Protein: STAM2
Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein)

Gene: STAM2
Organism: Homo sapiens
Interactions: 225
UniProt ID: O75886

Gene Ontology (top 5):
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0007165 - signal transduction
GO:0016236 - macroautophagy

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

296426

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

12

20

Small-scale

0.977

High

169355

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

7

18

Small-scale

0.961

High

296580

ABI2
Abl interactor 2

4

20

High-throughput

0.911

High

296491

LCP2
Lymphocyte cytosolic protein 2

4

19

Small-scale

0.905

High

296415

EGFR
Epidermal growth factor receptor

4

20

Small-scale

0.886

High

296546

ARRD3
Arrestin domain-containing protein 3

3

10

High-throughput

0.871

High

296589

UBQL2
Ubiquilin-2

3

17

High-throughput

0.843

High

296591

UBQL1
Ubiquilin-1

3

17

Small-scale

0.843

High

240313

PRKN
E3 ubiquitin-protein ligase parkin

3

16

High-throughput

0.839

High

296540

STAM1
Signal transducing adapter molecule 1

2

19

High-throughput

0.811

High

296439

JAK1
Tyrosine-protein kinase JAK1

2

20

Small-scale

0.799

High

296548

PKHB2
Pleckstrin homology domain-containing family B member 2

3

2

High-throughput

0.779

High

296412

STABP
STAM-binding protein

6

3

Small-scale

0.741

High

296570

SH24A
SH2 domain-containing protein 4A

1

20

High-throughput

0.740

High

296554

LITAF
Lipopolysaccharide-induced tumor necrosis factor-alpha factor

5

3

High-throughput

0.725

High

296498

DAZP2
DAZ-associated protein 2

4

3

High-throughput

0.705

High

296567

PTN23
Tyrosine-protein phosphatase non-receptor type 23

4

20

Small-scale

0.698

High

296575

UBQL4
Ubiquilin-4

1

18

High-throughput

0.698

High

296452

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

4

10

Small-scale

0.689

High

63160

VP37C
Vacuolar protein sorting-associated protein 37C

3

20

High-throughput

0.675

High

296585

KLH42
Kelch-like protein 42

3

2

High-throughput

0.675

High

296444

EPHA2
Ephrin type-A receptor 2

2

20

High-throughput

0.675

High

296470

ATX1
Ataxin-1

3

2

High-throughput

0.666

High

245833

KIF1B
Kinesin-like protein KIF1B

1

8

High-throughput

0.665

High

296425

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

20

High-throughput

0.665

High

238689

TIM8A
Mitochondrial import inner membrane translocase subunit Tim8 A

4

1

High-throughput

0.647

High

296550

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

20

Small-scale

0.647

High

296594

RNF11
RING finger protein 11

4

9

Small-scale

0.639

High

296543

LMBL2
Lethal(3)malignant brain tumor-like protein 2

3

0

High-throughput

0.639

High

188750

TMPS2
Transmembrane protease serine 2

1

2

High-throughput

0.618

High

253261

JAK2
Tyrosine-protein kinase JAK2

1

20

Small-scale

0.618

High

296411

ZFYV9
Zinc finger FYVE domain-containing protein 9

1

20

