HitPredict

Interactor 1: NKX25 (P42582)
Homeobox protein Nkx-2.5 (Cardiac-specific homeobox) (Homeobox protein CSX) (Homeobox protein NK-2 homolog E)
Gene: Nkx2-5

Interactor 2: GATA4 (Q08369)
Transcription factor GATA-4 (GATA-binding factor 4)
Gene: GATA4

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.60 0.60 0.601

The method score is based on:

Property Details
Experiments 12845333, 9584153
Identification Methods anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, pull down
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001947 - heart looping
and 20 others

more...
Homologous interactions 9

Homologous interactions

Color coding for hit scores

1 318
Mm

1 441
+ Hs
+ Hs
+ Mm
+ Mm
+ Hs
+ Dm
+ Hs
+ Dm
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024