HitPredict

Interactor 1: MK08 (P45983)
Mitogen-activated protein kinase 8 (MAP kinase 8) (MAPK 8) (EC 2.7.11.24) (JNK-46) (Stress-activated protein kinase 1c) (SAPK1c) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1)
Gene: MAPK8

Interactor 2: HSF1 (Q00613)
Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1)
Gene: HSF1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.66 0.60 0.633

The method score is based on:

Property Details
Experiments 10747973, 27043084
Identification Methods pull down, anti bait coimmunoprecipitation, in-gel kinase assay
Interaction Type direct interaction, physical association, phosphorylation reaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0010628 - positive regulation of gene expression
and 2 others

more...
Homologous interactions 8

Homologous interactions

Color coding for hit scores

1 427
Hs

1 529
+ Hs
+ Hs
+ At
+ Hs
+ Hs
+ At
+ At
+ At

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024