HitPredict

Interactor 1: PRS6B (P43686)
26S proteasome regulatory subunit 6B (26S proteasome AAA-ATPase subunit RPT3) (MB67-interacting protein) (MIP224) (Proteasome 26S subunit ATPase 4) (Tat-binding protein 7) (TBP-7)
Gene: PSMC4

Interactor 2: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	35563538, 21145461
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0016020 - membrane GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 418 Hs			1 768
+	Hs
		913260 PRS10_HUMAN (35-417): 3.49e-126: 371: 40.47		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		907019 PRS8_HUMAN (38-418): 1.7e-122: 362: 42.26		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		906824 PRS4_HUMAN (32-412): 2.96e-120: 358: 49.09		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		913261 PRS10_HUMAN (35-417): 3.49e-126: 371: 40.47		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Sp
		736967 PRS4_SCHPO (43-411): 5.17e-123: 365: 52.41		CUL3_SCHPO (11-768): 0: 648: 37.04