Small-scale

0.618

High

296418

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.618

High

296421

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

20

High-throughput

0.618

High

296422

PGFRB
Platelet-derived growth factor receptor beta

1

20

High-throughput

0.618

High

296429

FGFR1
Fibroblast growth factor receptor 1

1

20

High-throughput

0.618

High

296432

PGFRA
Platelet-derived growth factor receptor alpha

1

20

High-throughput

0.618

High

296435

FGFR2
Fibroblast growth factor receptor 2

1

20

High-throughput

0.618

High

296445

EPHA3
Ephrin type-A receptor 3

1

20

High-throughput

0.618

High

296446

EPHA8
Ephrin type-A receptor 8

1

20

High-throughput

0.618

High

296447

TYK2
Non-receptor tyrosine-protein kinase TYK2

1

20

Small-scale

0.618

High

296448

RYK
Tyrosine-protein kinase RYK

1

20

High-throughput

0.618

High

296465

JAK3
Tyrosine-protein kinase JAK3

1

20

Small-scale

0.618

High

296472

EPHA4
Ephrin type-A receptor 4

1

20

High-throughput

0.618

High

296509

NTRK3
NT-3 growth factor receptor

1

20

High-throughput

0.618

High

296510

NTRK2
BDNF/NT-3 growth factors receptor

1

20

High-throughput

0.618

High

296519

ZFY16
Zinc finger FYVE domain-containing protein 16

1

20

Small-scale

0.618

High

296522

MIB1
E3 ubiquitin-protein ligase MIB1

1

12

High-throughput

0.618

High

296590

ALK
ALK tyrosine kinase receptor

1

20

High-throughput

0.618

High

296494

RIN1
Ras and Rab interactor 1

2

9

Small-scale

0.612

High

132418

CDC7
Cell division cycle 7-related protein kinase

2

7

High-throughput

0.606

High

296598

KCNE3
Potassium voltage-gated channel subfamily E member 3

2

3

High-throughput

0.601

High

296506

EREP1
Endosomal transmembrane epsin interactor 1

2

3

High-throughput

0.595

High

296438

FGFR3
Fibroblast growth factor receptor 3

1

20

High-throughput

0.594

High

296588

EPHA6
Ephrin type-A receptor 6

1

20

High-throughput

0.578

High

48464

ESYT2
Extended synaptotagmin-2

1

4

High-throughput

0.575

High

296483

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

20

High-throughput

0.575

High

296523

PACE1
Protein-associating with the carboxyl-terminal domain of ezrin

1

4

High-throughput

0.575

High

296558

ESYT1
Extended synaptotagmin-1

1

7

High-throughput

0.575

High

296564

RGAP1
Rac GTPase-activating protein 1

1

8

High-throughput

0.575

High

296434

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

17

Small-scale

0.561

High

296437

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.553

High

296471

EPHA5
Ephrin type-A receptor 5

1

20

High-throughput

0.553

High

296503

EPHA7
Ephrin type-A receptor 7

1

20

High-throughput

0.553

High

296535

PHF10
PHD finger protein 10

1

1

High-throughput

0.541

High

296423

PARP1
Poly [ADP-ribose] polymerase 1

1

4

High-throughput

0.536

High

296440

1433T
14-3-3 protein theta

1

20

High-throughput

0.536

High

296449

COPB2
Coatomer subunit beta'

