protein 1

1

16

High-throughput

0.481

High

188260

HDAC3
Histone deacetylase 3

1

10

Small-scale

0.479

High

212393

SPIT2
Kunitz-type protease inhibitor 2

1

5

High-throughput

0.479

High

254482

PLPL9
85/88 kDa calcium-independent phospholipase A2

1

4

Small-scale

0.479

High

321227

ERLN2
Erlin-2

1

5

Small-scale

0.479

High

643358

OSBP1
Oxysterol-binding protein 1

1

3

Small-scale

0.479

High

1085416

CUL3
Cullin-3

1

6

High-throughput

0.479

High

1085421

NPAT
Protein NPAT

1

2

Small-scale

0.479

High

1085442

LMBRL
Protein LMBR1L

1

1

High-throughput

0.479

High

1085451

RN139
E3 ubiquitin-protein ligase RNF139

1

1

Small-scale

0.479

High

1085460

NR1H4
Bile acid receptor

1

20

Small-scale

0.479

High

1085463

UBP28
Ubiquitin carboxyl-terminal hydrolase 28

1

11

Small-scale

0.479

High

1085465

PARK7
Parkinson disease protein 7

1

2

Small-scale

0.479

High

1085468

HINFP
Histone H4 transcription factor

1

2

Small-scale

0.479

High

1085472

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

2

High-throughput

0.479

High

1085475

SPRNG
SREBP regulating gene protein

1

1

Small-scale

0.479

High

1085478

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

1

Small-scale

0.479

High

1085479

VAPA
Vesicle-associated membrane protein-associated protein A

1

1

Small-scale

0.479

High

1085484

NPCL1
NPC1-like intracellular cholesterol transporter 1

1

3

Small-scale

0.479

High

1085491

TRRAP
Transformation/transcription domain-associated protein

1

10

Small-scale

0.479

High

880908

MTR1B
Melatonin receptor type 1B

1

3

High-throughput

0.464

High

901210

RAB7A
Ras-related protein Rab-7a

1

0

High-throughput

0.458

High

1042737

PTH1R
Parathyroid hormone/parathyroid hormone-related peptide receptor

1

0

High-throughput

0.458

High

75479

B3KQF8
cDNA FLJ90387 fis, clone NT2RP2005391, highly similar to Homo sapiens activating transcription factor 7 interacting protein

1

13

High-throughput

0.457

High

843514

HD
Huntingtin

1

4

High-throughput

0.457

High

1085427

RB11B
Ras-related protein Rab-11B

1

1

High-throughput

0.457

High

166292

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

1

3

High-throughput

0.445

High

956854

CXCR4
C-X-C chemokine receptor type 4

1

3

High-throughput

0.445

High

1085425

TMED2
Transmembrane emp24 domain-containing protein 2

1

4

High-throughput

0.445

High

1085445

ZNT8
Proton-coupled zinc antiporter SLC30A8

1

3

High-throughput

0.445

High

1085449

ZNT7
Zinc transporter 7

1

3

High-throughput

0.445

High

1085454

S39A7
Zinc transporter SLC39A7

1

3

High-throughput

0.445

High

1085464

SL9A7
Sodium/hydrogen exchanger 7

1

4

High-throughput

0.445

High

1085487

S27A6
Long-chain fatty acid transport protein 6

1

3

High-throughput

0.445

High

1085488

S27A5
Long-chain fatty acid transport protein 5

1

3

High-throughput

0.445

High

379508

IGHM
Immunoglobulin heavy constant mu

1

3

High-throughput

0.407

High

844762

EAA1
Excitatory amino acid transporter 1

1

1

High-throughput

0.407

High

877659

SL9A3
Sodium/hydrogen exchanger 3

1

4

High-throughput

0.407

High

1085430

SL9C1
Solute carrier family 9 member C1

1

4

High-throughput

0.407

High

1085435

SL9C2
Sodium/hydrogen exchanger 11

1

4

High-throughput

0.407

High

1085438

SL9A4
Sodium/hydrogen exchanger 4

1

4

High-throughput

0.407

High

1085461

S26A8
Testis anion transporter 1

1

2

High-throughput

0.407

High

1085494

PCDGH
Protocadherin gamma-B5

1

2

High-throughput

0.407

High

821711

CD79B
B-cell antigen receptor complex-associated protein beta chain

2

0

High-throughput

0.328

High

1085482

DKK3
Dickkopf-related protein 3

2

0

High-throughput

0.328

High

1012684

RT06
Small ribosomal subunit protein bS6m

1

0

High-throughput

0.282

High

1085431

NKAI1
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1

1

0

High-throughput

0.279

Low

1085452

CC107
Coiled-coil domain-containing protein 107

1

0

High-throughput

0.279

Low

1085458

I17RA
Interleukin-17 receptor A

1

0

High-throughput

0.279

Low

1085470

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

0

High-throughput

0.279

Low

1085473

TTYH1
Protein tweety homolog 1

1

0

High-throughput

0.279

Low

1085481

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025