HitPredict

Interactor 1: GDF5 (P43026)
Growth/differentiation factor 5 (GDF-5) (Bone morphogenetic protein 14) (BMP-14) (Cartilage-derived morphogenetic protein 1) (CDMP-1) (Lipopolysaccharide-associated protein 4) (LAP-4) (LPS-associated protein 4) (Radotermin)
Gene: GDF5

Interactor 2: ACVR1 (Q04771)
Activin receptor type-1 (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Activin receptor-like kinase 2) (ALK-2) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I)
Gene: ACVR1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	8702914
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Activin_recp~TGF_beta
Common GO terms	GO:0005886 - plasma membrane GO:0007179 - transforming growth factor beta receptor signaling pathway GO:0030509 - BMP signaling pathway GO:0060391 - positive regulation of SMAD protein signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 501 Hs			1 509
+	Hs
		738309 GDF5_HUMAN (1-501): 0: 605: 100.00		BMR1A_HUMAN (25-503): 1.29e-137: 409: 49.79
+	Hs
		122285 GDF5_HUMAN (1-501): 0: 605: 100.00		BMR1B_HUMAN (22-503): 5.09e-136: 404: 50.31
+	Hs
		792921 GDF5_HUMAN (1-501): 0: 605: 100.00		BMPR2_HUMAN (49-507): 3.21e-105: 339: 30.66
+	Hs
		792920 GDF5_HUMAN (1-501): 0: 605: 100.00		AVR2B_HUMAN (46-509): 4.4e-107: 330: 29.46
+	Hs
		646022 GDF5_HUMAN (1-501): 0: 605: 100.00		AVR2A_HUMAN (52-508): 7.82e-102: 316: 29.33
+	Hs
		574199 BMP7_HUMAN (109-500): 1.76e-108: 331: 24.59		ACVR1_HUMAN (1-509): 3.82e-154: 450: 100.00
+	Hs
		520110 BMP4_HUMAN (108-501): 3.13e-115: 347: 27.64		BMR1A_HUMAN (25-503): 1.29e-137: 409: 49.79
+	Hs
		122281 BMP4_HUMAN (108-501): 3.13e-115: 347: 27.64		BMR1B_HUMAN (22-503): 5.09e-136: 404: 50.31
+	Dm
		429972 DECA_DROME (73-501): 2.28e-107: 333: 27.33		Q7JQ36_DROME (19-508): 3.72e-137: 409: 51.56
+	Dm
		429974 DECA_DROME (73-501): 2.28e-107: 333: 27.33		Q95U21_DROME (19-508): 1.75e-137: 409: 51.56
+	Hs
		574186 BMP7_HUMAN (109-500): 1.76e-108: 331: 24.59		BMR1A_HUMAN (25-503): 1.29e-137: 409: 49.79
+	Hs
		122282 BMP7_HUMAN (109-500): 1.76e-108: 331: 24.59		BMR1B_HUMAN (22-503): 5.09e-136: 404: 50.31
+	Dm
		429973 DECA_DROME (73-501): 2.28e-107: 333: 27.33		Q95SI0_DROME (22-509): 1.02e-123: 373: 43.58
+	Dm
		429971 DECA_DROME (73-501): 2.28e-107: 333: 27.33		Q24326_DROME (18-509): 3.55e-122: 370: 43.24
+	Hs
		520153 BMP4_HUMAN (108-501): 3.13e-115: 347: 27.64		BMPR2_HUMAN (49-507): 3.21e-105: 339: 30.66
+	Dm
		429970 DECA_DROME (73-501): 2.28e-107: 333: 27.33		Q24229_DROME (34-503): 6.15e-115: 350: 31.78
+	Hs
		574204 BMP7_HUMAN (109-500): 1.76e-108: 331: 24.59		BMPR2_HUMAN (49-507): 3.21e-105: 339: 30.66
+	Hs
		520099 BMP4_HUMAN (108-501): 3.13e-115: 347: 27.64		AVR2A_HUMAN (52-508): 7.82e-102: 316: 29.33
+	Hs
		574203 BMP7_HUMAN (109-500): 1.76e-108: 331: 24.59		AVR2B_HUMAN (46-509): 4.4e-107: 330: 29.46
+	Hs
		574181 BMP7_HUMAN (109-500): 1.76e-108: 331: 24.59		AVR2A_HUMAN (52-508): 7.82e-102: 316: 29.33