HitPredict

Interactor 1: HD (P42858)
Huntingtin (Huntington disease protein) (HD protein) [Cleaved into: Huntingtin, myristoylated N-terminal fragment]
Gene: HTT

Interactor 2: DPYL2 (Q16555)
Dihydropyrimidinase-related protein 2 (DRP-2) (Collapsin response mediator protein 2) (CRMP-2) (N2A3) (Unc-33-like phosphoprotein 2) (ULIP-2)
Gene: DPYSL2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.57	0.60	0.588

Property	Details
Experiments	32814053, 17500595
Identification Methods	two hybrid array, two hybrid pooling approach, validated two hybrid, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 3142 Hs			1 572
+	Hs
		791556 HD_HUMAN (1-3142): 0: 5724: 100.00		DPYL1_HUMAN (1-572): 0: 761: 76.22
+	Hs
		791913 HD_HUMAN (1-3142): 0: 5724: 100.00		DPYL5_HUMAN (9-567): 0: 653: 51.34
+	Mm
		102680 G3X9H5_MOUSE (81-3142): 0: 5479: 91.19		DPYL2_MOUSE (1-572): 0: 768: 98.78
+	Mm
		102985 G3X9H5_MOUSE (81-3142): 0: 5479: 91.19		DPYL1_MOUSE (1-572): 0: 752: 76.22
+	Mm
		103055 G3X9H5_MOUSE (81-3142): 0: 5479: 91.19		DPYL3_MOUSE (1-571): 0: 743: 76.18
+	Hs
		653184 HD_HUMAN (1-3142): 0: 5724: 100.00		PYR1_HUMAN (26-564): 2.07e-135: 436: 18.61