Protein: MKAR
Very-long-chain 3-oxoacyl-CoA reductase (EC 1.1.1.330) (3-ketoacyl-CoA reductase) (3-ketoreductase) (KAR) (Microsomal beta-keto-reductase)

Gene: MKAR, IFA38
Organism: Saccharomyces cerevisiae S288C
Interactions: 178
UniProt ID: P38286

Gene Ontology (top 5):
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0030148 - sphingolipid biosynthetic process
GO:0030497 - fatty acid elongation
GO:0042761 - very long-chain fatty acid biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

748364

SC61A
Protein transport protein SEC61

2

3

High-throughput

0.614

High

797375

SSH1
Sec sixty-one protein homolog

2

3

High-throughput

0.614

High

726080

PMT2
Dolichyl-phosphate-mannose--protein mannosyltransferase 2

2

1

High-throughput

0.601

High

738583

EI2BE
Translation initiation factor eIF2B subunit epsilon

2

1

Small-scale

0.560

High

738631

EI2BB
Translation initiation factor eIF2B subunit beta

2

2

Small-scale

0.560

High

416696

CAN1
Arginine permease CAN1

1

7

High-throughput

0.541

High

448255

HIP1
Histidine permease

1

7

High-throughput

0.541

High

609272

CPT1
Cholinephosphotransferase 1

1

1

High-throughput

0.541

High

618865

GAP1
General amino-acid permease GAP1

1

7

High-throughput

0.541

High

645104

EPT1
Choline/ethanolaminephosphotransferase 1

1

1

High-throughput

0.541

High

671361

PHO84
Inorganic phosphate transporter PHO84

1

5

High-throughput

0.541

High

673290

ADP1
Probable ATP-dependent permease

1

3

High-throughput

0.541

High

673419

AGP1
General amino acid permease AGP1

1

7

High-throughput

0.541

High

703809

LAC1
Ceramide synthase LAC1

1

1

High-throughput

0.541

High

735332

ERG3
Delta(7)-sterol 5(6)-desaturase ERG3

1

2

High-throughput

0.541

High

735824

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

2

High-throughput

0.541

High

745328

EMP24
Endosomal protein P24B

1

7

High-throughput

0.541

High

751822

SGE1
Protein SGE1

1

8

High-throughput

0.541

High

754615

OSTB
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1

1

1

High-throughput

0.541

High

780355

MCD4
GPI ethanolamine phosphate transferase 1

1

1

High-throughput

0.541

High

797377

VBA2
Vacuolar basic amino acid transporter 2

1

9

High-throughput

0.541

High

797381

YHE2
Putative uncharacterized protein YHL042W

1

5

High-throughput

0.541

High

797382

ERP5
Protein ERP5

1

5

High-throughput

0.541

High

797386

SUR2
Sphingolipid C4-hydroxylase SUR2

1

2

High-throughput

0.541

High

797389

ELO1
Fatty acid elongase 1

1

5

High-throughput

0.541

High

797406

BAP3
Valine amino-acid permease

1

7

High-throughput

0.541

High

797408

EMP47
Protein EMP47

1

1

High-throughput

0.541

High

797416

GNP1
High-affinity glutamine permease

1

7

High-throughput

0.541

High

797423

YIP1
Protein transport protein YIP1

1

2

High-throughput

0.541

High

797424

ERG25
C-4 methylsterol oxidase ERG25

1

2

High-throughput

0.541

High

797427

TNA1
High-affinity nicotinic acid transporter

1

4

High-throughput

0.541

High

797436

ALG11
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase

1

1

High-throughput

0.541

High

797449

ERV41
ER-derived vesicles protein ERV41

1

2

High-throughput

0.541

High

797457

PMT7
Probable dolichyl-phosphate-mannose--protein mannosyltransferase 7

1

1

High-throughput

0.541

High

797460

THI73
Thiamine pathway transporter THI73

1

4

High-throughput

0.541

High

797465

SAM3
S-adenosylmethionine permease SAM3

1

7

High-throughput

0.541

High

797468

MMP1
S-methylmethionine permease 1

1

7

High-throughput

0.541

High

797469

EMP46
Protein EMP46

1

3

High-throughput

0.541

High

797471

TECR
Very-long-chain enoyl-CoA reductase

1

3

High-throughput

0.541

High

478412

EI2BG
Translation initiation factor eIF2B subunit gamma

