HitPredict

Interactor 1: CBX5 (P45973)
Chromobox protein homolog 5 (Antigen p25) (Heterochromatin protein 1 homolog alpha) (HP1 alpha)
Gene: CBX5

Interactor 2: Z518A (Q6AHZ1)
Zinc finger protein 518A
Gene: ZNF518A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	27705803, 20562864
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0006325 - chromatin organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 191 Hs			1 1483
+	Hs
		800406 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		Z585B_HUMAN (140-758): 0: 692: 14.97
+	Hs
		64135 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		ZN729_HUMAN (179-757): 0: 590: 12.62
+	Hs
		64140 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		ZN729_HUMAN (179-757): 0: 590: 12.62
+	Hs
		800410 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		ZN678_HUMAN (56-476): 7.95e-179: 545: 17.56
+	Hs
		800447 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		ZN227_HUMAN (216-814): 1.16e-174: 544: 12.36
+	Hs
		64158 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		ZN726_HUMAN (180-654): 9.44e-154: 482: 14.67
+	Hs
		800350 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		ZNF45_HUMAN (125-518): 3.3e-116: 383: 16.92
+	Hs
		800355 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		ZN543_HUMAN (52-377): 2.43e-98: 330: 18.75
+	Hs
		800402 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		ZN568_HUMAN (233-517): 4.92e-96: 325: 15.12
+	Hs
		800409 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		ZN569_HUMAN (462-765): 3.31e-88: 304: 12.20
+	Hs
		800498 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		ZN578_HUMAN (171-414): 2.68e-58: 214: 16.79
+	Hs
		67424 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		ZN850_HUMAN (538-759): 4.91e-41: 167: 10.81
+	Hs
		800518 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		Z518B_HUMAN (94-468): 3.28e-23: 109: 27.37
+	Hs
		800425 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		Z585A_HUMAN (583-801): 7.43e-20: 98.1: 7.69
+	Mm
		111412 CBX5_MOUSE (1-191): 1.9e-68: 208: 97.91		J3QPN0_MOUSE (94-466): 2.54e-18: 93.6: 24.87
+	Mm
		70612 CBX5_MOUSE (1-191): 1.9e-68: 208: 97.91		Z518A_MOUSE (2-143): 1.71e-12: 74.6: 11.33
+	Hs
		67855 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		ZN724_HUMAN (1-64): 4.17e-12: 72.7: 7.35
+	Mm
		1143039 CBX5_MOUSE (1-191): 1.9e-68: 208: 97.91		REST_MOUSE (136-285): 2.84e-10: 67.4: 26.67
+	Hs
		800481 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		ZN566_HUMAN (69-280): 7.28e-10: 65.1: 25.57
+	Hs
		800552 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		ZN222_HUMAN (140-294): 8.12e-10: 65.1: 29.94