HitPredict

Interactor 1: MK08 (P45983)
Mitogen-activated protein kinase 8 (MAP kinase 8) (MAPK 8) (EC 2.7.11.24) (JNK-46) (Stress-activated protein kinase 1c) (SAPK1c) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1)
Gene: MAPK8

Interactor 2: CDN1B (P46527)
Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1)
Gene: CDKN1B

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	1.00	0.724

Property	Details
Experiments	12963725
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	CDI~Pkinase
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019903 - protein phosphatase binding and 1 others more... GO:0090398 - cellular senescence
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 427 Hs			1 198
+	Hs
		804088 MK10_HUMAN (1-427): 6.5e-163: 468: 90.16		CDN1B_HUMAN (1-198): 1.46e-79: 237: 100.00
+	Hs
		625207 CDK2_HUMAN (23-329): 1.82e-136: 394: 33.23		CDN1B_HUMAN (1-198): 1.46e-79: 237: 100.00
+	Hs
		758145 MK08_HUMAN (1-427): 6.2e-164: 469: 100.00		CDN1A_HUMAN (17-167): 1.06e-46: 152: 27.10
+	Rn
		139842 CDK2_RAT (23-329): 1.82e-136: 394: 33.55		O08769_RAT (1-197): 2.3e-73: 221: 86.80
+	Hs
		804104 CDK3_HUMAN (23-329): 8.57e-130: 378: 33.55		CDN1B_HUMAN (1-198): 1.46e-79: 237: 100.00
+	Hs
		800725 MK08_HUMAN (1-427): 6.2e-164: 469: 100.00		CDN1C_HUMAN (1-123): 4.27e-27: 106: 35.42
+	Xl
		616668 CDK2_XENLA (23-329): 4.08e-135: 391: 33.55		Q91646_XENLA (14-190): 2.49e-51: 166: 26.00
+	Xl
		1153623 Q6IRQ7_XENLA (23-329): 2.1e-134: 389: 33.23		Q91646_XENLA (14-190): 2.49e-51: 166: 26.00
+	Hs
		625186 CDK2_HUMAN (23-329): 1.82e-136: 394: 33.23		CDN1A_HUMAN (17-167): 1.06e-46: 152: 27.10
+	Hs
		758248 MK14_HUMAN (4-365): 2.33e-130: 381: 46.03		CDN1A_HUMAN (17-167): 1.06e-46: 152: 27.10
+	Hs
		758188 CDK3_HUMAN (23-329): 8.57e-130: 378: 33.55		CDN1A_HUMAN (17-167): 1.06e-46: 152: 27.10
+	Hs
		625237 CDK2_HUMAN (23-329): 1.82e-136: 394: 33.23		CDN1C_HUMAN (1-123): 4.27e-27: 106: 35.42
+	Mm
		803839 MK01_MOUSE (20-359): 2.95e-84: 263: 42.98		CDN1B_MOUSE (1-197): 4.44e-75: 225: 87.31
+	Mm
		803846 MK03_MOUSE (20-370): 9.11e-84: 263: 40.56		CDN1B_MOUSE (1-197): 4.44e-75: 225: 87.31
+	Hs
		836898 CDK3_HUMAN (23-329): 8.57e-130: 378: 33.55		CDN1C_HUMAN (1-123): 4.27e-27: 106: 35.42