HitPredict

Interactor 1: CBX5 (P45973)
Chromobox protein homolog 5 (Antigen p25) (Heterochromatin protein 1 homolog alpha) (HP1 alpha)
Gene: CBX5

Interactor 2: SETB1 (Q15047)
Histone-lysine N-methyltransferase SETDB1 (EC 2.1.1.366) (ERG-associated protein with SET domain) (ESET) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (Lysine N-methyltransferase 1E) (SET domain bifurcated 1)
Gene: SETDB1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	19498464
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 191 Hs			1 1291
+	Hs
		1027006 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		SETB1_HUMAN (1-1291): 0: 1373: 100.00
+	Hs
		800530 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		EHMT1_HUMAN (995-1287): 5.59e-70: 259: 21.27
+	Hs
		203638 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		SUV91_HUMAN (658-972): 1.59e-70: 244: 22.56
+	Hs
		203823 V9HWG0_HUMAN (1-191): 1.24e-68: 209: 100.00		SUV91_HUMAN (658-972): 1.59e-70: 244: 22.56
+	Hs
		1027268 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		EHMT1_HUMAN (995-1287): 5.59e-70: 259: 21.27
+	Mm
		1143050 CBX5_MOUSE (1-191): 1.9e-68: 208: 97.91		EHMT2_MOUSE (999-1287): 7.04e-65: 243: 19.11
+	Hs
		800497 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		EHMT2_HUMAN (999-1287): 2.75e-64: 241: 19.11
+	Mm
		222467 CBX5_MOUSE (1-191): 1.9e-68: 208: 97.91		SUV91_MOUSE (658-970): 1.78e-68: 238: 22.39
+	Hs
		1331984 V9HWG0_HUMAN (1-191): 1.24e-68: 209: 100.00		SUV92_HUMAN (973-1290): 2.24e-67: 235: 20.98
+	Hs
		800527 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		SUV92_HUMAN (973-1290): 2.24e-67: 235: 20.98
+	Mm
		1125433 Q9DCC5_MOUSE (1-181): 3.06e-62: 192: 60.22		EHMT1_MOUSE (995-1287): 2.13e-66: 248: 21.84
+	Hs
		203674 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		SUV91_HUMAN (658-972): 1.59e-70: 244: 22.56
+	Hs
		1027194 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		EHMT2_HUMAN (999-1287): 2.75e-64: 241: 19.11
+	Mm
		222468 Q9DCC5_MOUSE (1-181): 3.06e-62: 192: 60.22		SUV91_MOUSE (658-970): 1.78e-68: 238: 22.39
+	Hs
		1027262 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		SUV92_HUMAN (973-1290): 2.24e-67: 235: 20.98
+	Hs
		800516 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		SETD2_HUMAN (911-1290): 1.29e-53: 209: 16.00
+	Hs
		1027242 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		SETD2_HUMAN (911-1290): 1.29e-53: 209: 16.00
+	Mm
		936655 Q9DCC5_MOUSE (1-181): 3.06e-62: 192: 60.22		EZH1_MOUSE (1026-1272): 2.84e-55: 208: 13.90
+	Hs
		800391 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		EZH2_HUMAN (1026-1272): 1.18e-48: 188: 13.13
+	Mm
		1142272 CBX5_MOUSE (1-191): 1.9e-68: 208: 97.91		EZH2_MOUSE (1026-1272): 1.15e-48: 188: 13.13