Protein: MED23
Mediator of RNA polymerase II transcription subunit 23 (Activator-recruited cofactor 130 kDa component) (ARC130) (Cofactor required for Sp1 transcriptional activation subunit 3) (CRSP complex subunit 3) (Mediator complex subunit 23) (Protein sur-2 homolog) (hSur-2) (Transcriptional coactivator CRSP130) (Vitamin D3 receptor-interacting protein complex 130 kDa component) (DRIP130)

Gene: MED23
Organism: Homo sapiens
Interactions: 218
UniProt ID: Q9ULK4

Gene Ontology (top 5):
GO:0003713 - transcription coactivator activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005667 - transcription regulator complex
GO:0006355 - regulation of DNA-templated transcription

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1259295

MED25
Mediator of RNA polymerase II transcription subunit 25

5

1

Small-scale

0.922

High

1461616

MED16
Mediator of RNA polymerase II transcription subunit 16

4

1

Small-scale

0.900

High

1401577

MED15
Mediator of RNA polymerase II transcription subunit 15

4

4

Small-scale

0.886

High

282431

MED24
Mediator of RNA polymerase II transcription subunit 24

2

1

High-throughput

0.820

High

881625

CDK8
Cyclin-dependent kinase 8

15

3

Small-scale

0.762

High

49038

MED19
Mediator of RNA polymerase II transcription subunit 19

8

1

Small-scale

0.752

High

1151310

MED1
Mediator of RNA polymerase II transcription subunit 1

6

4

Small-scale

0.733

High

1416411

CDK19
Cyclin-dependent kinase 19

6

3

High-throughput

0.733

High

1413643

MED10
Mediator of RNA polymerase II transcription subunit 10

6

1

Small-scale

0.732

High

666931

CCNC
Cyclin-C

6

1

High-throughput

0.724

High

239633

MED14
Mediator of RNA polymerase II transcription subunit 14

5

3

Small-scale

0.720

High

1414153

MED18
Mediator of RNA polymerase II transcription subunit 18

5

1

High-throughput

0.718

High

1446547

MED4
Mediator of RNA polymerase II transcription subunit 4

5

1

Small-scale

0.716

High

1452327

SCN3B
Sodium channel regulatory subunit beta-3

3

0

High-throughput

0.715

High

1372213

MED12
Mediator of RNA polymerase II transcription subunit 12

5

6

Small-scale

0.712

High

1460085

MED13
Mediator of RNA polymerase II transcription subunit 13

5

3

Small-scale

0.711

High

1108416

MED21
Mediator of RNA polymerase II transcription subunit 21

6

0

High-throughput

0.704

High

219527

MED7
Mediator of RNA polymerase II transcription subunit 7

4

1

High-throughput

0.699

High

1451893

MED29
Mediator of RNA polymerase II transcription subunit 29

4

1

High-throughput

0.699

High

1450391

MED17
Mediator of RNA polymerase II transcription subunit 17

4

2

High-throughput

0.694

High

1461617

MED31
Mediator of RNA polymerase II transcription subunit 31

4

2

High-throughput

0.694

High

287828

MED6
Mediator of RNA polymerase II transcription subunit 6

4

1

Small-scale

0.691

High

1008570

ELF3
ETS-related transcription factor Elf-3

4

1

Small-scale

0.688

High

1436791

MED20
Mediator of RNA polymerase II transcription subunit 20

3

1

High-throughput

0.678

High

1134817

NR1I3
Nuclear receptor subfamily 1 group I member 3

3

5

High-throughput

0.667

High

1391345

MED8
Mediator of RNA polymerase II transcription subunit 8

3

1

High-throughput

0.667

High

787902

SRBP1
Sterol regulatory element-binding protein 1

3

1

Small-scale

0.664

High

1431406

MED28
Mediator of RNA polymerase II transcription subunit 28

4

0

High-throughput

0.664

High

1451139

MED9
