HitPredict

Interactor 1: MK08 (P45983)
Mitogen-activated protein kinase 8 (MAP kinase 8) (MAPK 8) (EC 2.7.11.24) (JNK-46) (Stress-activated protein kinase 1c) (SAPK1c) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1)
Gene: MAPK8

Interactor 2: CDN1C (P49918)
Cyclin-dependent kinase inhibitor 1C (Cyclin-dependent kinase inhibitor p57) (p57Kip2)
Gene: CDKN1C

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	12963725
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CDI~Pkinase
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 427 Hs			1 316
+	Hs
		758145 MK08_HUMAN (1-427): 6.2e-164: 469: 100.00		CDN1A_HUMAN (17-148): 7.59e-31: 115: 29.20
+	Hs
		800718 MK08_HUMAN (1-427): 6.2e-164: 469: 100.00		CDN1B_HUMAN (9-201): 9.76e-25: 100: 21.76
+	Hs
		804088 MK10_HUMAN (1-427): 6.5e-163: 468: 90.16		CDN1B_HUMAN (9-201): 9.76e-25: 100: 21.76
+	Hs
		625237 CDK2_HUMAN (23-329): 1.82e-136: 394: 33.23		CDN1C_HUMAN (1-316): 3.21e-37: 137: 100.00
+	Hs
		836898 CDK3_HUMAN (23-329): 8.57e-130: 378: 33.55		CDN1C_HUMAN (1-316): 3.21e-37: 137: 100.00
+	Hs
		625186 CDK2_HUMAN (23-329): 1.82e-136: 394: 33.23		CDN1A_HUMAN (17-148): 7.59e-31: 115: 29.20
+	Hs
		758248 MK14_HUMAN (4-365): 2.33e-130: 381: 46.03		CDN1A_HUMAN (17-148): 7.59e-31: 115: 29.20
+	Rn
		139842 CDK2_RAT (23-329): 1.82e-136: 394: 33.55		O08769_RAT (9-201): 8.07e-25: 100: 24.35
+	Hs
		625207 CDK2_HUMAN (23-329): 1.82e-136: 394: 33.23		CDN1B_HUMAN (9-201): 9.76e-25: 100: 21.76
+	Hs
		758188 CDK3_HUMAN (23-329): 8.57e-130: 378: 33.55		CDN1A_HUMAN (17-148): 7.59e-31: 115: 29.20
+	Hs
		804104 CDK3_HUMAN (23-329): 8.57e-130: 378: 33.55		CDN1B_HUMAN (9-201): 9.76e-25: 100: 21.76
+	Xl
		616668 CDK2_XENLA (23-329): 4.08e-135: 391: 33.55		Q91646_XENLA (26-155): 1.89e-17: 81.3: 28.46
+	Xl
		1153623 Q6IRQ7_XENLA (23-329): 2.1e-134: 389: 33.23		Q91646_XENLA (26-155): 1.89e-17: 81.3: 28.46
+	Hs
		625528 CDK2_HUMAN (23-329): 1.82e-136: 394: 33.23		TITIN_HUMAN (92-310): 7.91e-10: 62.3: 9.77
+	Rn
		926487 MK01_RAT (20-359): 2.95e-84: 263: 42.98		SYNJ1_RAT (62-316): 8.86e-28: 115: 16.09
+	Mm
		803839 MK01_MOUSE (20-359): 2.95e-84: 263: 42.98		CDN1B_MOUSE (9-201): 1.47e-28: 110: 23.83
+	Mm
		803846 MK03_MOUSE (20-370): 9.11e-84: 263: 40.56		CDN1B_MOUSE (9-201): 1.47e-28: 110: 23.83
+	Hs
		659014 MK01_HUMAN (20-359): 2.94e-84: 263: 42.98		TITIN_HUMAN (92-310): 7.91e-10: 62.3: 9.77