Protein: OTUD1
OTU domain-containing protein 1 (EC 3.4.19.12) (DUBA-7)

Gene: OTUD1
Organism: Homo sapiens
Interactions: 174
UniProt ID: Q5VV17

Gene Ontology (top 5):
GO:0004843 - cysteine-type deubiquitinase activity
GO:0006508 - proteolysis
GO:0070536 - protein K63-linked deubiquitination

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

931671

RD23B
UV excision repair protein RAD23 homolog B

2

7

Small-scale

0.705

High

508117

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

11

Small-scale

0.696

High

1125347

FLNC
Filamin-C

4

13

Small-scale

0.626

High

931542

RD23A
UV excision repair protein RAD23 homolog A

1

5

High-throughput

0.618

High

1218334

OTUD1
OTU domain-containing protein 1

1

9

Small-scale

0.618

High

348550

AIFM1
Apoptosis-inducing factor 1, mitochondrial

3

1

Small-scale

0.612

High

278102

FLNB
Filamin-B

3

11

Small-scale

0.599

High

637563

FLNA
Filamin-A

3

11

Small-scale

0.599

High

177691

SMAD7
Mothers against decapentaplegic homolog 7

2

1

Small-scale

0.579

High

1109609

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

2

7

Small-scale

0.575

High

856732

BAG6
Large proline-rich protein BAG6

1

6

Small-scale

0.553

High

967460

RS7
Small ribosomal subunit protein eS7

1

2

High-throughput

0.553

High

987380

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

3

Small-scale

0.553

High

907466

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

1

High-throughput

0.536

High

842785

CDN2A
Cyclin-dependent kinase inhibitor 2A

2

5

Small-scale

0.533

High

992794

RACK1
Small ribosomal subunit protein RACK1

2

4

Small-scale

0.533

High

1129146

IRF3
Interferon regulatory factor 3

2

4

Small-scale

0.533

High

862210

YAP1
Transcriptional coactivator YAP1

1

4

Small-scale

0.528

High

1096980

PRDX4
Peroxiredoxin-4

1

1

Small-scale

0.528

High

1208918

DCA10
DDB1- and CUL4-associated factor 10

1

3

Small-scale

0.528

High

728287

AKT1
RAC-alpha serine/threonine-protein kinase

1

4

Small-scale

0.512

High

1218355

CARD9
Caspase recruitment domain-containing protein 9

1

2

Small-scale

0.512

High

85993

IGLL5
Immunoglobulin lambda-like polypeptide 5

1

1

High-throughput

0.437

High

1057174

PRDX1
Peroxiredoxin-1

1

1

High-throughput

0.437

High

1058073

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

1

Small-scale

0.437

High

123119

DX39A
ATP-dependent RNA helicase DDX39A

1

3

High-throughput

0.437

High

160525

IRS4
Insulin receptor substrate 4

1

1

High-throughput

0.437

High

170190

AURKA
Aurora kinase A

1

10

Small-scale

0.437

High

172921

XPO1
Exportin-1

1

6

High-throughput

0.437

High

209582

SERA
D-3-phosphoglycerate dehydrogenase

1

4

High-throughput

0.437

High

214440

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

1

4

Small-scale

0.437

High

250264

VINEX
Vinexin

1

12

High-throughput

0.437

High

286217

CSDE1
Cold shock domain-containing protein E1

1

2

High-throughput

0.437

High

301083

RL1D1
Ribosomal L1 domain-containing protein 1

1

3

High-throughput

0.437

High

344948

WIZ
Protein Wiz

1

1

High-throughput

0.437

High

347096

BAG2
BAG family molecular chaperone regulator 2

1

2

High-throughput

0.437

High

350037

SNAI1
Zinc finger protein SNAI1

1

2

Small-scale

0.437

High

414002

P53
Cellular tumor antigen p53

1

2

Small-scale

0.437

High

415633

HSPB1
Heat shock protein beta-1

1

3

High-throughput

0.437

High

426281

IF2A
Eukaryotic translation initiation factor 2 subunit 1

1

2

High-throughput

0.437

High

443402

CDK1
Cyclin-dependent kinase 1

1

1

High-throughput

0.437

High

443828

ATPB
ATP synthase F(1) complex subunit beta, mitochondrial

