Protein: XPP3
Xaa-Pro aminopeptidase 3 (X-Pro aminopeptidase 3) (EC 3.4.11.9) (Aminopeptidase P3) (APP3)

Gene: XPP3, XPNPEP3
Organism: Homo sapiens
Interactions: 81
UniProt ID: Q9NQH7

Gene Ontology (top 5):
GO:0003094 - glomerular filtration
GO:0004177 - aminopeptidase activity
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

475013

VIME
Vimentin

3

1

High-throughput

0.675

High

564413

CFTR
Cystic fibrosis transmembrane conductance regulator

3

1

High-throughput

0.662

High

1447122

XPP3
Xaa-Pro aminopeptidase 3

1

4

High-throughput

0.618

High

1366132

DYRK2
Dual specificity tyrosine-phosphorylation-regulated kinase 2

2

1

Small-scale

0.611

High

541703

FGFR1
Fibroblast growth factor receptor 1

2

4

High-throughput

0.601

High

630365

TNR1B
Tumor necrosis factor receptor superfamily member 1B

3

1

High-throughput

0.593

High

872776

SOX2
Transcription factor SOX-2

2

6

High-throughput

0.571

High

1162574

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

0

High-throughput

0.559

High

414680

P53
Cellular tumor antigen p53

1

1

High-throughput

0.536

High

570605

GFAP
Glial fibrillary acidic protein

1

1

High-throughput

0.536

High

876647

NEST
Nestin

1

3

High-throughput

0.536

High

1034196

ROR1
Inactive tyrosine-protein kinase transmembrane receptor ROR1

1

7

High-throughput

0.536

High

1114381

CUL3
Cullin-3

1

7

High-throughput

0.536

High

1337752

DAAF1
Dynein axonemal assembly factor 1

1

2

High-throughput

0.536

High

1385739

BIRC7
Baculoviral IAP repeat-containing protein 7

1

1

High-throughput

0.536

High

1404985

GA2L1
GAS2-like protein 1

1

1

High-throughput

0.536

High

650975

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

2

High-throughput

0.515

High

1181548

RA1L2
Heterogeneous nuclear ribonucleoprotein A1-like 2

1

2

High-throughput

0.515

High

175222

SC16A
Protein transport protein Sec16A

1

0

High-throughput

0.513

High

284418

CLN5
Bis(monoacylglycero)phosphate synthase CLN5

1

0

High-throughput

0.513

High

965902

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

0

High-throughput

0.513

High

1290164

THOC4
THO complex subunit 4

1

0

High-throughput

0.513

High

1347874

RIN3
Ras and Rab interactor 3

1

0

High-throughput

0.513

High

1370910

GCDH
Glutaryl-CoA dehydrogenase, mitochondrial

1

0

High-throughput

0.513

High

1399140

CF418
Cilia- and flagella-associated protein 418

1

0

High-throughput

0.513

High

1410192

TCF25
Ribosome quality control complex subunit TCF25

1

0

High-throughput

0.513

High

1394124

KAZD1
Kazal-type serine protease inhibitor domain-containing protein 1

1

6

High-throughput

0.489

High

223355

PRC1
Protein regulator of cytokinesis 1

1

1

High-throughput

0.479

High

227678

SPOP
Speckle-type POZ protein

1

1

High-throughput

0.479

High

243022

PRKN
E3 ubiquitin-protein ligase parkin

1

5

High-throughput

0.479

High

272479

OBSL1
Obscurin-like protein 1

1

3

High-throughput

0.479

High

326058

UBR5
E3 ubiquitin-protein ligase UBR5

1

2

Small-scale

0.479

High

331345

KI20A
Kinesin-like protein KIF20A

1

5

High-throughput

0.479

High

347943

BAG3
BAG family molecular chaperone regulator 3

1

1

High-throughput

0.479

High

404453

GCR
Glucocorticoid receptor

1

3

Small-scale

0.479

High

575205

IDE
Insulin-degrading enzyme

1

3

High-throughput

0.479

High

905176

MECP2
Methyl-CpG-binding protein 2

1

1

High-throughput

0.479

High

1035930

KIF23
Kinesin-like protein KIF23

1

3

High-throughput

0.479

High

1255674

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.479

High

1364609

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

1385874

CHM4C
Charged multivesicular body protein 4c

1

2

High-throughput

0.479

High

1391786

AURKB
Aurora kinase B

1

2

High-throughput

0.479

High

1447123

ANLN
Anillin

1

1

High-throughput

0.479

High

1447124

WHRN
Whirlin

1

1

High-throughput

0.479

High

1447125

PAK5
Serine/threonine-protein kinase PAK 5

1

2

High-throughput

0.479

High

1447126

FBW1A
F-box/WD repeat-containing protein 1A

1

5

High-throughput

0.479

High

1447127

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

1

1

Small-scale

0.479

High

361361

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.458

High

593700

BGAL
Beta-galactosidase

1

0

High-throughput

0.458

High

1030040

RELB
Transcription factor RelB

1

0

High-throughput

0.458

High

1058302

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1092661

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

0

High-throughput

0.458

High

1357853

AFG1L
AFG1-like ATPase

1

0

High-throughput

0.458

High

1359198

MAIP1
m-AAA protease-interacting protein 1, mitochondrial

1

0

High-throughput

0.458

High

1389289

RM53
Large ribosomal subunit protein mL53

1

0

High-throughput

0.458

High

1407896

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.458

High

1410501

RT63
Large ribosomal subunit protein mL63

1

0

High-throughput

0.458

High

1421066

ZY11B
Protein zyg-11 homolog B

1

0

High-throughput

0.458

High

1436167

NT5D2
5'-nucleotidase domain-containing protein 2

1

0

High-throughput

0.458

High

1447128

PDIP2
Polymerase delta-interacting protein 2

1

0

High-throughput

0.458

High

1447129

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

0

High-throughput

0.458

High

765914

BMI1
Polycomb complex protein BMI-1

1

3

High-throughput

0.445

High

1227517

A16L1
Autophagy-related protein 16-1

1

9

High-throughput

0.445

High

1428372

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

3

High-throughput

0.445

High

653589

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.426

High

1432805

GCP60
Golgi resident protein GCP60

1

0

Small-scale

0.426

High

430397

JUN
Transcription factor Jun

1

2

High-throughput

0.407

High

1335738

MOT11
Monocarboxylate transporter 11

1

1

High-throughput

0.407

High

518443

PYY
Peptide YY

1

0

High-throughput

0.279

Low

531195

CMGA
Chromogranin-A

1

0

High-throughput

0.279

Low

1154352

CYTM
Cystatin-M

1

0

High-throughput

0.279

Low

1231984

IL31
Interleukin-31

1

0

High-throughput

0.279

Low

1308008

RELL1
RELT-like protein 1

1

0

High-throughput

0.279

Low

1322571

LSME2
Leucine-rich single-pass membrane protein 2

1

0

High-throughput

0.279

Low

583343

FOLR1
Folate receptor alpha

1

0

High-throughput

0.249

Low

1241806

PRP8
Pre-mRNA-processing-splicing factor 8

1

0

High-throughput

0.249

Low

219455

S26A4
Pendrin

1

0

High-throughput

0.232

Low

337141

NPT2B
Sodium-dependent phosphate transport protein 2B

1

0

High-throughput

0.232

Low

1105249

S39A6
Zinc transporter ZIP6

1

0

High-throughput

0.232

Low

1402426

HPLN3
Hyaluronan and proteoglycan link protein 3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025