HitPredict

Interactor 1: ZAP70 (P43403)
Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-chain associated protein) (Syk-related tyrosine kinase)
Gene: ZAP70

Interactor 2: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.755

Property	Details
Experiments	10419455, 16339550
Identification Methods	pull down
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1, SH2~SH2, SH2~SH3_1, SH2~SH3_2
Common GO terms	GO:0001784 - phosphotyrosine residue binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 619 Hs			1 304
+	Mm
		796508 ZAP70_MOUSE (1-619): 0: 633: 92.90		CRK_MOUSE (1-304): 5.53e-68: 215: 99.67
+	Mm
		796493 ZAP70_MOUSE (1-619): 0: 633: 92.90		CRKL_MOUSE (2-302): 6.92e-57: 187: 47.10
+	Hs
		548655 ZAP70_HUMAN (1-619): 0: 641: 100.00		VAV_HUMAN (11-189): 6.6e-47: 170: 28.21
+	Mm
		654974 ZAP70_MOUSE (1-619): 0: 633: 92.90		VAV_MOUSE (11-189): 7.04e-46: 167: 27.23
+	Hs
		580955 ZAP70_HUMAN (1-619): 0: 641: 100.00		PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39
+	Hs
		796465 ZAP70_HUMAN (1-619): 0: 641: 100.00		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		796524 KSYK_HUMAN (1-600): 0: 554: 53.58		CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07
+	Mm
		796503 ZAP70_MOUSE (1-619): 0: 633: 92.90		GRB2_MOUSE (135-297): 1.43e-25: 103: 15.67
+	Hs
		548656 KSYK_HUMAN (1-600): 0: 554: 53.58		VAV_HUMAN (11-189): 6.6e-47: 170: 28.21
+	Hs
		275178 KSYK_HUMAN (1-600): 0: 554: 53.58		GRAP2_HUMAN (1-296): 5.17e-33: 125: 17.17
+	Hs
		796531 KSYK_HUMAN (1-600): 0: 554: 53.58		VAV2_HUMAN (2-191): 3.44e-29: 119: 19.74
+	Hs
		580956 KSYK_HUMAN (1-600): 0: 554: 53.58		PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39
+	Hs
		562633 KSYK_HUMAN (1-600): 0: 554: 53.58		PLCG2_HUMAN (1-301): 1.03e-25: 109: 15.89
+	Hs
		796538 KSYK_HUMAN (1-600): 0: 554: 53.58		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		665168 EPHA2_HUMAN (20-614): 3.34e-152: 465: 22.71		CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07
+	Hs
		411580 LCK_HUMAN (58-608): 4.13e-159: 467: 26.79		VAV_HUMAN (11-189): 6.6e-47: 170: 28.21
+	Hs
		557633 KSYK_HUMAN (1-600): 0: 554: 53.58		NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00
+	Hs
		665200 EPHA2_HUMAN (20-614): 3.34e-152: 465: 22.71		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		208996 EPHA2_HUMAN (20-614): 3.34e-152: 465: 22.71		NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00
+	Hs
		411817 LCK_HUMAN (58-608): 4.13e-159: 467: 26.79		SH3K1_HUMAN (114-192): 4.08e-10: 62.5: 22.22