Protein: ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (EC 2.3.1.12) (70 kDa mitochondrial autoantigen of primary biliary cirrhosis) (PBC) (Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex) (M2 antigen complex 70 kDa subunit) (Pyruvate dehydrogenase complex component E2) (PDC-E2) (PDCE2)

Gene: ODP2, DLAT
Organism: Homo sapiens
Interactions: 212
UniProt ID: P10515

Gene Ontology (top 5):
GO:0004742 - dihydrolipoyllysine-residue acetyltransferase activity
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0006006 - glucose metabolic process
GO:0006086 - pyruvate decarboxylation to acetyl-CoA

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

522365

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

5

8

Small-scale

0.929

High

484343

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

3

16

High-throughput

0.861

High

132814

ODPX
Pyruvate dehydrogenase protein X component, mitochondrial

2

15

Small-scale

0.767

High

522362

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

2

14

Small-scale

0.715

High

522429

PDK3
[Pyruvate dehydrogenase

4

9

Small-scale

0.698

High

522385

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

15

High-throughput

0.691

High

470819

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

14

High-throughput

0.618

High

522428

PDK2
[Pyruvate dehydrogenase

2

9

Small-scale

0.602

High

522427

PDK1
[Pyruvate dehydrogenase

2

9

Small-scale

0.595

High

371013

MYC
Myc proto-oncogene protein

3

3

Small-scale

0.585

High

279624

CISY
Citrate synthase, mitochondrial

2

3

High-throughput

0.584

High

522389

STA5A
Signal transducer and activator of transcription 5A

2

3

High-throughput

0.574

High

522414

FOXD4
Forkhead box protein D4

2

1

High-throughput

0.574

High

522468

ESR2
Estrogen receptor beta

2

7

High-throughput

0.571

High

522532

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

5

High-throughput

0.568

High

105187

APRIO
Alternative prion protein

2

1

High-throughput

0.533

High

522399

PPT1
Palmitoyl-protein thioesterase 1

2

1

Small-scale

0.533

High

522526

HECD1
E3 ubiquitin-protein ligase HECTD1

2

7

High-throughput

0.533

High

217751

TGON2
Trans-Golgi network integral membrane protein 2

2

2

High-throughput

0.521

High

522372

RAB5A
Ras-related protein Rab-5A

2

8

High-throughput

0.521

High

522378

CALX
Calnexin

2

1

High-throughput

0.521

High

522440

ARHGG
Rho guanine nucleotide exchange factor 16

2

1

High-throughput

0.521

High

522447

PKHG7
Pleckstrin homology domain-containing family G member 7

2

2

High-throughput

0.521

High

522521

RHG23
Rho GTPase-activating protein 23

2

3

High-throughput

0.521

High

317395

KPCD3
Serine/threonine-protein kinase D3

1

1

High-throughput

0.494

High

522402

HUNK
Hormonally up-regulated neu tumor-associated kinase

1

1

High-throughput

0.494

High

522369

MIF
Macrophage migration inhibitory factor

1

1

High-throughput

0.489

High

522380

CLIP1
CAP-Gly domain-containing linker protein 1

1

6

High-throughput

0.489

High

522393

KI67
Proliferation marker protein Ki-67

1

4

High-throughput

0.489

High

522396

CAPZB
F-actin-capping protein subunit beta

1

1

High-throughput

0.489

High

522401

STA5B
Signal transducer and activator of transcription 5B

1

3

High-throughput

0.489

High

522417

CUL1
Cullin-1

1

1

High-throughput

0.489

High

522449

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

1

3

High-throughput

0.489

High

522455

TLK2
Serine/threonine-protein kinase tousled-like 2

1

2

High-throughput

0.489

High

522469

CSN5
COP9 signalosome complex subunit 5

1

1

High-throughput

0.489

High

522480

SCN2A
Sodium channel protein type 2 subunit alpha

1

3

High-throughput

0.489

High

522490

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

3

High-throughput

0.489

High

522523

HDAC6
Protein deacetylase HDAC6

1

3

High-throughput

0.489

High

61408

VWA8
von Willebrand factor A domain-containing protein 8

1

2

High-throughput

0.479

High

66117

MET15
12S rRNA N(4)-cytidine methyltransferase METTL15

1

2

High-throughput

0.479

High

183579

RT12
Small ribosomal subunit protein uS12m

1

1

High-throughput

0.479

High

240571

PRKN
E3 ubiquitin-protein ligase parkin

1

7

High-throughput

0.479

High

257316

PAGE4
P antigen family member 4

1

1

High-throughput

0.479

High

281862

MPPB
Mitochondrial-processing peptidase subunit beta

1

10

High-throughput

0.479

High

287227

RF1M
Peptide chain release factor 1, mitochondrial

1

10

High-throughput

0.479

High

350771

