HitPredict

Interactor 1: RPN11 (P43588)
Ubiquitin carboxyl-terminal hydrolase RPN11 (EC 3.4.19.12) (26S proteasome regulatory subunit RPN11) (Protein MPR1)
Gene: RPN11

Interactor 2: DSK2 (P48510)
Ubiquitin domain-containing protein DSK2
Gene: DSK2

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	1.00	0.959

Property	Details
Experiments	20061387, 16284124, 26450923, 28525741, 18757749, 20170199, 21627799
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	JAB~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 306 Sc			1 373
+	Hs
		130813 PSDE_HUMAN (16-306): 2.53e-98: 293: 67.35		RD23A_HUMAN (1-370): 2.33e-57: 192: 16.92
+	Rn
		1117318 Q4V8E2_RAT (16-306): 2.53e-98: 293: 67.35		RD23B_RAT (3-369): 2.17e-52: 181: 14.38
+	Hs
		130814 PSDE_HUMAN (16-306): 2.53e-98: 293: 67.35		RD23B_HUMAN (3-369): 2.45e-50: 175: 13.70
+	Sc
		697094 RPN11_YEAST (1-306): 4.59e-91: 274: 100.00		RAD23_YEAST (2-370): 3.25e-51: 177: 15.25
+	Hs
		130790 PSDE_HUMAN (16-306): 2.53e-98: 293: 67.35		BAG6_HUMAN (2-313): 7.67e-32: 129: 20.74
+	Dm
		1358677 PSDE_DROME (1-306): 6.79e-103: 305: 64.29		Q9VWD9_DROME (79-367): 2.13e-21: 97.7: 18.86
+	Hs
		130838 PSDE_HUMAN (16-306): 2.53e-98: 293: 67.35		RL40_HUMAN (3-73): 2.22e-28: 109: 36.11
+	Hs
		131106 PSDE_HUMAN (16-306): 2.53e-98: 293: 67.35		UBQL1_HUMAN (73-370): 3.03e-20: 94.2: 17.61
+	Hs
		131100 PSDE_HUMAN (16-306): 2.53e-98: 293: 67.35		UBQL2_HUMAN (73-370): 4.05e-19: 90.7: 20.25
+	Hs
		131091 PSDE_HUMAN (16-306): 2.53e-98: 293: 67.35		UBQL4_HUMAN (74-370): 4.18e-18: 87.6: 13.64
+	Zm
		27878 B4FLQ8_MAIZE (1-305): 2.66e-100: 298: 63.84		A0A1D6JMS0_MAIZE (70-370): 4.66e-14: 75.3: 18.15
+	Sc
		697121 RPN8_YEAST (25-305): 6.68e-51: 172: 16.03		RAD23_YEAST (2-370): 3.25e-51: 177: 15.25
+	Hs
		1079562 CSN5_HUMAN (14-292): 7.24e-75: 234: 30.74		NEDD8_HUMAN (5-71): 1.4e-21: 89.7: 39.71
+	Hs
		124789 EIF3F_HUMAN (3-305): 7.75e-56: 186: 14.24		BAG6_HUMAN (2-313): 7.67e-32: 129: 20.74
+	Hs
		849167 PSMD7_HUMAN (23-149): 5.65e-31: 120: 24.06		RD23A_HUMAN (1-370): 2.33e-57: 192: 16.92
+	Hs
		176966 EIF3H_HUMAN (19-260): 4.97e-49: 168: 20.08		BAG6_HUMAN (2-313): 7.67e-32: 129: 20.74
+	Hs
		803427 BRCC3_HUMAN (28-180): 3.11e-42: 149: 24.73		BAG6_HUMAN (2-313): 7.67e-32: 129: 20.74
+	Hs
		124955 EIF3F_HUMAN (3-305): 7.75e-56: 186: 14.24		UBQL2_HUMAN (73-370): 4.05e-19: 90.7: 20.25
+	Zm
		46881 A0A3L6GBJ0_MAIZE (6-286): 9.29e-59: 194: 17.13		C0PFA7_MAIZE (73-370): 1.86e-16: 82.6: 16.13
+	Dm
		640796 PSMD7_DROME (23-305): 1.03e-43: 154: 15.57		Q9VWD9_DROME (79-367): 2.13e-21: 97.7: 18.86