2

1

Small-scale

0.521

High

555308

EI2BD
Translation initiation factor eIF2B subunit delta

2

2

Small-scale

0.521

High

575332

EI2BA
Translation initiation factor eIF2B subunit alpha

2

2

Small-scale

0.521

High

554340

HMDH1
3-hydroxy-3-methylglutaryl-coenzyme A reductase 1

1

0

High-throughput

0.518

High

583758

SEC11
Signal peptidase complex catalytic subunit SEC11

1

0

High-throughput

0.518

High

592763

ERD1
Protein ERD1

1

0

High-throughput

0.518

High

598505

ALG1
Chitobiosyldiphosphodolichol beta-mannosyltransferase

1

0

High-throughput

0.518

High

636305

ACO1
Acyl-CoA desaturase 1

1

0

High-throughput

0.518

High

763791

CSG2
Mannosyl phosphorylinositol ceramide synthase regulatory protein CSG2

1

0

High-throughput

0.518

High

793126

YRO2
Protein YRO2

1

0

High-throughput

0.518

High

797374

YPC1
Alkaline ceramidase YPC1

1

0

High-throughput

0.518

High

797376

BSD2
Metal homeostatis protein BSD2

1

0

High-throughput

0.518

High

797383

NSG1
Protein NSG1

1

0

High-throughput

0.518

High

797384

YHU0
UPF0641 membrane protein YHR140W

1

0

High-throughput

0.518

High

797385

CHS7
Chitin synthase export chaperone

1

0

High-throughput

0.518

High

797387

FET3
Iron transport multicopper oxidase FET3

1

0

High-throughput

0.518

High

797392

SEC72
Translocation protein SEC72

1

0

High-throughput

0.518

High

797400

EPS1
ER-retained PMA1-suppressing protein 1

1

0

High-throughput

0.518

High

797410

GPI2
Phosphatidylinositol N-acetylglucosaminyltransferase GPI2 subunit

1

0

High-throughput

0.518

High

797411

SPC1
Signal peptidase complex subunit 1

1

0

High-throughput

0.518

High

797413

YJY5
Uncharacterized endoplasmic reticulum membrane protein YJR015W

1

0

High-throughput

0.518

High

797417

GPI8
GPI-anchor transamidase

1

0

High-throughput

0.518

High

797429

SULX
Putative sulfate transporter YPR003C

1

0

High-throughput

0.518

High

797431

ARE2
Sterol O-acyltransferase 2

1

0

High-throughput

0.518

High

797441

OSTD
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit SWP1

1

0

High-throughput

0.518

High

797450

GSF2
Glucose-signaling factor 2

1

0

High-throughput

0.518

High

797454

CSC1
Calcium permeable stress-gated cation channel 1

1

0

High-throughput

0.518

High

797463

GUP2
Membrane-bound O-acyltransferase GUP2

1

0

High-throughput

0.518

High

797464

YP264
Probable transport protein YPL264C

1

0

High-throughput

0.518

High

797467

POM33
Pore membrane protein of 33 kDa

1

0

High-throughput

0.518

High

797470

YD206
Putative cation exchanger YDL206W

1

0

High-throughput

0.518

High

526536

HSP72
Heat shock protein SSA2

2

6

High-throughput

0.504

High

544662

SSB1
Ribosome-associated molecular chaperone SSB1

2

5

High-throughput

0.504

High

663313

FPS1
Glycerol uptake/efflux facilitator protein

1

4

High-throughput

0.494

High

745961

UGA4
GABA-specific permease

1

8

High-throughput

0.494

High

747185

PMP1
Plasma membrane ATPase proteolipid 1

1

1

High-throughput

0.494

High

780525

AVT3
Vacuolar amino acid transporter 3

1

2

High-throughput

0.494

High

782685

GEX2
Glutathione exchanger 2

1

10

High-throughput

0.494

High

794373

MAL31
Maltose permease MAL31

1

3

High-throughput

0.494

High

797380

COS8
Protein COS8

1

7

High-throughput

0.494

High

797390

UIP3
ULP1-interacting protein 3

1

7

High-throughput

0.494

High

797391

KTD1
Protein-toxin resistance protein KTD1

1

7

High-throughput

0.494

High

797397

QDR1
Quinidine resistance protein 1

1

6

High-throughput

0.494

High

797402

HXT9
Hexose transporter HXT9

1

2

High-throughput

0.494

High

797403

HXT8
Hexose transporter HXT8

1

4

High-throughput

0.494

High

797405

PMP2
Plasma membrane ATPase proteolipid 2

1

1

High-throughput