Mediator of RNA polymerase II transcription subunit 9

4

0

Small-scale

0.661

High

397200

ESR1
Estrogen receptor

3

4

Small-scale

0.660

High

1241423

MED27
Mediator of RNA polymerase II transcription subunit 27

3

2

High-throughput

0.656

High

1259079

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

3

3

High-throughput

0.656

High

1393387

MED30
Mediator of RNA polymerase II transcription subunit 30

3

1

Small-scale

0.656

High

336041

MED26
Mediator of RNA polymerase II transcription subunit 26

3

0

High-throughput

0.646

High

1367569

ESR2
Estrogen receptor beta

3

4

Small-scale

0.641

High

260603

BRD4
Bromodomain-containing protein 4

3

3

Small-scale

0.640

High

1453732

MED11
Mediator of RNA polymerase II transcription subunit 11

2

1

High-throughput

0.628

High

1295683

MD12L
Mediator of RNA polymerase II transcription subunit 12-like protein

2

5

High-throughput

0.611

High

1411752

RIOK1
Serine/threonine-protein kinase RIO1

2

1

Small-scale

0.611

High

543550

VDR
Vitamin D3 receptor

2

2

Small-scale

0.595

High

1149721

MED22
Mediator of RNA polymerase II transcription subunit 22

2

0

High-throughput

0.585

High

607215

CEBPB
CCAAT/enhancer-binding protein beta

1

2

Small-scale

0.561

High

714515

PML
Protein PML

2

0

High-throughput

0.559

High

1067829

EP300
Histone acetyltransferase p300

1

2

High-throughput

0.554

High

1368529

CBP
CREB-binding protein

1

2

High-throughput

0.554

High

1403524

MINT
Msx2-interacting protein

1

1

High-throughput

0.554

High

247025

KDM1A
Lysine-specific histone demethylase 1A

1

1

High-throughput

0.536

High

295549

PSD10
26S proteasome non-ATPase regulatory subunit 10

1

1

High-throughput

0.536

High

654685

TCEA1
Transcription elongation factor A protein 1

1

1

High-throughput

0.536

High

856979

BAG6
Large proline-rich protein BAG6

1

1

High-throughput

0.536

High

941603

CTBP2
C-terminal-binding protein 2

1

1

High-throughput

0.536

High

964770

DCAF7
DDB1- and CUL4-associated factor 7

1

1

High-throughput

0.536

High

1055872

RING1
E3 ubiquitin-protein ligase RING1

1

1

High-throughput

0.536

High

1103440

CTBP1
C-terminal-binding protein 1

1

1

High-throughput

0.536

High

1116127

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

1

High-throughput

0.536

High

1161434

HIF1A
Hypoxia-inducible factor 1-alpha

1

2

Small-scale

0.536

High

1314727

SRRM1
Serine/arginine repetitive matrix protein 1

1

1

High-throughput

0.536

High

1329140

CPSF7
Cleavage and polyadenylation specificity factor subunit 7

1

1

High-throughput

0.536

High

1369801

RAD50
DNA repair protein RAD50

1

1

High-throughput

0.536

High

1390334

ZN503
Zinc finger protein 503

1

1

High-throughput

0.536

High

1403300

RBM15
RNA-binding protein 15

1

1

High-throughput

0.536

High

1435903

ZN703
Zinc finger protein 703

1

1

High-throughput

0.536

High

1461613

TNR6B
Trinucleotide repeat-containing gene 6B protein

1

2

High-throughput

0.536

High

1461618

DYR1B
Dual specificity tyrosine-phosphorylation-regulated kinase 1B

1

1

High-throughput

0.536

High

442832

RB
Retinoblastoma-associated protein

1

0

High-throughput

0.530

High

1054817

SUH
Recombining binding protein suppressor of hairless

1

0

High-throughput

0.530

High

1365823

ZN516
Zinc finger protein 516

1

0

High-throughput

0.530

High

252494

DIAP1
Protein diaphanous homolog 1

1

0

High-throughput

0.513

High

625700

CSK22
Casein kinase II subunit alpha'

