HitPredict

Interactor 1: LIS1 (P43034)
Platelet-activating factor acetylhydrolase IB subunit beta (Lissencephaly-1 protein) (LIS-1) (PAF acetylhydrolase 45 kDa subunit) (PAF-AH 45 kDa subunit) (PAF-AH alpha) (PAFAH alpha)
Gene: PAFAH1B1

Interactor 2: PA1B3 (Q15102)
Platelet-activating factor acetylhydrolase IB subunit alpha1 (EC 3.1.1.47) (PAF acetylhydrolase 29 kDa subunit) (PAF-AH 29 kDa subunit) (PAF-AH subunit gamma) (PAFAH subunit gamma)
Gene: PAFAH1B3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.924

Property	Details
Experiments	26186194, 28514442, 10727864, 33961781, 19622634
Identification Methods	affinity chromatography technology, pull down, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Lipase_GDSL_2~WD40
Common GO terms	GO:0005829 - cytosol GO:0008247 - 1-alkyl-2-acetylglycerophosphocholine esterase complex GO:0016042 - lipid catabolic process GO:0046982 - protein heterodimerization activity
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1 410 Hs			1 231
+	Mm
		925839 LIS1_MOUSE (1-410): 7.14e-137: 399: 99.76		PA1B3_MOUSE (1-230): 6.28e-146: 407: 96.10
+	Hs
		792971 LIS1_HUMAN (1-410): 7.96e-137: 399: 100.00		PA1B2_HUMAN (3-218): 2.32e-136: 383: 65.28