HitPredict

Interactor 1: CBX5 (P45973)
Chromobox protein homolog 5 (Antigen p25) (Heterochromatin protein 1 homolog alpha) (HP1 alpha)
Gene: CBX5

Interactor 2: ADNP (Q9H2P0)
Activity-dependent neuroprotector homeobox protein (Activity-dependent neuroprotective protein)
Gene: ADNP

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.697

Property	Details
Experiments	24981860, 27705803, 21888893, 20562864
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 191 Hs			1 1102
+	Mm
		1143028 CBX5_MOUSE (1-191): 1.9e-68: 208: 97.91		Q6ZQ47_MOUSE (20-1102): 0: 1867: 93.49
+	Hs
		1027253 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		ADNP_HUMAN (1-1102): 0: 1877: 100.00
+	Mm
		1169697 Q9DCC5_MOUSE (1-181): 3.06e-62: 192: 60.22		Q6ZQ47_MOUSE (20-1102): 0: 1867: 93.49
+	Hs
		949882 CBX1_HUMAN (26-180): 2.32e-55: 175: 60.65		ADNP_HUMAN (1-1102): 0: 1877: 100.00
+	Mm
		949944 CBX1_MOUSE (26-180): 2.32e-55: 175: 60.65		Q6ZQ47_MOUSE (20-1102): 0: 1867: 93.49
+	Hs
		800419 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		ADNP2_HUMAN (1-413): 5.4e-145: 466: 27.87
+	Hs
		1027053 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		ADNP2_HUMAN (1-413): 5.4e-145: 466: 27.87
+	Hs
		949813 CBX1_HUMAN (26-180): 2.32e-55: 175: 60.65		ADNP2_HUMAN (1-413): 5.4e-145: 466: 27.87
+	Mm
		1208472 Q9DCC5_MOUSE (1-181): 3.06e-62: 192: 60.22		ADNP2_MOUSE (1-421): 2.25e-137: 446: 27.75
+	Mm
		949955 CBX1_MOUSE (26-180): 2.32e-55: 175: 60.65		ADNP2_MOUSE (1-421): 2.25e-137: 446: 27.75