HitPredict

Interactor 1: SMD3 (P43321)
Small nuclear ribonucleoprotein Sm D3 (Sm-D3) (snRNP core protein D3)
Gene: SMD3

Interactor 2: SYF1 (Q04048)
Pre-mRNA-splicing factor SYF1 (PRP19-associated complex protein 90) (Synthetic lethal with CDC40 protein 1)
Gene: SYF1

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	16554755, 37968396
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0005634 - nucleus GO:0005829 - cytosol GO:0071004 - U2-type prespliceosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 101 Sc			1 859
+	Hs
		912738 SMD3_HUMAN (3-100): 3.04e-35: 118: 42.86		SYF1_HUMAN (30-845): 1.94e-154: 476: 21.48
+	Hs
		911970 RUXF_HUMAN (7-73): 2.92e-27: 96.9: 26.87		SYF1_HUMAN (30-845): 1.94e-154: 476: 21.48
+	Hs
		1063317 LSM4_HUMAN (6-89): 6.88e-35: 118: 35.29		SART3_HUMAN (398-838): 1.46e-44: 175: 13.31
+	Hs
		912638 SMD3_HUMAN (3-100): 3.04e-35: 118: 42.86		SART3_HUMAN (398-838): 1.46e-44: 175: 13.31
+	Hs
		1063313 LSM2_HUMAN (9-90): 5.65e-30: 104: 20.24		SART3_HUMAN (398-838): 1.46e-44: 175: 13.31
+	Hs
		911838 RUXF_HUMAN (7-73): 2.92e-27: 96.9: 26.87		SART3_HUMAN (398-838): 1.46e-44: 175: 13.31
+	Hs
		300104 SMD3_HUMAN (3-100): 3.04e-35: 118: 42.86		PRP6_HUMAN (459-856): 1.36e-23: 109: 12.94
+	Hs
		300299 LSM4_HUMAN (6-89): 6.88e-35: 118: 35.29		PRP6_HUMAN (459-856): 1.36e-23: 109: 12.94
+	Sc
		586416 SMD3_YEAST (1-101): 1.39e-34: 115: 100.00		PRP6_YEAST (157-799): 5.81e-22: 103: 12.19
+	Hs
		300294 LSM2_HUMAN (9-90): 5.65e-30: 104: 20.24		PRP6_HUMAN (459-856): 1.36e-23: 109: 12.94
+	Hs
		300099 RUXF_HUMAN (7-73): 2.92e-27: 96.9: 26.87		PRP6_HUMAN (459-856): 1.36e-23: 109: 12.94
+	Sp
		1015547 SMD3_SCHPO (4-101): 1.27e-32: 110: 51.02		PRP1_SCHPO (202-841): 1.62e-17: 89.7: 8.50
+	Sc
		586396 LSM2_YEAST (9-90): 3.45e-24: 89.6: 17.86		PRP6_YEAST (157-799): 5.81e-22: 103: 12.19
+	Sc
		586409 LSM4_YEAST (6-101): 5.39e-23: 88.8: 23.36		PRP6_YEAST (157-799): 5.81e-22: 103: 12.19
+	Sp
		193907 SMD1_SCHPO (7-96): 1.57e-28: 101: 24.44		PRP1_SCHPO (202-841): 1.62e-17: 89.7: 8.50
+	Sc
		795434 SMD3_YEAST (1-101): 1.39e-34: 115: 100.00		CLF1_YEAST (4-377): 2.18e-12: 72.7: 11.71
+	Hs
		1318167 LSM2_HUMAN (9-90): 5.65e-30: 104: 20.24		CRNL1_HUMAN (8-269): 3.6e-11: 69.3: 18.80
+	Hs
		911872 RUXF_HUMAN (7-73): 2.92e-27: 96.9: 26.87		CTR9_HUMAN (302-847): 4.99e-12: 71.9: 9.92
+	Hs
		911958 RUXF_HUMAN (7-73): 2.92e-27: 96.9: 26.87		CRNL1_HUMAN (8-269): 3.6e-11: 69.3: 18.80
+	Sc
		746365 LSM2_YEAST (9-90): 3.45e-24: 89.6: 17.86		CLF1_YEAST (4-377): 2.18e-12: 72.7: 11.71