1

5

High-throughput

0.536

High

296468

COPA
Coatomer subunit alpha

1

5

High-throughput

0.536

High

296469

IST1
IST1 homolog

1

2

High-throughput

0.536

High

296478

1433G
14-3-3 protein gamma

1

20

High-throughput

0.536

High

296489

1433F
14-3-3 protein eta

1

20

High-throughput

0.536

High

296539

HS105
Heat shock protein 105 kDa

1

12

High-throughput

0.536

High

296549

MB12A
Multivesicular body subunit 12A

1

5

High-throughput

0.536

High

296555

TS101
Tumor susceptibility gene 101 protein

1

14

High-throughput

0.536

High

296416

RASH
GTPase HRas

1

19

High-throughput

0.515

High

296417

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

20

High-throughput

0.515

High

296451

SYUA
Alpha-synuclein

1

2

High-throughput

0.515

High

296455

HD
Huntingtin

1

4

High-throughput

0.515

High

296458

TCPE
T-complex protein 1 subunit epsilon

1

6

High-throughput

0.515

High

296495

DCTN1
Dynactin subunit 1

1

9

High-throughput

0.515

High

296464

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

4

Small-scale

0.501

High

296476

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

4

Small-scale

0.501

High

296479

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

7

Small-scale

0.501

High

296481

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

4

Small-scale

0.501

High

296493

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

11

Small-scale

0.501

High

296475

PRPS1
Ribose-phosphate pyrophosphokinase 1

1

0

High-throughput

0.493

High

296541

APBB2
Amyloid beta precursor protein binding family B member 2

1

0

High-throughput

0.493

High

296524

XRN1
5'-3' exoribonuclease 1

1

0

High-throughput

0.486

High

126405

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.479

High

164199

NRP1
Neuropilin-1

1

4

High-throughput

0.479

High

172339

XPO1
Exportin-1

1

6

High-throughput

0.479

High

217627

TGON2
Trans-Golgi network integral membrane protein 2

1

17

High-throughput

0.479

High

225888

STX6
Syntaxin-6

1

9

High-throughput

0.479

High

296405

NFAT5
Nuclear factor of activated T-cells 5

1

7

Small-scale

0.479

High

296406

SC31A
Protein transport protein Sec31A

1

8

Small-scale

0.479

High

296428

LAMP1
Lysosome-associated membrane glycoprotein 1

1

4

High-throughput

0.479

High

296433

CXA1
Gap junction alpha-1 protein

1

13

High-throughput

0.479

High

296441

DPP4
Dipeptidyl peptidase 4

1

1

High-throughput

0.479

High

296453

CCNF
Cyclin-F

1

3

High-throughput

0.479

High

296454

EPS15
Epidermal growth factor receptor substrate 15

1

18

Small-scale

0.479

High

296466

PLK1
Serine/threonine-protein kinase PLK1

1

9

High-throughput

0.479

High

296473

SEC13
Protein SEC13 homolog

1

2

Small-scale

0.479

High

296474

TPTE
Putative tyrosine-protein phosphatase TPTE

1

7

High-throughput

0.479

High

296480

RHOB
Rho-related GTP-binding protein RhoB

1

17

High-throughput

0.479

High

296482

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

4

High-throughput

0.479

High

296487

IFM3
Interferon-induced transmembrane protein 3

1

11

High-throughput

0.479

High

296488

CAV1
Caveolin-1

1

7

High-throughput

0.479

High

296490

STX4
Syntaxin-4

1

15

High-throughput

0.479

High

296507

EZH2
Histone-lysine N-methyltransferase EZH2

1

3

High-throughput

0.479

High

296508

CCDC6
Coiled-coil domain-containing protein 6

1

17

High-throughput

0.479

High

296511

OCLN
Occludin

1

3

High-throughput

0.479

High

296516

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

296518

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.479

High

296520

NAA40
N-alpha-acetyltransferase 40

1

2

High-throughput

0.479

High

296533

FBF1
Fas-binding factor 1

1

19

High-throughput

0.479

High

296563

WWTR1
WW domain-containing transcription regulator protein 1

1

20

High-throughput

0.479

High

296568

DNJC5
DnaJ homolog subfamily C member 5

1

9

High-throughput

0.479

High

296569

RHOJ
Rho-related GTP-binding protein RhoJ

1

19

High-throughput

0.479

High

296571

TMT1A
Thiol S-methyltransferase TMT1A

1

2

High-throughput

0.479

High

296572

RHOF
Rho-related GTP-binding protein RhoF

1

19

High-throughput

0.479

High

296584

TM216
Transmembrane protein 216