1

0

High-throughput

0.513

High

766934

PHB1
Prohibitin 1

1

0

High-throughput

0.513

High

822171

PSB10
Proteasome subunit beta type-10

1

0

High-throughput

0.513

High

832832

BCL6
B-cell lymphoma 6 protein

1

0

Small-scale

0.513

High

852878

VDAC2
Non-selective voltage-gated ion channel VDAC2

1

0

High-throughput

0.513

High

857590

NOTC1
Neurogenic locus notch homolog protein 1

1

0

High-throughput

0.513

High

936015

ECHB
Trifunctional enzyme subunit beta, mitochondrial

1

0

High-throughput

0.513

High

956201

SRP54
Signal recognition particle subunit SRP54

1

0

High-throughput

0.513

High

974218

RUXG
Small nuclear ribonucleoprotein G

1

0

High-throughput

0.513

High

988231

TRA2B
Transformer-2 protein homolog beta

1

0

High-throughput

0.513

High

1023646

CYC
Cytochrome c

1

0

High-throughput

0.513

High

1066811

NCBP1
Nuclear cap-binding protein subunit 1

1

0

High-throughput

0.513

High

1106312

ROCK1
Rho-associated protein kinase 1

1

0

High-throughput

0.513

High

1136510

FL2D
Pre-mRNA-splicing regulator WTAP

1

0

High-throughput

0.513

High

1139697

SYK
Lysine--tRNA ligase

1

0

High-throughput

0.513

High

1217928

BRE1A
E3 ubiquitin-protein ligase BRE1A

1

0

High-throughput

0.513

High

1238143

HMBX1
Homeobox-containing protein 1

1

0

High-throughput

0.513

High

1243789

FXL19
F-box/LRR-repeat protein 19

1

0

High-throughput

0.513

High

1259568

TBA1A
Tubulin alpha-1A chain

1

0

High-throughput

0.513

High

1384048

EXOS8
Exosome complex component RRP43

1

0

High-throughput

0.513

High

1390070

PTCD3
Small ribosomal subunit protein mS39

1

0

High-throughput

0.513

High

1399788

RBM14
RNA-binding protein 14

1

0

High-throughput

0.513

High

1409680

CND3
Condensin complex subunit 3

1

0

High-throughput

0.513

High

1446150

ENY2
Transcription and mRNA export factor ENY2

1

0

High-throughput

0.513

High

1454848

HOP2
Homologous-pairing protein 2 homolog

1

0

High-throughput

0.513

High

1461129

RCOR1
REST corepressor 1

1

0

High-throughput

0.513

High

1461615

PDIP2
Polymerase delta-interacting protein 2

1

0

High-throughput

0.513

High

175259

SC16A
Protein transport protein Sec16A

1

1

High-throughput

0.489

High

182830

GP182
G-protein coupled receptor 182

1

1

High-throughput

0.489

High

1124571

MAP7
Ensconsin

1

2

High-throughput

0.489

High

1132070

LTBP1
Latent-transforming growth factor beta-binding protein 1

1

1

High-throughput

0.489

High

1045898

TF65
Transcription factor p65

1

0

Small-scale

0.480

High

1461620

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

0

Small-scale

0.480

High

143324

NFIB
Nuclear factor 1 B-type

1

3

High-throughput

0.479

High

171349

MYPT1
Protein phosphatase 1 regulatory subunit 12A

1

1

High-throughput

0.479

High

283568

TAD2A
Transcriptional adapter 2-alpha

1

2

High-throughput

0.479

High

323600

TRI37
E3 ubiquitin-protein ligase TRIM37

1

1

High-throughput

0.479

High

373470

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

474368

NFIC
Nuclear factor 1 C-type

1

5

High-throughput

0.479

High

487874

PARP1
Poly [ADP-ribose] polymerase 1

1

1

Small-scale

0.479

High

520444

ANDR
Androgen receptor

1

4

High-throughput

0.479

High

834089

HNF4A
Hepatocyte nuclear factor 4-alpha

1

4

Small-scale

0.479

High

862543

YAP1
Transcriptional coactivator YAP1

1

1

High-throughput

0.479

High

905282

MECP2
Methyl-CpG-binding protein 2

1

1

High-throughput

0.479

High

958736

CSN2
COP9 signalosome complex subunit 2

1

1

Small-scale

0.479

High

1005239

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.479

High

1048131

TLE3
Transducin-like enhancer protein 3

1

1

High-throughput

0.479

High

1088096

NFIA
Nuclear factor 1 A-type

1

3

High-throughput

0.479

High

1130607

NCOA6
Nuclear receptor coactivator 6

1

1

Small-scale

0.479

High

1133733

NFIX
Nuclear factor 1 X-type

1

3

High-throughput

0.479

High

1136617

PSMD6
26S proteasome non-ATPase regulatory subunit 6

