HitPredict

Interactor 1: KI2S4 (P43632)
Killer cell immunoglobulin-like receptor 2DS4 (CD158 antigen-like family member I) (Natural killer-associated transcript 8) (NKAT-8) (P58 natural killer cell receptor clones CL-39/CL-17) (p58 NK receptor CL-39/CL-17) (CD antigen CD158i)
Gene: KIR2DS4

Interactor 2: Q53YP1 (Q53YP1)
HLA class I histocompatibility antigen C alpha chain (HLA class I histocompatibility antigen, C alpha chain) (MHC class I antigen)
Gene: HLA-C

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.80	0.579

Property	Details
Experiments	19858347
Identification Methods	affinity chromatography technology
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	C1-set~ig, MHC_I~ig
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 304 Hs			1 366
+	Hs
		798280 KI2S4_HUMAN (1-304): 2.69e-114: 333: 100.00		Q5S3G3_HUMAN (1-365): 4.13e-179: 503: 84.66
+	Hs
		798190 KI2L3_HUMAN (1-304): 4.35e-106: 314: 88.16		Q5D1W8_HUMAN (1-366): 2.17e-170: 481: 94.54
+	Hs
		46940 KI2S1_HUMAN (1-304): 9.84e-115: 334: 91.45		A0A583ZBW8_HUMAN (1-366): 1.75e-161: 458: 94.54
+	Hs
		798193 KI2L3_HUMAN (1-304): 4.35e-106: 314: 88.16		Q5QT33_HUMAN (1-366): 3e-169: 478: 95.08
+	Hs
		46938 KI2S4_HUMAN (1-304): 2.69e-114: 333: 100.00		A0A583ZBW8_HUMAN (1-366): 1.75e-161: 458: 94.54
+	Hs
		798187 KI2L3_HUMAN (1-304): 4.35e-106: 314: 88.16		Q53YP1_HUMAN (1-366): 5.01e-169: 477: 100.00
+	Hs
		46939 KI2S5_HUMAN (1-304): 2.6e-112: 328: 87.83		A0A583ZBW8_HUMAN (1-366): 1.75e-161: 458: 94.54
+	Hs
		354354 KI2S4_HUMAN (1-304): 2.69e-114: 333: 100.00		HLAB_HUMAN (1-363): 1e-158: 451: 87.88
+	Hs
		46936 KI2S4_HUMAN (1-304): 2.69e-114: 333: 100.00		A0A583ZBW7_HUMAN (1-366): 3.48e-158: 449: 94.54
+	Hs
		488157 KI2S2_HUMAN (1-304): 9.32e-115: 335: 91.78		HLAC_HUMAN (1-366): 3.25e-156: 444: 91.26
+	Hs
		488223 KI2S1_HUMAN (1-304): 9.84e-115: 334: 91.45		HLAC_HUMAN (1-366): 3.25e-156: 444: 91.26
+	Hs
		488158 KI2S4_HUMAN (1-304): 2.69e-114: 333: 100.00		HLAC_HUMAN (1-366): 3.25e-156: 444: 91.26
+	Hs
		488222 KI2S5_HUMAN (1-304): 2.6e-112: 328: 87.83		HLAC_HUMAN (1-366): 3.25e-156: 444: 91.26
+	Hs
		3611 KI2L3_HUMAN (1-304): 4.35e-106: 314: 88.16		A0A142JA41_HUMAN (1-366): 3.79e-159: 452: 94.26
+	Hs
		354351 KI2L3_HUMAN (1-304): 4.35e-106: 314: 88.16		HLAB_HUMAN (1-363): 1e-158: 451: 87.88
+	Hs
		46935 KI2L3_HUMAN (1-304): 4.35e-106: 314: 88.16		A0A583ZBW7_HUMAN (1-366): 3.48e-158: 449: 94.54
+	Hs
		87224 KI2L3_HUMAN (1-304): 4.35e-106: 314: 88.16		C9E8W1_HUMAN (1-366): 3.12e-156: 445: 90.59
+	Hs
		488156 KI2L3_HUMAN (1-304): 4.35e-106: 314: 88.16		HLAC_HUMAN (1-366): 3.25e-156: 444: 91.26
+	Hs
		87839 KI2L3_HUMAN (1-304): 4.35e-106: 314: 88.16		D2IYK1_HUMAN (1-363): 1.21e-155: 443: 90.63
+	Hs
		673946 KI2S4_HUMAN (1-304): 2.69e-114: 333: 100.00		HLAF_HUMAN (4-349): 3.69e-143: 411: 78.04