Protein: GAK
Cyclin-G-associated kinase (EC 2.7.11.1) (DnaJ homolog subfamily C member 26)

Gene: GAK
Organism: Homo sapiens
Interactions: 173
UniProt ID: O14976

Gene Ontology (top 5):
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005794 - Golgi apparatus
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

161670

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

4

16

Small-scale

0.914

High

161666

LRRK1
Leucine-rich repeat serine/threonine-protein kinase 1

2

8

High-throughput

0.778

High

161726

C5AR2
C5a anaphylatoxin chemotactic receptor 2

2

1

High-throughput

0.726

High

161616

HSP7C
Heat shock cognate 71 kDa protein

4

5

Small-scale

0.699

High

161587

AXIN1
Axin-1

1

1

High-throughput

0.698

High

160884

RAB7L
Ras-related protein Rab-7L1

1

2

Small-scale

0.691

High

161594

DNJA2
DnaJ homolog subfamily A member 2

1

8

High-throughput

0.691

High

161595

AUXI
Auxilin

1

13

High-throughput

0.691

High

161598

CIB2
Calcium and integrin-binding family member 2

1

20

High-throughput

0.691

High

161611

SP1
Transcription factor Sp1

1

3

High-throughput

0.691

High

161619

PHKG2
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform

1

18

High-throughput

0.691

High

161622

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

3

High-throughput

0.691

High

161636

IRAK1
Interleukin-1 receptor-associated kinase 1

1

7

High-throughput

0.691

High

161650

ACK1
Activated CDC42 kinase 1

1

20

High-throughput

0.691

High

161652

TNK1
Non-receptor tyrosine-protein kinase TNK1

1

20

High-throughput

0.691

High

161655

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

15

High-throughput

0.691

High

161660

CDC37
Hsp90 co-chaperone Cdc37

1

2

High-throughput

0.691

High

161665

AAK1
AP2-associated protein kinase 1

1

18

High-throughput

0.691

High

161689

CPSF7
Cleavage and polyadenylation specificity factor subunit 7

1

4

High-throughput

0.691

High

161691

ACTT1
Actin-related protein T1

1

3

High-throughput

0.691

High

161701

RBM14
RNA-binding protein 14

1

3

High-throughput

0.691

High

161705

RBM42
RNA-binding protein 42

1

4

High-throughput

0.691

High

161708

WNK3
Serine/threonine-protein kinase WNK3

1

18

High-throughput

0.691

High

161722

BMP2K
BMP-2-inducible protein kinase

1

16

High-throughput

0.691

High

161733

FEM1B
Protein fem-1 homolog B

1

5

High-throughput

0.691

High

161735

KDIS
Kinase D-interacting substrate of 220 kDa

1

4

High-throughput

0.691

High

161739

DAPP1
Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide

1

18

High-throughput

0.691

High

161638

CCNG1
Cyclin-G1

1

0

Small-scale

0.687

High

161596

HIP1R
Huntingtin-interacting protein 1-related protein

3

13

High-throughput

0.675

High

161699

STALP
AMSH-like protease

3

3

High-throughput

0.675

High

161602

STABP
STAM-binding protein

3

3

High-throughput

0.667

High

161612

CLCA
Clathrin light chain A

3

10

High-throughput

0.667

High

161613

CLCB
Clathrin light chain B

3

10

High-throughput

0.667

High

161651

DMWD
Dystrophia myotonica WD repeat-containing protein

3

9

High-throughput

0.667

High

161688

AFAP1
Actin filament-associated protein 1

1

0

High-throughput

0.656

High

161704

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.656

High

161584

GAK
Cyclin-G-associated kinase

1

18

Small-scale

0.647

High

161629

CCNF
Cyclin-F

1

0

High-throughput

0.631

High

161663

INF2
Inverted formin-2

2

4

High-throughput

0.628