0.494

High

797407

COS4
Protein COS4

1

7

High-throughput

0.494

High

797415

COS5
Protein COS5

1

7

High-throughput

0.494

High

797422

AVT4
Vacuolar amino acid transporter 4

1

2

High-throughput

0.494

High

797425

VPS73
Vacuolar protein sorting-associated protein 73

1

8

High-throughput

0.494

High

797428

COS6
Protein COS6

1

7

High-throughput

0.494

High

797433

PDR18
ABC transporter ATP-binding protein/permease PDR18

1

1

High-throughput

0.494

High

797437

HXT11
Hexose transporter HXT11

1

4

High-throughput

0.494

High

797443

YM8M
Uncharacterized transporter YMR279C

1

9

High-throughput

0.494

High

797445

GAS3
Probable 1,3-beta-glucanosyltransferase GAS3

1

1

High-throughput

0.494

High

797453

TPO3
Polyamine transporter 3

1

6

High-throughput

0.494

High

797459

TPO1
Polyamine transporter 1

1

6

High-throughput

0.494

High

797461

GAS4
1,3-beta-glucanosyltransferase GAS4

1

1

High-throughput

0.494

High

523762

HSP71
Heat shock protein SSA1

1

6

High-throughput

0.489

High

797439

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

1

High-throughput

0.489

High

797396

ELO3
Fatty acid elongase 3

1

5

High-throughput

0.479

High

417086

VDAC1
Non-selective voltage-gated ion channel 1

1

1

High-throughput

0.470

High

420926

PMA1
Plasma membrane ATPase 1

1

2

High-throughput

0.470

High

736963

CDC3
Cell division control protein 3

1

2

High-throughput

0.470

High

797414

ARP3
Actin-related protein 3

1

2

High-throughput

0.470

High

797447

HMO1
High mobility group protein 1

1

1

High-throughput

0.470

High

797452

CORO
Coronin-like protein

1

2

High-throughput

0.470

High

678004

CWH43
Protein CWH43

1

0

High-throughput

0.458

High

679612

CDC48
Cell division control protein 48

1

0

High-throughput

0.458

High

754390

SEC66
Translocation protein SEC66

1

0

High-throughput

0.458

High

796901

PHO88
SRP-independent targeting protein 3

1

0

High-throughput

0.458

High

797399

SNL1
HSP70 co-chaperone SNL1

1

0

High-throughput

0.458

High

797401

HACD
Very-long-chain

1

0

Small-scale

0.458

High

797451

SVF1
Ceramide-binding protein SVF1

1

0

High-throughput

0.458

High

511077

COS3
Protein COS3

1

7

High-throughput

0.439

High

670630

SIS1
Protein SIS1

1

4

High-throughput

0.437

High

794956

NU170
Nucleoporin NUP170

1

1

High-throughput

0.437

High

795310

ATG8
Autophagy-related protein 8

1

1

High-throughput

0.437

High

797394

IMB4
Importin subunit beta-4

1

1

High-throughput

0.437

High

797409

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

1

High-throughput

0.437

High

797430

COPA
Coatomer subunit alpha

1

6

High-throughput

0.437

High

797435

GIS2
Zinc finger protein GIS2

1

1

High-throughput

0.437

High

792781

ANM1
Protein arginine N-methyltransferase 1

1

1

High-throughput

0.417

High

448960

TOP2
DNA topoisomerase 2

1

1

High-throughput

0.407

High

481603

HSP73
Heat shock protein SSA3

1

6

High-throughput

0.407

High

536014

SEC7
ADP-ribosylation factor guanine nucleotide-exchange factor SEC7

1

2

High-throughput

0.407

High

675955

MAS5
Mitochondrial protein import protein MAS5

1

2

High-throughput

0.407

High

737669

HIR2
Protein HIR2

1

4

High-throughput

0.407

High

737711

IF2G
Eukaryotic translation initiation factor 2 subunit gamma

1

1

High-throughput

0.407

High

797393

HSP7E
Heat shock protein SSC3, mitochondrial

1

5

High-throughput

0.407

High

797395

SSB2
Ribosome-associated molecular chaperone SSB2

1

5

High-throughput

0.407

High

797421

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

1

High-throughput

0.407

High

797412

MTC1
Maintenance of telomere capping protein 1

2

0

High-throughput

0.313

High

663600

VATO
V-type proton ATPase subunit c''

