HitPredict

Interactor 1: EPS15 (P42566)
Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p)
Gene: EPS15

Interactor 2: FCHO2 (Q0JRZ9)
F-BAR domain only protein 2
Gene: FCHO2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.699

Property	Details
Experiments	27237791, 21762413, 35271311, 19380743
Identification Methods	pull down, affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005905 - clathrin-coated pit GO:0048268 - clathrin coat assembly
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 896 Hs			1 810
+	Hs
		147146 EPS15_HUMAN (1-896): 5.15e-160: 493: 100.00		FCHO1_HUMAN (3-810): 0: 567: 43.59
+	Hs
		1001577 ITSN1_HUMAN (2-520): 3.13e-38: 157: 14.61		FCHO2_HUMAN (1-810): 0: 740: 100.00
+	Hs
		1001598 EP15R_HUMAN (417-891): 5.86e-14: 78.3: 11.98		FCHO2_HUMAN (1-810): 0: 740: 100.00
+	Hs
		147162 ITSN1_HUMAN (2-520): 3.13e-38: 157: 14.61		FCHO1_HUMAN (3-810): 0: 567: 43.59
+	Hs
		147194 EP15R_HUMAN (417-891): 5.86e-14: 78.3: 11.98		FCHO1_HUMAN (3-810): 0: 567: 43.59
+	Hs
		787963 EPS15_HUMAN (1-896): 5.15e-160: 493: 100.00		SGIP1_HUMAN (234-580): 7.21e-10: 64.7: 25.35
+	Mm
		788006 EPS15_MOUSE (1-896): 6.54e-132: 419: 88.54		SGIP1_MOUSE (234-579): 5.18e-09: 62: 25.14
+	Hs
		1203306 ITSN2_HUMAN (3-845): 2.31e-61: 229: 14.40		FCSD1_HUMAN (15-595): 8.11e-64: 228: 12.60
+	Hs
		1078897 ITSN1_HUMAN (2-520): 3.13e-38: 157: 14.61		FNBP1_HUMAN (11-593): 9.49e-86: 286: 15.91
+	Hs
		1078931 ITSN1_HUMAN (2-520): 3.13e-38: 157: 14.61		PACN3_HUMAN (3-405): 1.68e-70: 239: 14.45
+	Hs
		1315998 EHD3_HUMAN (12-102): 5.49e-15: 80.8: 28.57		PACN1_HUMAN (1-405): 9.99e-82: 270: 16.47
+	Hs
		1331792 EHD1_HUMAN (17-102): 8.74e-16: 83.5: 33.72		PACN2_HUMAN (7-405): 1.43e-71: 244: 14.72
+	Rn
		1145116 EHD1_RAT (17-102): 8.82e-16: 83.5: 32.56		PACN2_RAT (7-405): 9.58e-71: 242: 14.44
+	Sp
		195123 YHLA_SCHPO (347-868): 1.07e-13: 77.5: 11.11		SYP1_SCHPO (1-533): 1.55e-63: 230: 15.29
+	Sc
		635278 EDE1_YEAST (3-327): 3e-15: 82.9: 24.01		SYP1_YEAST (19-536): 3.53e-58: 215: 12.43
+	Hs
		1309721 ITSN2_HUMAN (3-845): 2.31e-61: 229: 14.40		SGIP1_HUMAN (234-580): 7.21e-10: 64.7: 25.35
+	Hs
		1078901 ITSN1_HUMAN (2-520): 3.13e-38: 157: 14.61		SGIP1_HUMAN (234-580): 7.21e-10: 64.7: 25.35
+	Sc
		755622 END3_YEAST (15-378): 4.53e-13: 73.6: 17.73		BZZ1_YEAST (25-225): 1.61e-13: 76.4: 14.66
+	Hs
		1309722 EP15R_HUMAN (417-891): 5.86e-14: 78.3: 11.98		SGIP1_HUMAN (234-580): 7.21e-10: 64.7: 25.35