High

161686

PALS1
Protein PALS1

2

5

High-throughput

0.628

High

161721

SYIM
Isoleucine--tRNA ligase, mitochondrial

2

3

High-throughput

0.628

High

161731

RABX5
Rab5 GDP/GTP exchange factor

2

1

High-throughput

0.628

High

161625

CALL3
Calmodulin-like protein 3

1

14

High-throughput

0.618

High

161700

PPM1M
Protein phosphatase 1M

1

17

High-throughput

0.618

High

161740

PSG11
Pregnancy-specific beta-1-glycoprotein 11

1

1

High-throughput

0.618

High

161607

NTRK1
High affinity nerve growth factor receptor

1

15

High-throughput

0.618

High

161621

RAB4A
Ras-related protein Rab-4A

1

4

High-throughput

0.618

High

161643

ARP3
Actin-related protein 3

1

3

High-throughput

0.618

High

161647

CDK5
Cyclin-dependent kinase 5

1

7

Small-scale

0.618

High

161662

PTPRO
Receptor-type tyrosine-protein phosphatase O

1

2

High-throughput

0.618

High

161678

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.618

High

161716

WNK1
Serine/threonine-protein kinase WNK1

1

18

High-throughput

0.618

High

161717

PKHA4
Pleckstrin homology domain-containing family A member 4

1

13

High-throughput

0.618

High

161738

ALK
ALK tyrosine kinase receptor

1

15

Small-scale

0.618

High

161648

CLH1
Clathrin heavy chain 1

2

9

High-throughput

0.611

High

161690

F174A
Membrane protein FAM174A

2

0

High-throughput

0.602

High

161656

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.586

High

161720

AT132
Polyamine-transporting ATPase 13A2

1

8

Small-scale

0.582

High

99455

F5GWT4
non-specific serine/threonine protein kinase

1

19

High-throughput

0.575

High

161592

PRKY
Putative serine/threonine-protein kinase PRKY

1

17

High-throughput

0.575

High

161654

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

14

High-throughput

0.575

High

161674

PKHA7
Pleckstrin homology domain-containing family A member 7

1

15

High-throughput

0.575

High

161684

CLASR
CLK4-associating serine/arginine rich protein

2

1

High-throughput

0.574

High

161724

HPBP1
Hsp70-binding protein 1

2

1

High-throughput

0.574

High

161736

CBLC
E3 ubiquitin-protein ligase CBL-C

2

1

High-throughput

0.574

High

161633

PAXI
Paxillin

2

9

High-throughput

0.571

High

161642

BCAR1
Breast cancer anti-estrogen resistance protein 1

2

6

High-throughput

0.571

High

161706

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

4

High-throughput

0.553

High

161593

USO1
General vesicular transport factor p115

1

12

High-throughput

0.541

High

161744

MFHA1
Malignant fibrous histiocytoma-amplified sequence 1

1

9

High-throughput

0.536

High

117512

MYO1C
Unconventional myosin-Ic

1

8

High-throughput

0.536

High

124341

HIP1
Huntingtin-interacting protein 1

1

16

High-throughput

0.536

High

128772

P3C2A
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

1

2

High-throughput

0.536

High

161585

SC16A
Protein transport protein Sec16A

1

3

High-throughput

0.536

High

161600

AP2A2
AP-2 complex subunit alpha-2

1

17

High-throughput

0.536

High

161601

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

1

2

High-throughput

0.536

High

161603

AP2A1
AP-2 complex subunit alpha-1

1

17

High-throughput

0.536

High

161604

BAG2
BAG family molecular chaperone regulator 2

1

4

High-throughput

0.536

High

161605

LGI1
Leucine-rich glioma-inactivated protein 1

1

6

High-throughput

0.536

High

161606

TGFA
Protransforming growth factor alpha [Cleaved into: Transforming growth factor alpha