1

1

High-throughput

0.479

High

296586

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

3

High-throughput

0.479

High

109352

G5E9A7
DM1 locus, WD repeat containing

1

2

High-throughput

0.470

High

296534

Q8WU02
C9orf61 protein

1

1

High-throughput

0.470

High

296545

COQA1
Collagen alpha-1(XXVI) chain

1

1

High-throughput

0.470

High

296560

NUP58
Nucleoporin p58/p45

1

2

High-throughput

0.470

High

289894

OFD1
Centriole and centriolar satellite protein OFD1

1

0

High-throughput

0.458

High

158067

COPE
Coatomer subunit epsilon

1

2

High-throughput

0.445

High

215467

EMC8
ER membrane protein complex subunit 8

1

2

High-throughput

0.445

High

296404

MICA2
[F-actin]-monooxygenase MICAL2

1

20

High-throughput

0.445

High

296409

VENTX
Homeobox protein VENTX

1

7

High-throughput

0.445

High

296410

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

2

High-throughput

0.445

High

296414

NB5R3
NADH-cytochrome b5 reductase 3

1

1

High-throughput

0.445

High

296420

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

4

High-throughput

0.445

High

296427

BIP
Endoplasmic reticulum chaperone BiP

1

8

High-throughput

0.445

High

296431

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

2

High-throughput

0.445

High

296442

CALR
Calreticulin

1

1

High-throughput

0.445

High

296460

AL7A1
Alpha-aminoadipic semialdehyde dehydrogenase

1

1

High-throughput

0.445

High

296467

COPB
Coatomer subunit beta

1

15

High-throughput

0.445

High

296477

COPZ1
Coatomer subunit zeta-1

1

4

High-throughput

0.445

High

296485

ARF5
ADP-ribosylation factor 5

1

20

High-throughput

0.445

High

296492

PRDX4
Peroxiredoxin-4

1

3

High-throughput

0.445

High

296497

EMC2
ER membrane protein complex subunit 2

1

6

High-throughput

0.445

High

296499

AR6P1
ADP-ribosylation factor-like protein 6-interacting protein 1

1

1

High-throughput

0.445

High

296502

TMED2
Transmembrane emp24 domain-containing protein 2

1

4

High-throughput

0.445

High

296515

LCLT1
Lysocardiolipin acyltransferase 1

1

1

High-throughput

0.445

High

296517

UB2R2
Ubiquitin-conjugating enzyme E2 R2

1

6

High-throughput

0.445

High

296528

DHB11
Estradiol 17-beta-dehydrogenase 11

1

2

High-throughput

0.445

High

296530

VP37A
Vacuolar protein sorting-associated protein 37A

1

9

High-throughput

0.445

High

296536

SCFD1
Sec1 family domain-containing protein 1

1

5

High-throughput

0.445

High

296552

SCYL1
N-terminal kinase-like protein

1

7

High-throughput

0.445

High

296553

NUDC1
NudC domain-containing protein 1

1

1

High-throughput

0.445

High

296583

VAPA
Vesicle-associated membrane protein-associated protein A

1

2

High-throughput

0.445

High

296587

COPG2
Coatomer subunit gamma-2

1

20

High-throughput

0.445

High

296596

COPG1
Coatomer subunit gamma-1

1

20

High-throughput

0.445

High

139784

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

3

High-throughput

0.437

High

179772

BET1
BET1 homolog

1

9

High-throughput

0.437

High

296402

FLOT1
Flotillin-1

1

5

High-throughput

0.437

High

296407

ZFPL1
Zinc finger protein-like 1

1

5

High-throughput

0.437

High

296413

DIRA3
GTP-binding protein Di-Ras3

1

15

High-throughput

0.437

High

296419

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

1

High-throughput

0.437

High

296424

FURIN
Furin

1

4

High-throughput

0.437

High

296430

IFM1
Interferon-induced transmembrane protein 1

1

11

High-throughput

0.437

High

296436

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

3

High-throughput

0.437

High

296450

BASI
Basigin

1

7

High-throughput

0.437

High

296513

LTOR1
Ragulator complex protein LAMTOR1

1

4

High-throughput

0.437

High

296514

RHDF2
Inactive rhomboid protein 2

1

2

High-throughput

0.437

High

296521

TMM17
Transmembrane protein 17

1

4

High-throughput

0.437

High

296525

CXD3
Gap junction delta-3 protein

1

13

High-throughput

0.437

High

296538

CLC4D
C-type lectin domain family 4 member D

1

3

High-throughput

0.437

High

296542

PTPR2
Receptor-type tyrosine-protein phosphatase N2

1

10

High-throughput

0.437

High

296578

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

1

High-throughput

0.437

