HitPredict

Interactor 1: UBP5 (P45974)
Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.4.19.12) (Deubiquitinating enzyme 5) (Isopeptidase T) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5)
Gene: USP5

Interactor 2: RD23A (P54725)
UV excision repair protein RAD23 homolog A (HR23A) (hHR23A)
Gene: RAD23A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	19013454
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	UBA~UBA, UBA~ubiquitin, UBA~XPC-binding, UCH~ubiquitin, ubiquitin~zf-UBP
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0032436 - positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0043130 - ubiquitin binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 858 Hs			1 363
+	Rn
		88802 D3ZVQ0_RAT (1-858): 0: 845: 98.25		RD23B_RAT (3-363): 6.38e-109: 326: 52.05
+	Hs
		800568 UBP5_HUMAN (1-858): 0: 842: 100.00		RD23B_HUMAN (3-363): 1.37e-106: 320: 54.03
+	Hs
		872196 UBP13_HUMAN (2-858): 0: 721: 59.47		RD23A_HUMAN (1-363): 4.01e-119: 350: 100.00
+	Hs
		474951 UBP5_HUMAN (1-858): 0: 842: 100.00		UBB_HUMAN (3-81): 4.96e-28: 111: 30.38
+	Hs
		800571 UBP5_HUMAN (1-858): 0: 842: 100.00		RS27A_HUMAN (3-93): 2.9e-16: 77.1: 27.47
+	Hs
		1273584 UBP13_HUMAN (2-858): 0: 721: 59.47		UBQL2_HUMAN (2-312): 1.85e-45: 166: 16.08
+	Hs
		803679 UBP13_HUMAN (2-858): 0: 721: 59.47		BAG6_HUMAN (2-307): 5.25e-38: 146: 15.22
+	Dm
		547964 Q9VZU7_DROME (7-855): 0: 631: 48.79		RS27A_DROME (3-93): 5.65e-16: 76.4: 27.47
+	Sc
		477617 UBP14_YEAST (11-855): 4.13e-125: 397: 26.43		RL40A_YEAST (3-129): 1.25e-32: 120: 20.47
+	Hs
		924372 USP9X_HUMAN (289-758): 2.24e-84: 298: 16.20		RL40_HUMAN (3-129): 1.37e-38: 136: 22.84
+	Hs
		803680 UBP7_HUMAN (247-777): 7.21e-80: 281: 13.17		BAG6_HUMAN (2-307): 5.25e-38: 146: 15.22
+	Hs
		924373 UBP7_HUMAN (247-777): 7.21e-80: 281: 13.17		RL40_HUMAN (3-129): 1.37e-38: 136: 22.84
+	Hs
		905374 UBP46_HUMAN (293-681): 1.18e-80: 266: 14.90		RL40_HUMAN (3-129): 1.37e-38: 136: 22.84
+	Rn
		94336 UBP46_RAT (293-681): 1.37e-80: 266: 14.90		RL40_RAT (3-129): 1.37e-38: 136: 22.84
+	Hs
		475123 UBP7_HUMAN (247-777): 7.21e-80: 281: 13.17		UBB_HUMAN (3-81): 4.96e-28: 111: 30.38
+	Hs
		474982 UBP46_HUMAN (293-681): 1.18e-80: 266: 14.90		UBB_HUMAN (3-81): 4.96e-28: 111: 30.38
+	Hs
		924100 USP9X_HUMAN (289-758): 2.24e-84: 298: 16.20		RS27A_HUMAN (3-93): 2.9e-16: 77.1: 27.47
+	Hs
		924201 UBP36_HUMAN (250-817): 9.73e-85: 295: 13.61		RS27A_HUMAN (3-93): 2.9e-16: 77.1: 27.47
+	Hs
		271114 UBP2_HUMAN (700-854): 1.43e-11: 70.1: 16.05		Q5U5U6_HUMAN (3-81): 4.96e-28: 111: 30.38