1

2

High-throughput

0.437

High

468483

HS90B
Heat shock protein HSP 90-beta

1

2

High-throughput

0.437

High

476713

RSSA
Small ribosomal subunit protein uS2

1

2

High-throughput

0.437

High

547623

C1TC
C-1-tetrahydrofolate synthase, cytoplasmic

1

1

High-throughput

0.437

High

549610

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

1

High-throughput

0.437

High

550322

PABP1
Polyadenylate-binding protein 1

1

9

Small-scale

0.437

High

558195

XRCC6
X-ray repair cross-complementing protein 6

1

1

High-throughput

0.437

High

573132

KPYM
Pyruvate kinase PKM

1

1

High-throughput

0.437

High

599801

YBOX3
Y-box-binding protein 3

1

4

High-throughput

0.437

High

610707

TCPA
T-complex protein 1 subunit alpha

1

2

High-throughput

0.437

High

615825

RL17
Large ribosomal subunit protein uL22

1

1

High-throughput

0.437

High

669920

MCM3
DNA replication licensing factor MCM3

1

4

High-throughput

0.437

High

684270

DDX6
Probable ATP-dependent RNA helicase DDX6

1

5

High-throughput

0.437

High

687684

SYTC
Threonine--tRNA ligase 1, cytoplasmic

1

1

High-throughput

0.437

High

687821

SYVC
Valine--tRNA ligase

1

2

High-throughput

0.437

High

688029

EF1G
Elongation factor 1-gamma

1

2

High-throughput

0.437

High

691108

1433T
14-3-3 protein theta

1

15

High-throughput

0.437

High

693787

RL10
Large ribosomal subunit protein uL16

1

1

High-throughput

0.437

High

697560

PYR1
Multifunctional protein CAD

1

1

High-throughput

0.437

High

717851

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

1

High-throughput

0.437

High

719443

PPIF
Peptidyl-prolyl cis-trans isomerase F, mitochondrial

1

2

High-throughput

0.437

High

727840

DNJA1
DnaJ homolog subfamily A member 1

1

4

High-throughput

0.437

High

728597

AKT2
RAC-beta serine/threonine-protein kinase

1

4

Small-scale

0.437

High

755955

MCM5
DNA replication licensing factor MCM5

1

3

High-throughput

0.437

High

756236

MCM7
DNA replication licensing factor MCM7

1

3

High-throughput

0.437

High

761707

HSP74
Heat shock 70 kDa protein 4

1

2

High-throughput

0.437

High

764827

CTNB1
Catenin beta-1

1

1

Small-scale

0.437

High

778704

PRS7
26S proteasome regulatory subunit 7

1

2

High-throughput

0.437

High

824187

RL13A
Large ribosomal subunit protein uL13

1

1

High-throughput

0.437

High

852773

VDAC2
Non-selective voltage-gated ion channel VDAC2

1

1

High-throughput

0.437

High

876008

TCPE
T-complex protein 1 subunit epsilon

1

2

High-throughput

0.437

High

881968

TCPG
T-complex protein 1 subunit gamma

1

2

High-throughput

0.437

High

890337

NU153
Nuclear pore complex protein Nup153

1

10

High-throughput

0.437

High

899078

TCPQ
T-complex protein 1 subunit theta

1

3

High-throughput

0.437

High

899964

FXR1
RNA-binding protein FXR1

1

8

High-throughput

0.437

High

916279

TXTP
Tricarboxylate transport protein, mitochondrial

1

1

High-throughput

0.437

High

953911

IF4A1
Eukaryotic initiation factor 4A-I

1

4

High-throughput

0.437

High

968952

PRS8
26S proteasome regulatory subunit 8

1

2

High-throughput

0.437

High

971626

1433E
14-3-3 protein epsilon

1

2

High-throughput

0.437

High

977519

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

2

High-throughput

0.437

High

981856

RL23
Large ribosomal subunit protein uL14

1

3

High-throughput

0.437

High

982699

RS24
Small ribosomal subunit protein eS24

1

1

High-throughput

0.437

High

986480

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

2

High-throughput

0.437

High

991043

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

1

High-throughput

0.437

High

