HitPredict

Interactor 1: NKX25 (P42582)
Homeobox protein Nkx-2.5 (Cardiac-specific homeobox) (Homeobox protein CSX) (Homeobox protein NK-2 homolog E)
Gene: Nkx2-5

Interactor 2: TBX5 (P70326)
T-box transcription factor TBX5 (T-box protein 5)
Gene: TBX5

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.58 1.00 0.768

The method score is based on:

Property Details
Experiments 11572777, 28164238
Identification Methods pull down
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Homeodomain~T-box
Common GO terms GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003166 - bundle of His development
GO:0003677 - DNA binding
and 19 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 318
Mm

1 518
+ Hs
+ Mm
+ Mm
+ Hs
+ Mm
+ Mm
+ Mm
+ Hs
+ Ce
+ Dm
+ Ce
+ Ce
+ Ce
+ Ce
+ Ce
+ Ce
+ Dm
+ Dm
+ Dm
+ Dm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024