HitPredict

Interactor 1: AF9 (P42568)
Protein AF-9 (ALL1-fused gene from chromosome 9 protein) (Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein) (YEATS domain-containing protein 3)
Gene: MLLT3

Interactor 2: H33 (P84243)
Histone H3.3
Gene: H3-3A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	0.60	0.586

Property	Details
Experiments	25417107
Identification Methods	pull down, x-ray crystallography, affinity chromatography technology
Interaction Type	direct interaction, association, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0070062 - extracellular exosome
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 568 Hs			1 136
+	Hs
		788023 AF9_HUMAN (1-568): 1.02e-96: 307: 100.00		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		934679 ENL_HUMAN (1-567): 1.44e-70: 238: 50.00		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		974484 ENL_HUMAN (1-567): 1.44e-70: 238: 50.00		H31T_HUMAN (1-136): 2.58e-59: 181: 93.38
+	Hs
		934881 NIPBL_HUMAN (139-558): 7.01e-62: 223: 16.94		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		952407 NIPBL_HUMAN (139-558): 7.01e-62: 223: 16.94		H33_HUMAN (1-136): 1.12e-59: 182: 100.00
+	Hs
		828200 ENL_HUMAN (1-567): 1.44e-70: 238: 50.00		CENPA_HUMAN (9-133): 2.42e-45: 146: 50.76
+	Hs
		828271 NIPBL_HUMAN (139-558): 7.01e-62: 223: 16.94		CENPA_HUMAN (9-133): 2.42e-45: 146: 50.76
+	Hs
		317431 YETS4_HUMAN (6-190): 1.98e-45: 161: 20.42		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		317445 YETS4_HUMAN (6-190): 1.98e-45: 161: 20.42		H31T_HUMAN (1-136): 2.58e-59: 181: 93.38
+	Sc
		866308 AF9_YEAST (5-202): 1.65e-45: 161: 21.62		H3_YEAST (1-136): 3.62e-54: 168: 90.44
+	Sc
		715719 TAF14_YEAST (6-186): 2.13e-31: 124: 20.97		H3_YEAST (1-136): 3.62e-54: 168: 90.44
+	Sc
		902171 SAS5_YEAST (6-104): 2.4e-27: 112: 20.00		H3_YEAST (1-136): 3.62e-54: 168: 90.44
+	Hs
		934668 ANK2_HUMAN (186-504): 6.94e-10: 64.4: 11.15		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		965127 ANK2_HUMAN (186-504): 6.94e-10: 64.4: 11.15		H32_HUMAN (1-136): 5.32e-59: 180: 97.06
+	Hs
		935049 TITIN_HUMAN (145-514): 7.97e-09: 61.2: 10.86		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		1174610 TITIN_HUMAN (145-514): 7.97e-09: 61.2: 10.86		H32_HUMAN (1-136): 5.32e-59: 180: 97.06