1

1

High-throughput

0.479

High

1141356

BRD3
Bromodomain-containing protein 3

1

5

High-throughput

0.479

High

1145560

RBBP5
Retinoblastoma-binding protein 5

1

1

High-throughput

0.479

High

1148190

PUM3
Pumilio homolog 3

1

1

High-throughput

0.479

High

1150418

NCOA2
Nuclear receptor coactivator 2

1

2

High-throughput

0.479

High

1198123

EPC2
Enhancer of polycomb homolog 2

1

1

High-throughput

0.479

High

1212056

ZC3HD
Zinc finger CCCH domain-containing protein 13

1

3

High-throughput

0.479

High

1235692

NIPBL
Nipped-B-like protein

1

2

Small-scale

0.479

High

1257168

PAXI1
PAX-interacting protein 1

1

1

High-throughput

0.479

High

1323549

ZN687
Zinc finger protein 687

1

1

High-throughput

0.479

High

1336884

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

4

Small-scale

0.479

High

1365473

ZN592
Zinc finger protein 592

1

1

High-throughput

0.479

High

1369221

KAT2B
Histone acetyltransferase KAT2B

1

4

High-throughput

0.479

High

1396759

EP400
E1A-binding protein p400

1

1

High-throughput

0.479

High

1402534

NEB2
Neurabin-2

1

1

High-throughput

0.479

High

1407431

EPAS1
Endothelial PAS domain-containing protein 1

1

2

Small-scale

0.479

High

1431822

EPC1
Enhancer of polycomb homolog 1

1

1

High-throughput

0.479

High

340426

YETS4
YEATS domain-containing protein 4

1

0

High-throughput

0.458

High

414830

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

533978

IRF1
Interferon regulatory factor 1

1

0

Small-scale

0.458

High

564551

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.458

High

590015

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

667507

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

High-throughput

0.458

High

681239

PSA2
Proteasome subunit alpha type-2

1

0

High-throughput

0.458

High

696845

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

769493

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

906614

PSMD7
26S proteasome non-ATPase regulatory subunit 7

1

0

High-throughput

0.458

High

968480

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

0

High-throughput

0.458

High

1026586

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

1040936

MECOM
Histone-lysine N-methyltransferase MECOM

1

0

High-throughput

0.458

High

1151403

TRIP4
Activating signal cointegrator 1

1

0

High-throughput

0.458

High

1213483

DCA12
DDB1- and CUL4-associated factor 12

1

0

High-throughput

0.458

High

1276954

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1314481

SLX4
Structure-specific endonuclease subunit SLX4

1

0

High-throughput

0.458

High

1329937

SIR6
NAD-dependent protein deacylase sirtuin-6

1

0

High-throughput

0.458

High

1334235

SPC24
Kinetochore protein Spc24

1

0

High-throughput

0.458

High

1337591

SP20H
Transcription factor SPT20 homolog

1

0

High-throughput

0.458

High

1371330

KAT5
Histone acetyltransferase KAT5

1

0

High-throughput

0.458

High

1380247

FBXW7
F-box/WD repeat-containing protein 7

1

0

Small-scale

0.458

High

1394994

VCIP1
Deubiquitinating protein VCPIP1

1

0

High-throughput

0.458

High

1396325

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

0

Small-scale

0.458

High

1400099

QKI
KH domain-containing RNA-binding protein QKI

1

0

High-throughput

0.458

High

1400709

PP1RA
Serine/threonine-protein phosphatase 1 regulatory subunit 10

1

0

High-throughput

0.458

High

1434845

STN1
CST complex subunit STN1

1

0

High-throughput

0.458

High

1449159

MBIP1
MAP3K12-binding inhibitory protein 1

1

0

High-throughput

0.458

High

1450243

MRGBP
MRG/MORF4L-binding protein

1

0

High-throughput

0.458

High

1453043

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1461534

ZN608
Zinc finger protein 608

1

0

High-throughput

0.458

High

1461621

TAF6L
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L

1

0

High-throughput

0.458

High

1327620

WDTC1
WD and tetratricopeptide repeats protein 1

1

1

Small-scale

