HitPredict

Interactor 1: AF9 (P42568)
Protein AF-9 (ALL1-fused gene from chromosome 9 protein) (Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein) (YEATS domain-containing protein 3)
Gene: MLLT3

Interactor 2: H31 (P68431)
Histone H3.1 (Histone H3/a) (Histone H3/b) (Histone H3/c) (Histone H3/d) (Histone H3/f) (Histone H3/h) (Histone H3/i) (Histone H3/j) (Histone H3/k) (Histone H3/l)
Gene: H3C1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.50	0.60	0.550

Property	Details
Experiments	30385749
Identification Methods	x-ray crystallography, pull down
Interaction Type	association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0010467 - gene expression GO:0070062 - extracellular exosome
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 568 Hs			1 136
+	Hs
		788024 AF9_HUMAN (1-568): 1.02e-96: 307: 100.00		H33_HUMAN (1-136): 2.73e-61: 186: 96.32
+	Hs
		934679 ENL_HUMAN (1-567): 1.44e-70: 238: 50.00		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Hs
		974484 ENL_HUMAN (1-567): 1.44e-70: 238: 50.00		H31T_HUMAN (1-136): 1.27e-61: 187: 97.06
+	Hs
		934881 NIPBL_HUMAN (139-558): 7.01e-62: 223: 16.94		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Hs
		952407 NIPBL_HUMAN (139-558): 7.01e-62: 223: 16.94		H33_HUMAN (1-136): 2.73e-61: 186: 96.32
+	Hs
		828200 ENL_HUMAN (1-567): 1.44e-70: 238: 50.00		CENPA_HUMAN (9-133): 5.62e-45: 145: 50.00
+	Hs
		828271 NIPBL_HUMAN (139-558): 7.01e-62: 223: 16.94		CENPA_HUMAN (9-133): 5.62e-45: 145: 50.00
+	Hs
		317431 YETS4_HUMAN (6-190): 1.98e-45: 161: 20.42		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Hs
		317445 YETS4_HUMAN (6-190): 1.98e-45: 161: 20.42		H31T_HUMAN (1-136): 1.27e-61: 187: 97.06
+	Sc
		866308 AF9_YEAST (5-202): 1.65e-45: 161: 21.62		H3_YEAST (1-136): 1.16e-55: 172: 88.97
+	Sc
		715719 TAF14_YEAST (6-186): 2.13e-31: 124: 20.97		H3_YEAST (1-136): 1.16e-55: 172: 88.97
+	Sc
		902171 SAS5_YEAST (6-104): 2.4e-27: 112: 20.00		H3_YEAST (1-136): 1.16e-55: 172: 88.97
+	Hs
		934668 ANK2_HUMAN (186-504): 6.94e-10: 64.4: 11.15		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Hs
		965127 ANK2_HUMAN (186-504): 6.94e-10: 64.4: 11.15		H32_HUMAN (1-136): 6.5e-61: 185: 99.27
+	Hs
		935049 TITIN_HUMAN (145-514): 7.97e-09: 61.2: 10.86		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Hs
		1174610 TITIN_HUMAN (145-514): 7.97e-09: 61.2: 10.86		H32_HUMAN (1-136): 6.5e-61: 185: 99.27