Protein: FXL18
F-box/LRR-repeat protein 18 (F-box and leucine-rich repeat protein 18)

Gene: FXL18, FBXL18
Organism: Homo sapiens
Interactions: 53
UniProt ID: Q96ME1

Gene Ontology (top 5):
GO:0005829 - cytosol
GO:0019005 - SCF ubiquitin ligase complex
GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1031254

SKP2
S-phase kinase-associated protein 2

2

2

High-throughput

0.811

High

1041150

CUL1
Cullin-1

3

0

Small-scale

0.811

High

929036

SKP1
S-phase kinase-associated protein 1

2

0

High-throughput

0.770

High

1297760

FBXL7
F-box/LRR-repeat protein 7

1

1

Small-scale

0.747

High

228393

PRKN
E3 ubiquitin-protein ligase parkin

2

0

High-throughput

0.716

High

125656

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

3

2

High-throughput

0.653

High

1232927

FXL16
F-box/LRR-repeat protein 16

2

2

High-throughput

0.628

High

313144

MOCS3
Adenylyltransferase and sulfurtransferase MOCS3

2

0

High-throughput

0.602

High

921394

RBX1
E3 ubiquitin-protein ligase RBX1

2

0

Small-scale

0.585

High

1025512

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

2

0

High-throughput

0.559

High

1274197

RBPMS
RNA-binding protein with multiple splicing

2

0

High-throughput

0.559

High

311742

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

1

1

High-throughput

0.536

High

1297752

UHRF2
E3 ubiquitin-protein ligase UHRF2

1

0

Small-scale

0.517

High

1184944

CSN6
COP9 signalosome complex subunit 6

1

0

High-throughput

0.513

High

1272544

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.513

High

1297757

DUS16
Dual specificity protein phosphatase 16

1

0

High-throughput

0.513

High

888962

KR103
Keratin-associated protein 10-3

1

1

High-throughput

0.481

High

1023770

TRAF1
TNF receptor-associated factor 1

1

1

High-throughput

0.481

High

1297754

KR412
Keratin-associated protein 4-12

1

1

High-throughput

0.481

High

1297756

TRAF4
TNF receptor-associated factor 4

1

1

High-throughput

0.481

High

1297758

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

2

High-throughput

0.481

High

432163

HS90A
Heat shock protein HSP 90-alpha

1

1

High-throughput

0.479

High

438438

HS90B
Heat shock protein HSP 90-beta

1

1

High-throughput

0.479

High

808230

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

2

Small-scale

0.479

High

170125

PLS1
Phospholipid scramblase 1

1

0

High-throughput

0.460

High

207826

PPIP1
Proline-serine-threonine phosphatase-interacting protein 1

1

0

High-throughput

0.460

High

637982

PSA3
Proteasome subunit alpha type-3

1

0

High-throughput

0.460

High

1016842

TFCP2
Alpha-globin transcription factor CP2

1

0

High-throughput

0.460

High

1149294

K1C40
Keratin, type I cytoskeletal 40

1

0

High-throughput

0.460

High

1297761

TRIM1
Probable E3 ubiquitin-protein ligase MID2

1

1

High-throughput

0.439

High

1171288

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

795660

MAGA1
Melanoma-associated antigen 1

3

0

High-throughput

0.347

High

1157172

IIGP5
Interferon-inducible GTPase 5

2

0

High-throughput

0.328

High

1165338

LYPD4
Ly6/PLAUR domain-containing protein 4

2

0

High-throughput

0.328

High

1297755

TBL1Y
F-box-like/WD repeat-containing protein TBL1Y

2

0

High-throughput

0.328

High

1242277

PNMA1
Paraneoplastic antigen Ma1

2

0

High-throughput

0.304

High

1297753

MDFI
MyoD family inhibitor

2

0

High-throughput

0.304

High

1234856

TTC9C
Tetratricopeptide repeat protein 9C

1

0

High-throughput

0.279

Low

1030114

DHRS2
Dehydrogenase/reductase SDR family member 2, mitochondrial

1

0

High-throughput

0.269

Low

1080246

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.269

Low

904086

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

0

High-throughput

0.251

Low

995145

GOGA2
Golgin subfamily A member 2

1

0

High-throughput

0.251

Low

1044680

FHL3
Four and a half LIM domains protein 3

1

0

High-throughput

0.251

Low

1127120

MTUS2
Microtubule-associated tumor suppressor candidate 2

1

0

High-throughput

0.251

Low

1189403

NT2NA
Notch homolog 2 N-terminal-like protein A

1

0

High-throughput

0.251

Low

244802

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.249

Low

347614

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.249

Low

385361

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

489206

H14
Histone H1.4

1

0

High-throughput

0.249

Low

651991

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

670479

GNA11
Guanine nucleotide-binding protein subunit alpha-11

1

0

High-throughput

0.249

Low

1116898

ACSF3
Malonate--CoA ligase ACSF3, mitochondrial

1

0

Small-scale

0.249

Low

1297759

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024