0.457

High

95765

E5RFK5
Cyclin-C

1

1

High-throughput

0.445

High

1369176

KAT2A
Histone acetyltransferase KAT2A

1

5

Small-scale

0.445

High

1461614

FOXJ3
Forkhead box protein J3

1

0

Small-scale

0.438

High

488144

IFIT2
Interferon-induced protein with tetratricopeptide repeats 2

1

1

Small-scale

0.437

High

1360843

ASB11
Ankyrin repeat and SOCS box protein 11

1

1

High-throughput

0.437

High

1461619

TRRAP
Transformation/transcription domain-associated protein

1

0

Small-scale

0.426

High

1348140

PUM2
Pumilio homolog 2

1

1

Small-scale

0.417

High

577515

ETS1
Protein C-ets-1

1

1

Small-scale

0.408

High

887322

CEBPA
CCAAT/enhancer-binding protein alpha

1

2

High-throughput

0.408

High

76445

B4DUB1
cyclin-dependent kinase

1

3

High-throughput

0.407

High

1227694

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.407

High

1437562

FBRS
Probable fibrosin-1

1

0

High-throughput

0.289

High

130282

PGRC1
Membrane-associated progesterone receptor component 1

1

0

High-throughput

0.279

Low

344827

AP2A1
AP-2 complex subunit alpha-1

1

0

High-throughput

0.279

Low

369933

CO3
Complement C3

1

0

High-throughput

0.279

Low

483660

CN37
2',3'-cyclic-nucleotide 3'-phosphodiesterase

1

0

High-throughput

0.279

Low

568187

PLSL
Plastin-2

1

0

High-throughput

0.279

Low

585828

PHKG2
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform

1

0

High-throughput

0.279

Low

818810

CAP2
Adenylyl cyclase-associated protein 2

1

0

High-throughput

0.279

Low

829591

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

0

High-throughput

0.279

Low

847745

SSRA
Translocon-associated protein subunit alpha

1

0

High-throughput

0.279

Low

951515

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.279

Low

1101705

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

0

High-throughput

0.279

Low

1162744

QPCT
Glutaminyl-peptide cyclotransferase

1

0

High-throughput

0.279

Low

1199850

AGK
Acylglycerol kinase, mitochondrial

1

0

High-throughput

0.279

Low

1272129

RSRC2
Arginine/serine-rich coiled-coil protein 2

1

0

High-throughput

0.279

Low

1347479

CEP76
Centrosomal protein of 76 kDa

1

0

High-throughput

0.279

Low

1372508

KPBB
Phosphorylase b kinase regulatory subunit beta

1

0

High-throughput

0.279

Low

1383793

TTC28
Tetratricopeptide repeat protein 28

1

0

High-throughput

0.279

Low

1398862

DOCK7
Dedicator of cytokinesis protein 7

1

0

High-throughput

0.279

Low

1453689

CRIPT
Cysteine-rich PDZ-binding protein

1

0

High-throughput

0.279

Low

1453723

HACD3
Very-long-chain

1

0

High-throughput

0.279

Low

1454284

VPS18
Vacuolar protein sorting-associated protein 18 homolog

1

0

High-throughput

0.279

Low

1458431

GBG12

1

0

High-throughput

0.279

Low

1460411

ATIF1
ATPase inhibitor, mitochondrial

1

0

High-throughput

0.279

Low

1461612

COR1C
Coronin-1C

1

0

High-throughput

0.279

Low

294521

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

346487

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.249

Low

352652

TCL1B
T-cell leukemia/lymphoma protein 1B

1

0

High-throughput

0.249

Low

412796

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

959291

ABCE1
ATP-binding cassette sub-family E member 1

1

0

High-throughput

0.249

Low

1159250

SGCA
Alpha-sarcoglycan

1

0

High-throughput

0.249

Low

1256065

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1293312

LSR
Lipolysis-stimulated lipoprotein receptor

1

0

High-throughput

0.249

Low

1294590

DZIP3
E3 ubiquitin-protein ligase DZIP3

1

0

Small-scale

0.249

Low

1332914

KDF1
Keratinocyte differentiation factor 1

1

0

High-throughput

0.249

Low

1434212

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

1461611

HECD1
E3 ubiquitin-protein ligase HECTD1

1

0

High-throughput

0.249

Low

380187

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.232

Low

1395426

NEUL4
Neuralized-like protein 4

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025