993426

ACTH
Actin, gamma-enteric smooth muscle

1

2

High-throughput

0.437

High

997377

TBB4B
Tubulin beta-4B chain

1

2

High-throughput

0.437

High

1014533

SMAD3
Mothers against decapentaplegic homolog 3

1

1

Small-scale

0.437

High

1047026

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

1

5

High-throughput

0.437

High

1047574

NOTC2
Neurogenic locus notch homolog protein 2

1

3

Small-scale

0.437

High

1056786

FMR1
Fragile X messenger ribonucleoprotein 1

1

8

High-throughput

0.437

High

1096040

TADBP
TAR DNA-binding protein 43

1

11

High-throughput

0.437

High

1096565

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

1

High-throughput

0.437

High

1113352

CUL3
Cullin-3

1

6

Small-scale

0.437

High

1114882

CUL4A
Cullin-4A

1

6

Small-scale

0.437

High

1116422

FHL1
Four and a half LIM domains protein 1

1

7

High-throughput

0.437

High

1121796

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

4

High-throughput

0.437

High

1125128

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

7

High-throughput

0.437

High

1126427

CAPR1
Caprin-1

1

4

High-throughput

0.437

High

1141677

EEA1
Early endosome antigen 1

1

6

High-throughput

0.437

High

1145808

IRF4
Interferon regulatory factor 4

1

4

Small-scale

0.437

High

1146915

PCBP2
Poly(rC)-binding protein 2

1

6

Small-scale

0.437

High

1148896

SC23A
Protein transport protein Sec23A

1

1

High-throughput

0.437

High

1148984

SC23B
Protein transport protein Sec23B

1

1

High-throughput

0.437

High

1206465

PRC2B
Protein PRRC2B

1

12

High-throughput

0.437

High

1218336

H3C
Histone H3.3C

1

5

High-throughput

0.437

High

1218338

SND1
Staphylococcal nuclease domain-containing protein 1

1

1

High-throughput

0.437

High

1218339

DHX30
ATP-dependent RNA helicase DHX30

1

5

High-throughput

0.437

High

1218341

ZN598
E3 ubiquitin-protein ligase ZNF598

1

3

High-throughput

0.437

High

1218342

PGAM4
Probable phosphoglycerate mutase 4

1

3

Small-scale

0.437

High

1218343

AHI1
Jouberin

1

5

Small-scale

0.437

High

1218344

CCAR2
Cell cycle and apoptosis regulator protein 2

1

2

Small-scale

0.437

High

1218346

SMRC1
SWI/SNF complex subunit SMARCC1

1

6

Small-scale

0.437

High

1218347

FUBP2
Far upstream element-binding protein 2

1

10

High-throughput

0.437

High

1218348

IRF7
Interferon regulatory factor 7

1

4

Small-scale

0.437

High

1218350

FUBP3
Far upstream element-binding protein 3

1

10

High-throughput

0.437

High

1218351

CDC5L
Cell division cycle 5-like protein

1

1

High-throughput

0.437

High

1218352

ANM1
Protein arginine N-methyltransferase 1

1

3

High-throughput

0.437

High

1218354

YTHD1
YTH domain-containing family protein 1

1

8

High-throughput

0.437

High

1218357

BRD9
Bromodomain-containing protein 9

1

2

High-throughput

0.437

High

1218359

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

2

Small-scale

0.437

High

1218362

LANC2
LanC-like protein 2

1

1

High-throughput

0.437

High

1218363

ATD3A
ATPase family AAA domain-containing protein 3A

1

2

High-throughput

0.437

High

1218366

DIC
Mitochondrial dicarboxylate carrier

1

1

High-throughput

0.437

High

1218369

TNR6B
Trinucleotide repeat-containing gene 6B protein

1

6

Small-scale

0.437

High

1218370

AKT3
RAC-gamma serine/threonine-protein kinase

1

4

Small-scale

0.437

High

62028

A4D1J9
Similar to Filamin C

1

6

High-throughput

0.407

High

1121418

KEAP1
Kelch-like ECH-associated protein 1

3

0

Small-scale

0.339

High

210974

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

0

High-throughput

0.249

Low

219635

B2L11
Bcl-2-like protein 11

1

0