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

5

High-throughput

0.479

High

361596

OTC
Ornithine transcarbamylase, mitochondrial

1

3

High-throughput

0.479

High

400182

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

403771

GCR
Glucocorticoid receptor

1

7

Small-scale

0.479

High

411244

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.479

High

519033

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

1

High-throughput

0.479

High

522363

CH60
60 kDa heat shock protein, mitochondrial

1

5

High-throughput

0.479

High

522364

BIP
Endoplasmic reticulum chaperone BiP

1

4

High-throughput

0.479

High

522366

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

2

High-throughput

0.479

High

522386

HSPA9
Stress-70 protein, mitochondrial

1

9

High-throughput

0.479

High

522387

MDHM
Malate dehydrogenase, mitochondrial

1

4

High-throughput

0.479

High

522391

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

2

High-throughput

0.479

High

522392

EFTS
Elongation factor Ts, mitochondrial

1

3

High-throughput

0.479

High

522394

IF2M
Translation initiation factor IF-2, mitochondrial

1

9

High-throughput

0.479

High

522395

YAP1
Transcriptional coactivator YAP1

1

7

Small-scale

0.479

High

522397

EFTU
Elongation factor Tu, mitochondrial

1

6

High-throughput

0.479

High

522407

KIF23
Kinesin-like protein KIF23

1

1

High-throughput

0.479

High

522409

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

2

High-throughput

0.479

High

522411

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

1

Small-scale

0.479

High

522412

QOR
Quinone oxidoreductase

1

4

High-throughput

0.479

High

522413

MPPA
Mitochondrial-processing peptidase subunit alpha

1

10

High-throughput

0.479

High

522418

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

6

High-throughput

0.479

High

522419

ICT1
Large ribosomal subunit protein mL62

1

2

High-throughput

0.479

High

522430

SURF1
Surfeit locus protein 1

1

1

High-throughput

0.479

High

522434

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

3

High-throughput

0.479

High

522437

SYAM
Alanine--tRNA ligase, mitochondrial

1

2

High-throughput

0.479

High

522444

MRM1
rRNA methyltransferase 1, mitochondrial

1

2

High-throughput

0.479

High

522446

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

1

6

High-throughput

0.479

High

522450

COX15
Heme A synthase COX15

1

1

High-throughput

0.479

High

522451

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

9

High-throughput

0.479

High

522456

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

2

High-throughput

0.479

High

522471

FAKD4
FAST kinase domain-containing protein 4

1

9

High-throughput

0.479

High

522472

MCUR1
Mitochondrial calcium uniporter regulator 1

1

3

High-throughput

0.479

High

522473

CHCH1
Small ribosomal subunit protein mS37

1

1

High-throughput

0.479

High

522475

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

6

High-throughput

0.479

High

522476

RRFM
Ribosome-recycling factor, mitochondrial

1

3

High-throughput

0.479

High

522479

EFGM
Elongation factor G, mitochondrial

1

8

High-throughput

0.479

High

522483

TIM29
Mitochondrial import inner membrane translocase subunit Tim29

1

1

High-throughput

0.479

High

522484

TACO1
Translational activator of cytochrome c oxidase 1

1

3

High-throughput

0.479

High

522485

CQ080
Mitochondrial nucleoid-associated protein 1

1

3

High-throughput

0.479

High

522486

MTG1
Mitochondrial ribosome-associated GTPase 1

1

2

High-throughput

0.479

High

522487

TR61B
tRNA

1

2

High-throughput

0.479

High

522488

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

3

High-throughput

0.479

High

522489

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

1

High-throughput

0.479

High

522492

RT26
Small ribosomal subunit protein mS26

1

3

High-throughput

0.479

High

522495

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

4

High-throughput

0.479

High

522497

IF3M
Translation initiation factor IF-3, mitochondrial

1

2

High-throughput

0.479

High

522499

MTRFR
Mitochondrial translation release factor in rescue

1

10

High-throughput

0.479

High

522501

MTG2
Mitochondrial ribosome-associated GTPase 2

1

6

High-throughput

0.479

High

522504

MET17
Ribosome assembly protein METTL17, mitochondrial

1

4

High-throughput

0.479

High

522505

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

3

High-throughput

0.479

High

522506

SFXN1
Sideroflexin-1

1

3

High-throughput

0.479

High

522509

NGRN
Neugrin

1

1

High-throughput

0.479