1

0

High-throughput

0.282

High

693181

PHO91
Low-affinity phosphate transporter PHO91

1

0

High-throughput

0.282

High

726061

FUN26
Nucleoside transporter FUN26

1

0

High-throughput

0.282

High

745293

TMN1
Transmembrane 9 superfamily member 1

1

0

High-throughput

0.282

High

797404

VTH2
VPS10 homolog 2

1

0

High-throughput

0.282

High

797419

CTR1
Copper transport protein CTR1

1

0

High-throughput

0.282

High

797434

PRM1
Plasma membrane fusion protein PRM1

1

0

High-throughput

0.282

High

797444

TLG1
t-SNARE affecting a late Golgi compartment protein 1

1

0

High-throughput

0.282

High

797455

OPT2
Oligopeptide transporter 2

1

0

High-throughput

0.282

High

797456

ARR3
Arsenical-resistance protein 3

1

0

High-throughput

0.282

High

797458

MCH1
Probable transporter MCH1

1

0

High-throughput

0.282

High

757922

YEL1
Guanine-nucleotide exchange factor YEL1

1

0

High-throughput

0.269

Low

797398

SLM1
Phosphatidylinositol 4,5-bisphosphate-binding protein SLM1

1

0

High-throughput

0.269

Low

797432

ARPC2
Actin-related protein 2/3 complex subunit 2

1

0

High-throughput

0.269

Low

797440

KIN4
Serine/threonine-protein kinase KIN4

1

0

High-throughput

0.269

Low

797442

COFI
Cofilin

1

0

High-throughput

0.269

Low

797466

YRA1
RNA annealing protein YRA1

1

0

High-throughput

0.269

Low

797379

KSP1
Serine/threonine-protein kinase KSP1

1

0

High-throughput

0.261

Low

740050

VPP1
V-type proton ATPase subunit a, vacuolar isoform

1

0

Small-scale

0.251

Low

758441

YKK0
Probable intramembrane protease YKL100C

1

0

High-throughput

0.249

Low

797388

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

797418

TOM22
Mitochondrial import receptor subunit TOM22

1

0

High-throughput

0.249

Low

797426

PESC
Pescadillo homolog

1

0

High-throughput

0.249

Low

797438

H3
Histone H3

1

0

High-throughput

0.249

Low

797448

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.249

Low

797462

SGO1
Shugoshin

1

0

High-throughput

0.249

Low

154160

RL36B
Large ribosomal subunit protein eL36B

1

0

High-throughput

0.232

Low

382061

H4
Histone H4

1

0

High-throughput

0.232

Low

383669

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.232

Low

394498

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.232

Low

410091

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.232

Low

427250

RLA0
Large ribosomal subunit protein uL10

1

0

High-throughput

0.232

Low

432554

RL7A
Large ribosomal subunit protein uL30A

1

0

High-throughput

0.232

Low

434007

RL33A
Large ribosomal subunit protein eL33A

1

0

High-throughput

0.232

Low

553534

PDR1
Transcription factor PDR1

1

0

High-throughput

0.232

Low

569770

RL30
Large ribosomal subunit protein eL30

1

0

High-throughput

0.232

Low

569989

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.232

Low

592206

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.232

Low

655444

RS3A2
Small ribosomal subunit protein eS1B

1

0

High-throughput

0.232

Low

684702

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.232

Low

689417

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.232

Low

743019

SWI3
SWI/SNF complex subunit SWI3

1

0

High-throughput

0.232

Low

743086

STH1
Nuclear protein STH1/NPS1

1

0

High-throughput

0.232

Low

797378

FKS1
1,3-beta-glucan synthase component FKS1

1

0

High-throughput

0.232

Low

797420

RL4B
Large ribosomal subunit protein uL4B

1

0

High-throughput

0.232

Low

797446

RUVB1
RuvB-like protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025