HitPredict

Interactor 1: PRS6B (P43686)
26S proteasome regulatory subunit 6B (26S proteasome AAA-ATPase subunit RPT3) (MB67-interacting protein) (MIP224) (Proteasome 26S subunit ATPase 4) (Tat-binding protein 7) (TBP-7)
Gene: PSMC4

Interactor 2: PRS8 (P62195)
26S proteasome regulatory subunit 8 (26S proteasome AAA-ATPase subunit RPT6) (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (Thyroid hormone receptor-interacting protein 1) (TRIP1) (p45/SUG)
Gene: PSMC5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.987

The method score is based on:

Property Details
Experiments 16189514, 15604093, 17353931, 28292943, 32296183, 35271311, 35235311, 37071682, 19490896, 22275368, 28514442, 29892012, 33961781, 31515488, unassigned1304
Identification Methods two hybrid, affinity chromatography technology, pull down, cross-linking study, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, two hybrid array, validated two hybrid, two hybrid prey pooling approach, two hybrid pooling approach
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains AAA~AAA, AAA~AAA_lid_3, AAA~Prot_ATP_ID_OB, AAA_lid_3~AAA_lid_3, Prot_ATP_ID_OB~Prot_ATP_ID_OB
Common GO terms GO:0000502 - proteasome complex
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
and 6 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 418
Hs

1 406
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Last updated: 15 Jul 2024