High

522514

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

2

High-throughput

0.479

High

522515

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

4

High-throughput

0.479

High

522516

AKIP
Small ribosomal subunit protein mS38

1

1

High-throughput

0.479

High

522520

MRES1
Mitochondrial transcription rescue factor 1

1

3

High-throughput

0.479

High

522524

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

10

High-throughput

0.479

High

522529

RM11
Large ribosomal subunit protein uL11m

1

3

High-throughput

0.479

High

522530

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

2

Small-scale

0.479

High

522531

DJC15
DnaJ homolog subfamily C member 15

1

2

High-throughput

0.479

High

188794

TMPS2
Transmembrane protease serine 2

1

4

High-throughput

0.470

High

522465

CLC4D
C-type lectin domain family 4 member D

1

2

High-throughput

0.470

High

481056

HMGB1
High mobility group protein B1

1

7

Small-scale

0.464

High

486888

PARP1
Poly [ADP-ribose] polymerase 1

1

0

High-throughput

0.458

High

505407

CISD3
CDGSH iron-sulfur domain-containing protein 3, mitochondrial

1

0

High-throughput

0.458

High

522519

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.458

High

522525

KS6A6
Ribosomal protein S6 kinase alpha-6

1

0

High-throughput

0.458

High

522371

TAL1
T-cell acute lymphocytic leukemia protein 1

1

2

High-throughput

0.457

High

522438

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

High-throughput

0.445

High

522494

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

3

High-throughput

0.445

High

522513

SIR3
NAD-dependent protein deacetylase sirtuin-3, mitochondrial

1

5

High-throughput

0.445

High

125172

LEG9
Galectin-9

1

3

High-throughput

0.437

High

159480

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

2

High-throughput

0.437

High

256751

H2B1K
Histone H2B type 1-K

1

1

High-throughput

0.437

High

271849

OBSL1
Obscurin-like protein 1

1

2

High-throughput

0.437

High

293104

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.437

High

315047

RECQ4
ATP-dependent DNA helicase Q4

1

4

High-throughput

0.437

High

323128

TRI37
E3 ubiquitin-protein ligase TRIM37

1

5

High-throughput

0.437

High

348946

LATS1
Serine/threonine-protein kinase LATS1

1

4

High-throughput

0.437

High

352303

TOP3B
DNA topoisomerase 3-beta-1

1

3

High-throughput

0.437

High

405723

MYCN
N-myc proto-oncogene protein

1

3

High-throughput

0.437

High

459203

CATL1
Procathepsin L

1

1

High-throughput

0.437

High

522367

IFM1
Interferon-induced transmembrane protein 1

1

3

High-throughput

0.437

High

522368

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.437

High

522370

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

522373

CBL
E3 ubiquitin-protein ligase CBL

1

2

High-throughput

0.437

High

522374

BRD2
Bromodomain-containing protein 2

1

7

High-throughput

0.437

High

522376

DPP4
Dipeptidyl peptidase 4

1

1

High-throughput

0.437

High

522377

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

522379

PML
Protein PML

1

5

High-throughput

0.437

High

522381

STIP1
Stress-induced-phosphoprotein 1

1

5

High-throughput

0.437

High

522383

MERL
Merlin

1

3

High-throughput

0.437

High

522384

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

522388

CCNF
Cyclin-F

1

1

High-throughput

0.437

High

522398

LRBA
Lipopolysaccharide-responsive and beige-like anchor protein

1

2

High-throughput

0.437

High

522400

RAB9A
Ras-related protein Rab-9A

1

4

High-throughput

0.437

High

522403

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.437

High

522404

RHOG
Rho-related GTP-binding protein RhoG

1

6

High-throughput

0.437

High

522406

IFM3
Interferon-induced transmembrane protein 3

1

3

High-throughput

0.437

High

522410

UBE3A
Ubiquitin-protein ligase E3A

1

4

High-throughput

0.437

High

522415

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

2

High-throughput

0.437

High

522416

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.437

High

522420

RBM39
RNA-binding protein 39

1

2

High-throughput

0.437

High

522421

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

3

Small-scale

0.437

High

522425

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

6

High-throughput

0.437

High

522426

KIF14
Kinesin-like protein KIF14

1

2

High-throughput

0.437

High

522431

EZH2
Histone-lysine N-methyltransferase EZH2

1

7

High-throughput

0.437

High

522435

DJC21
DnaJ homolog subfamily C member 21

1

3

High-throughput

0.437

High

522439

SYDE2
