HitPredict

Interactor 1: KSYK (P43405)
Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase) (p72-Syk)
Gene: SYK

Interactor 2: GAB1 (Q13480)
GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1)
Gene: GAB1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.692

Property	Details
Experiments	24728074
Identification Methods	pull down, fluorescence polarization spectroscopy
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr
Common GO terms	GO:0001525 - angiogenesis GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 635 Hs			1 694
+	Hs
		796489 ZAP70_HUMAN (6-635): 0: 535: 53.57		GAB2_HUMAN (3-691): 2.24e-153: 461: 39.01
+	Hs
		872436 EPHA5_HUMAN (171-632): 5.04e-115: 370: 25.42		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		1035376 NTRK2_HUMAN (158-631): 7.36e-116: 366: 24.27		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		507983 FGFR1_HUMAN (179-635): 7.43e-116: 366: 26.24		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Mm
		546325 NTRK2_MOUSE (164-631): 6.74e-116: 366: 23.96		GAB1_MOUSE (1-694): 0: 544: 89.93
+	Hs
		665234 EPHA2_HUMAN (242-629): 6.67e-111: 357: 28.83		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		872642 EPHA4_HUMAN (329-626): 1.47e-105: 343: 34.54		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		996561 ITK_HUMAN (136-626): 3.44e-108: 341: 27.60		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		411709 LCK_HUMAN (5-201): 3.03e-71: 240: 23.29		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		522965 SRC_HUMAN (4-371): 2.15e-70: 239: 15.46		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Mm
		403466 SRC_MOUSE (4-371): 4.55e-71: 241: 15.46		GAB1_MOUSE (1-694): 0: 544: 89.93
+	Hs
		508062 FGFR1_HUMAN (179-635): 7.43e-116: 366: 26.24		PKHA7_HUMAN (5-485): 5.86e-74: 260: 12.07
+	Hs
		872491 EPHA5_HUMAN (171-632): 5.04e-115: 370: 25.42		PKHA5_HUMAN (5-476): 6.15e-67: 240: 13.00
+	Hs
		508203 FGFR1_HUMAN (179-635): 7.43e-116: 366: 26.24		PKHA5_HUMAN (5-476): 6.15e-67: 240: 13.00
+	Hs
		872492 EPHA5_HUMAN (171-632): 5.04e-115: 370: 25.42		PKHA1_HUMAN (6-156): 1.25e-32: 132: 25.49
+	Hs
		411764 LCK_HUMAN (5-201): 3.03e-71: 240: 23.29		PKHA7_HUMAN (5-485): 5.86e-74: 260: 12.07
+	Hs
		508205 FGFR1_HUMAN (179-635): 7.43e-116: 366: 26.24		PKHA1_HUMAN (6-156): 1.25e-32: 132: 25.49
+	Hs
		411861 LCK_HUMAN (5-201): 3.03e-71: 240: 23.29		PKHA5_HUMAN (5-476): 6.15e-67: 240: 13.00
+	Hs
		872712 EPHA4_HUMAN (329-626): 1.47e-105: 343: 34.54		PKHA1_HUMAN (6-156): 1.25e-32: 132: 25.49
+	Hs
		411897 LCK_HUMAN (5-201): 3.03e-71: 240: 23.29		PKHA6_HUMAN (5-495): 5.54e-58: 214: 13.33