HitPredict

Interactor 1: GATA4 (P43694)
Transcription factor GATA-4 (GATA-binding factor 4)
Gene: GATA4

Interactor 2: REQU (Q92785)
Zinc finger protein ubi-d4 (Apoptosis response zinc finger protein) (BRG1-associated factor 45D) (BAF45D) (D4, zinc and double PHD fingers family 2) (Protein requiem)
Gene: DPF2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35182466
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 442 Hs			1 391
+	Hs
		620397 GATA2_HUMAN (54-403): 4.51e-44: 162: 38.66		REQU_HUMAN (1-391): 1.89e-101: 307: 100.00
+	Hs
		554491 GATA1_HUMAN (90-422): 4.68e-40: 150: 35.44		REQU_HUMAN (1-391): 1.89e-101: 307: 100.00
+	Hs
		620396 GATA2_HUMAN (54-403): 4.51e-44: 162: 38.66		DPF1_HUMAN (1-385): 1.2e-87: 272: 56.25
+	Hs
		554490 GATA1_HUMAN (90-422): 4.68e-40: 150: 35.44		DPF1_HUMAN (1-385): 1.2e-87: 272: 56.25
+	Hs
		798897 GATA4_HUMAN (1-442): 5.21e-80: 256: 100.00		CHD4_HUMAN (32-382): 5.17e-44: 165: 12.73
+	Hs
		798998 GATA4_HUMAN (1-442): 5.21e-80: 256: 100.00		KDM5D_HUMAN (122-391): 6.33e-37: 144: 18.75
+	Hs
		798868 GATA4_HUMAN (1-442): 5.21e-80: 256: 100.00		KMT2A_HUMAN (80-388): 8.66e-36: 141: 14.38
+	Hs
		798952 GATA4_HUMAN (1-442): 5.21e-80: 256: 100.00		PHF10_HUMAN (226-384): 1.03e-31: 127: 35.19
+	Mm
		140194 GATA2_MOUSE (54-403): 6.02e-45: 164: 38.38		TRI33_MOUSE (6-389): 2.47e-52: 189: 12.69
+	Hs
		1018736 TRPS1_HUMAN (178-437): 1.43e-43: 165: 24.63		CHD3_HUMAN (43-382): 1.44e-49: 181: 13.23
+	Hs
		799030 GATA4_HUMAN (1-442): 5.21e-80: 256: 100.00		BAZ2A_HUMAN (329-375): 3.73e-18: 88.7: 51.06
+	Mm
		570300 GATA1_MOUSE (52-419): 4.58e-38: 144: 32.88		TRI33_MOUSE (6-389): 2.47e-52: 189: 12.69
+	Hs
		1059926 TRPS1_HUMAN (178-437): 1.43e-43: 165: 24.63		CHD4_HUMAN (32-382): 5.17e-44: 165: 12.73
+	Mm
		570297 GATA1_MOUSE (52-419): 4.58e-38: 144: 32.88		CHD4_MOUSE (32-382): 9.67e-44: 164: 12.73
+	Hs
		170258 GATA2_HUMAN (54-403): 4.51e-44: 162: 38.66		TIF1A_HUMAN (25-391): 1.7e-32: 131: 14.06
+	Mm
		140187 GATA2_MOUSE (54-403): 6.02e-45: 164: 38.38		KMT2A_MOUSE (80-387): 1.83e-28: 120: 14.56
+	Hs
		152589 GATA2_HUMAN (54-403): 4.51e-44: 162: 38.66		KMT2D_HUMAN (241-382): 8.36e-23: 102: 30.77
+	Hs
		152586 GATA1_HUMAN (90-422): 4.68e-40: 150: 35.44		KMT2D_HUMAN (241-382): 8.36e-23: 102: 30.77
+	Hs
		152590 GATA3_HUMAN (43-387): 3.5e-35: 137: 35.17		KMT2D_HUMAN (241-382): 8.36e-23: 102: 30.77
+	Hs
		620385 GATA2_HUMAN (54-403): 4.51e-44: 162: 38.66		KMT2C_HUMAN (266-376): 2.95e-09: 61.3: 22.22