Rho GTPase-activating protein SYDE2

1

3

High-throughput

0.437

High

522443

VIR
Protein virilizer homolog

1

1

High-throughput

0.437

High

522448

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.437

High

522454

TM11B
Transmembrane protease serine 11B

1

4

High-throughput

0.437

High

522457

CUL9
Cullin-9

1

1

High-throughput

0.437

High

522459

RHG24
Rho GTPase-activating protein 24

1

2

High-throughput

0.437

High

522460

FBXW8
F-box/WD repeat-containing protein 8

1

3

High-throughput

0.437

High

522463

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.437

High

522466

TITIN
Titin

1

2

High-throughput

0.437

High

522467

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.437

High

522470

H2B1H
Histone H2B type 1-H

1

1

High-throughput

0.437

High

522474

ARMC5
Armadillo repeat-containing protein 5

1

3

High-throughput

0.437

High

522482

ANM1
Protein arginine N-methyltransferase 1

1

2

High-throughput

0.437

High

522493

RHG39
Rho GTPase-activating protein 39

1

2

High-throughput

0.437

High

522498

BACD3
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

1

3

Small-scale

0.437

High

522502

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.437

High

522508

DNJC4
DnaJ homolog subfamily C member 4

1

7

High-throughput

0.437

High

522510

TF7L2
Transcription factor 7-like 2

1

2

High-throughput

0.437

High

522511

ANLN
Anillin

1

2

High-throughput

0.437

High

522512

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

5

High-throughput

0.437

High

522517

DJC28
DnaJ homolog subfamily C member 28

1

1

High-throughput

0.437

High

522518

TLS1
Splicing factor C9orf78

1

1

High-throughput

0.437

High

522522

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

2

High-throughput

0.437

High

522527

CLC4E
C-type lectin domain family 4 member E

1

2

High-throughput

0.437

High

402827

ANXA1
Annexin A1

1

2

Small-scale

0.407

High

404633

PRIO
Major prion protein

1

1

High-throughput

0.407

High

429190

JUN
Transcription factor Jun

1

3

High-throughput

0.407

High

522390

CNDD3
Condensin-2 complex subunit D3

1

3

High-throughput

0.407

High

522441

CP135
Centrosomal protein of 135 kDa

1

9

High-throughput

0.407

High

522442

A16L1
Autophagy-related protein 16-1

1

6

High-throughput

0.407

High

522452

S36A1
Proton-coupled amino acid transporter 1

1

1

High-throughput

0.407

High

522458

CNTRB
Centrobin

1

5

High-throughput

0.407

High

522462

POC5
Centrosomal protein POC5

1

3

High-throughput

0.407

High

522496

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

3

High-throughput

0.407

High

522500

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

3

High-throughput

0.407

High

522503

VIAAT
Vesicular inhibitory amino acid transporter

1

1

High-throughput

0.407

High

522477

DOCK6
Dedicator of cytokinesis protein 6

2

0

High-throughput

0.298

High

522453

HEAT3
HEAT repeat-containing protein 3

1

0

High-throughput

0.279

Low

458251

ADRB2
Beta-2 adrenergic receptor

1

0

High-throughput

0.249

Low

522375

PSA3
Proteasome subunit alpha type-3

1

0

Small-scale

0.249

Low

522382

HPPD
4-hydroxyphenylpyruvate dioxygenase

1

0

Small-scale

0.249

Low

522405

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

Small-scale

0.249

Low

522408

K1C17
Keratin, type I cytoskeletal 17

1

0

High-throughput

0.249

Low

522423

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.249

Low

522424

PAF15
PCNA-associated factor

1

0

Small-scale

0.249

Low

522432

IF16
Gamma-interferon-inducible protein 16

1

0

High-throughput

0.249

Low

522433

CDKN3
Cyclin-dependent kinase inhibitor 3

1

0

High-throughput

0.249

Low

522436

EMC4
ER membrane protein complex subunit 4

1

0

High-throughput

0.249

Low

522461

UBR7
Putative E3 ubiquitin-protein ligase UBR7

1

0

High-throughput

0.249

Low

522478

BROMI
Protein broad-minded

1

0

Small-scale

0.249

Low

522481

TS101
Tumor susceptibility gene 101 protein

1

0

Small-scale

0.249

Low

522491

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.249

Low

522507

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

0

High-throughput

0.249

Low

522528

DLEC1
Deleted in lung and esophageal cancer protein 1

1

0

High-throughput

0.249

Low

522422

NPT1
Sodium-dependent phosphate transport protein 1

1

0

High-throughput

0.232

Low

522445

MFS12
Major facilitator superfamily domain-containing protein 12

1

0

High-throughput

0.232

Low

522464

CTL5
Choline transporter-like protein 5

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025