1

2

High-throughput

0.536

High

161608

P53
Cellular tumor antigen p53

1

2

High-throughput

0.536

High

161614

PARP1
Poly [ADP-ribose] polymerase 1

1

12

High-throughput

0.536

High

161623

SAHH
Adenosylhomocysteinase

1

4

High-throughput

0.536

High

161624

S10A4
Protein S100-A4

1

7

High-throughput

0.536

High

161627

PSA5
Proteasome subunit alpha type-5

1

4

High-throughput

0.536

High

161630

EPS15
Epidermal growth factor receptor substrate 15

1

9

High-throughput

0.536

High

161631

RL5
Large ribosomal subunit protein uL18

1

3

High-throughput

0.536

High

161634

NUMB
Protein numb homolog

1

10

High-throughput

0.536

High

161635

MRE11
Double-strand break repair protein MRE11

1

1

High-throughput

0.536

High

161639

CLH2
Clathrin heavy chain 2

1

9

High-throughput

0.536

High

161640

SC24C
Protein transport protein Sec24C

1

2

High-throughput

0.536

High

161641

SEC13
Protein SEC13 homolog

1

7

High-throughput

0.536

High

161644

AP2B1
AP-2 complex subunit beta

1

17

High-throughput

0.536

High

161645

RACK1
Small ribosomal subunit protein RACK1

1

10

High-throughput

0.536

High

161646

DAB2
Disabled homolog 2

1

10

High-throughput

0.536

High

161653

PICAL
Phosphatidylinositol-binding clathrin assembly protein

1

19

High-throughput

0.536

High

161658

GOGB1
Golgin subfamily B member 1

1

14

High-throughput

0.536

High

161661

DREB
Drebrin

1

6

High-throughput

0.536

High

161669

EFMT2
EEF1A lysine methyltransferase 2

1

2

High-throughput

0.536

High

161671

FA83B
Protein FAM83B

1

1

High-throughput

0.536

High

161672

CE162
Centrosomal protein of 162 kDa

1

18

High-throughput

0.536

High

161677

FA83H
Protein FAM83H

1

1

High-throughput

0.536

High

161687

SYNPO
Synaptopodin

1

2

High-throughput

0.536

High

161692

DEN1A
DENN domain-containing protein 1A

1

2

High-throughput

0.536

High

161694

STON2
Stonin-2

1

7

High-throughput

0.536

High

161697

EFMT3
EEF1A lysine methyltransferase 3

1

4

High-throughput

0.536

High

161698

AP2M1
AP-2 complex subunit mu

1

7

High-throughput

0.536

High

161710

UBXN6
UBX domain-containing protein 6

1

1

High-throughput

0.536

High

161715

ZN106
Zinc finger protein 106

1

12

High-throughput

0.536

High

161719

PAAT
ATPase PAAT

1

3

High-throughput

0.536

High

161723

GTSE1
G2 and S phase-expressed protein 1

1

2

High-throughput

0.536

High

161727

S53A1
Solute carrier family 53 member 1

1

1

High-throughput

0.536

High

161729

LIMA1
LIM domain and actin-binding protein 1

1

7

High-throughput

0.536

High

161734

BAG5
BAG family molecular chaperone regulator 5

1

3

Small-scale

0.536

High

161737

MYO6
Unconventional myosin-VI

1

9

High-throughput

0.536

High

161743

KIF3A
Kinesin-like protein KIF3A

1

5

High-throughput

0.536

High

161589

SERA
D-3-phosphoglycerate dehydrogenase

1

0

High-throughput

0.513

High

161632

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.513

High

161675

NIPA3
Magnesium transporter NIPA3

1

0

High-throughput

0.513

High

161682

MISP
Mitotic interactor and substrate of PLK1

1

0

High-throughput

0.513

High

161683

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

161707

CHM4A
Charged multivesicular body protein 4a

1

0

High-throughput

0.513

High

161718

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

0

High-throughput

0.513

High

161730

SRP68
Signal recognition particle subunit SRP68

1

0

High-throughput

0.513

High

161746

MB212
Protein mab-21-like 2

1

0

High-throughput

0.513

High

161610

A4
Amyloid-beta precursor protein

1

3

High-throughput

0.501

High

161618

CBPM
Carboxypeptidase M

1

2

High-throughput

0.489

High

161637

PLXA3
Plexin-A3