High

60276

NBAS
NBAS subunit of NRZ tethering complex

1

0

High-throughput

0.426

High

211702

ZW10
Centromere/kinetochore protein zw10 homolog

1

0

High-throughput

0.426

High

213544

VIP2
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2

1

0

High-throughput

0.426

High

296457

COPD
Coatomer subunit delta

1

0

High-throughput

0.426

High

296459

KC1A
Casein kinase I isoform alpha

1

0

High-throughput

0.426

High

296463

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.426

High

296484

NUCB2
Nucleobindin-2

1

0

High-throughput

0.426

High

296496

GANAB
Neutral alpha-glucosidase AB

1

0

High-throughput

0.426

High

296500

RB3GP
Rab3 GTPase-activating protein catalytic subunit

1

0

High-throughput

0.426

High

296504

DHC24
Delta(24)-sterol reductase

1

0

High-throughput

0.426

High

296544

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

0

High-throughput

0.426

High

296547

ASTRA
Protein Aster-A

1

0

High-throughput

0.426

High

296556

PXL2A
Peroxiredoxin-like 2A

1

0

High-throughput

0.426

High

296559

NDC1
Nucleoporin NDC1

1

0

High-throughput

0.426

High

296561

WDR11
WD repeat-containing protein 11

1

0

High-throughput

0.426

High

296562

LNP
Endoplasmic reticulum junction formation protein lunapark

1

0

High-throughput

0.426

High

296565

RBGPR
Rab3 GTPase-activating protein non-catalytic subunit

1

0

High-throughput

0.426

High

296595

SERC
Phosphoserine aminotransferase

1

0

High-throughput

0.426

High

296456

CBX5
Chromobox protein homolog 5

1

1

Small-scale

0.408

High

50460

HACL2
2-hydroxyacyl-CoA lyase 2

1

1

High-throughput

0.407

High

104309

F5H6I7
Atlastin GTPase 3

1

2

High-throughput

0.407

High

117800

M0QZK6
Multivesicular body subunit 12A

1

5

High-throughput

0.407

High

275473

RTN2
Reticulon-2

1

3

High-throughput

0.407

High

296408

RTN3
Reticulon-3

1

3

High-throughput

0.407

High

296443

CALX
Calnexin

1

1

High-throughput

0.407

High

296461

TMEDA
Transmembrane emp24 domain-containing protein 10

1

4

High-throughput

0.407

High

296501

RCN1
Reticulocalbin-1

1

1

High-throughput

0.407

High

296512

DHB12
Very-long-chain 3-oxoacyl-CoA reductase

1

3

High-throughput

0.407

High

296529

PDZD8
PDZ domain-containing protein 8

1

2

High-throughput

0.407

High

296531

ATLA2
Atlastin-2

1

2

High-throughput

0.407

High

296537

ATLA1
Atlastin-1

1

2

High-throughput

0.407

High

296557

ERP44
Endoplasmic reticulum resident protein 44

1

2

High-throughput

0.407

High

296566

TMX1
Thioredoxin-related transmembrane protein 1

1

2

High-throughput

0.407

High

296574

RTN4
Reticulon-4

1

4

High-throughput

0.407

High

296576

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

6

High-throughput

0.407

High

296581

PSD3
PH and SEC7 domain-containing protein 3

1

4

High-throughput

0.407

High

296592

DHRS7
Dehydrogenase/reductase SDR family member 7

1

2

High-throughput

0.407

High

296593

TMED5
Transmembrane emp24 domain-containing protein 5

1

4

High-throughput

0.407

High

296551

ZC3HA
Zinc finger CCCH domain-containing protein 10

2

0

High-throughput

0.316

High

296597

PTC2
Protein patched homolog 2

1

0

High-throughput

0.279

Low

296403

WFS1
Wolframin

1

0

High-throughput

0.268

Low

283163

ERLN1
Erlin-1

1

0

High-throughput

0.232

Low

296462

SSRD
Translocon-associated protein subunit delta

1

0

High-throughput

0.232

Low

296486

REEP5
Receptor expression-enhancing protein 5

1

0

High-throughput

0.232

Low

296505

NSDHL
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

1

0

High-throughput

0.232

Low

296526

CISD2
CDGSH iron-sulfur domain-containing protein 2

1

0

High-throughput

0.232

Low

296527

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.232

Low

296532

MCFD2
Multiple coagulation factor deficiency protein 2

1

0

High-throughput

0.232

Low

296573

APMAP
Adipocyte plasma membrane-associated protein

1

0

High-throughput

0.232

Low

296577

TM38B
Trimeric intracellular cation channel type B

1

0

High-throughput

0.232

Low

296579

GPTC2
G patch domain-containing protein 2

1

0

High-throughput

0.232

Low

296582

TECR
Very-long-chain enoyl-CoA reductase

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025