Small-scale

0.249

Low

333671

NDUAA
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

1

0

High-throughput

0.249

Low

378116

TNFA
Tumor necrosis factor

1

0

Small-scale

0.249

Low

417492

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.249

Low

467922

PFKAM
ATP-dependent 6-phosphofructokinase, muscle type

1

0

High-throughput

0.249

Low

539065

UMPS
Uridine 5'-monophosphate synthase

1

0

High-throughput

0.249

Low

552274

ADT3
ADP/ATP translocase 3

1

0

High-throughput

0.249

Low

646861

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

0

High-throughput

0.249

Low

724760

METK2
S-adenosylmethionine synthase isoform type-2

1

0

High-throughput

0.249

Low

837660

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.249

Low

841782

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.249

Low

855105

NOP2
28S rRNA

1

0

High-throughput

0.249

Low

869889

ATPO
ATP synthase peripheral stalk subunit OSCP, mitochondrial

1

0

High-throughput

0.249

Low

910937

IMA1
Importin subunit alpha-1

1

0

High-throughput

0.249

Low

912069

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

0

High-throughput

0.249

Low

939792

ATPK
ATP synthase F(0) complex subunit f, mitochondrial

1

0

High-throughput

0.249

Low

951203

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.249

Low

960760

RL15
Large ribosomal subunit protein eL15

1

0

High-throughput

0.249

Low

974765

SMD3
Small nuclear ribonucleoprotein Sm D3

1

0

High-throughput

0.249

Low

1005886

GTF2I
General transcription factor II-I

1

0

High-throughput

0.249

Low

1060268

MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1

1

0

Small-scale

0.249

Low

1066347

RBBP4
Histone-binding protein RBBP4

1

0

High-throughput

0.249

Low

1105309

SF3B2
Splicing factor 3B subunit 2

1

0

High-throughput

0.249

Low

1111040

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.249

Low

1134229

IMB1
Importin subunit beta-1

1

0

High-throughput

0.249

Low

1147613

TOM20
Mitochondrial import receptor subunit TOM20 homolog

1

0

Small-scale

0.249

Low

1157759

DDB1
DNA damage-binding protein 1

1

0

Small-scale

0.249

Low

1212510

CAF17
Iron-sulfur cluster assembly factor IBA57, mitochondrial

1

0

High-throughput

0.249

Low

1218335

DRS7B
Dehydrogenase/reductase SDR family member 7B

1

0

High-throughput

0.249

Low

1218337

PRP8
Pre-mRNA-processing-splicing factor 8

1

0

Small-scale

0.249

Low

1218340

PEG10
Retrotransposon-derived protein PEG10

1

0

High-throughput

0.249

Low

1218345

MIA40
Mitochondrial intermembrane space import and assembly protein 40

1

0

Small-scale

0.249

Low

1218349

PGAM5
Serine/threonine-protein phosphatase PGAM5, mitochondrial

1

0

Small-scale

0.249

Low

1218353

PDD2L
Programmed cell death protein 2-like

1

0

High-throughput

0.249

Low

1218356

GCP60
Golgi resident protein GCP60

1

0

High-throughput

0.249

Low

1218358

TM165
Putative divalent cation/proton antiporter TMEM165

1

0

Small-scale

0.249

Low

1218360

DBLOH
Diablo IAP-binding mitochondrial protein

1

0

Small-scale

0.249

Low

1218361

AAAS
Aladin

1

0

High-throughput

0.249

Low

1218364

CARF
CDKN2A-interacting protein

1

0

High-throughput

0.249

Low

1218365

TECR
Very-long-chain enoyl-CoA reductase

1

0

High-throughput

0.249

Low

1218367

IP6K2
Inositol hexakisphosphate kinase 2

1

0

High-throughput

0.249

Low

1218368

STML2
Stomatin-like protein 2, mitochondrial

1

0

High-throughput

0.249

Low

1218371

SYFA
Phenylalanine--tRNA ligase alpha subunit

1

0

High-throughput

0.249

Low

1218372

RTCB
RNA-splicing ligase RtcB homolog

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025