1

4

High-throughput

0.489

High

161703

NPAS1
Neuronal PAS domain-containing protein 1

1

3

High-throughput

0.489

High

161714

PUS7L
Pseudouridylate synthase PUS7L

1

1

High-throughput

0.489

High

161590

TGON2
Trans-Golgi network integral membrane protein 2

1

6

High-throughput

0.479

High

161591

STX6
Syntaxin-6

1

2

High-throughput

0.479

High

161597

PEX14
Peroxisomal membrane protein PEX14

1

1

High-throughput

0.479

High

161599

CBPD
Carboxypeptidase D

1

2

High-throughput

0.479

High

161609

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

1

High-throughput

0.479

High

161617

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

2

High-throughput

0.479

High

161657

EPN4
Clathrin interactor 1

1

7

High-throughput

0.479

High

161659

CCDC6
Coiled-coil domain-containing protein 6

1

12

High-throughput

0.479

High

161664

CL16A
Protein CLEC16A

1

1

High-throughput

0.479

High

161668

PAR10
Protein mono-ADP-ribosyltransferase PARP10

1

8

High-throughput

0.479

High

161676

SYNE3
Nesprin-3

1

18

High-throughput

0.479

High

161679

ATG9A
Autophagy-related protein 9A

1

1

High-throughput

0.479

High

161681

NAA40
N-alpha-acetyltransferase 40

1

2

High-throughput

0.479

High

161685

RHG18
Rho GTPase-activating protein 18

1

7

High-throughput

0.479

High

161693

SMAP2
Stromal membrane-associated protein 2

1

3

High-throughput

0.479

High

161695

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

4

High-throughput

0.479

High

161696

ESR2
Estrogen receptor beta

1

12

High-throughput

0.479

High

161709

WDR11
WD repeat-containing protein 11

1

1

High-throughput

0.479

High

161712

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

3

High-throughput

0.479

High

161713

WWTR1
WW domain-containing transcription regulator protein 1

1

13

High-throughput

0.479

High

161725

RN181
E3 ubiquitin-protein ligase RNF181

1

4

High-throughput

0.479

High

161728

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

161732

ANC2
Anaphase-promoting complex subunit 2

1

9

High-throughput

0.479

High

161745

HYOU1
Hypoxia up-regulated protein 1

1

10

High-throughput

0.479

High

161586

SCAM1
Secretory carrier-associated membrane protein 1

1

0

High-throughput

0.458

High

161742

MED16
Mediator of RNA polymerase II transcription subunit 16

1

0

High-throughput

0.458

High

161615

ANDR
Androgen receptor

1

12

Small-scale

0.457

High

92561

E9PK67
Poly [ADP-ribose] polymerase

1

11

High-throughput

0.445

High

108854

H0YEF7
Phosphatidylinositol binding clathrin assembly protein

1

3

High-throughput

0.445

High

161649

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

1

High-throughput

0.445

High

161711

ZDHC5
Palmitoyltransferase ZDHHC5

1

3

High-throughput

0.445

High

161741

ITM2B
Integral membrane protein 2B

1

4

High-throughput

0.445

High

161620

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.437

High

161626

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.437

High

161628

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

161673

LTOR1
Ragulator complex protein LAMTOR1

1

1

High-throughput

0.437

High

161680

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

8

High-throughput

0.437

High

161702

GPX7
Glutathione peroxidase 7

2

0

High-throughput

0.328

High

161588

COPT1
High affinity copper uptake protein 1

1

0

High-throughput

0.279

Low

161667

EDRF1
Erythroid differentiation-related factor 1

1

0

High-throughput

0.279

Low

132369

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

0

High-throughput

0.249

Low

161747

ICOS
Inducible T-cell costimulator

1

0

Small-scale

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024