Protein: CDC6
Cell division control protein 6 homolog (CDC6-related protein) (Cdc18-related protein) (HsCdc18) (p62(cdc6)) (HsCDC6)

Gene: CDC6
Organism: Homo sapiens
Interactions: 115
UniProt ID: Q99741

Gene Ontology (top 5):
GO:0000076 - DNA replication checkpoint signaling
GO:0000079 - regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000166 - nucleotide binding
GO:0000922 - spindle pole
GO:0003682 - chromatin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1104326

ORC1
Origin recognition complex subunit 1

3

15

Small-scale

0.882

High

1104364

ORC2
Origin recognition complex subunit 2

2

12

Small-scale

0.821

High

831309

CCNF
Cyclin-F

4

10

Small-scale

0.702

High

230918

ORC5
Origin recognition complex subunit 5

1

19

High-throughput

0.692

High

1406954

ORC3
Origin recognition complex subunit 3

1

12

High-throughput

0.692

High

1406969

ORC6
Origin recognition complex subunit 6

1

6

High-throughput

0.692

High

1406949

CDT1
DNA replication factor Cdt1

4

2

Small-scale

0.689

High

629158

CCNA2
Cyclin-A2

3

7

Small-scale

0.667

High

789004

TGFR2
TGF-beta receptor type-2

3

1

High-throughput

0.667

High

756314

MCM7
DNA replication licensing factor MCM7

3

17

Small-scale

0.661

High

1406962

FZR1
Fizzy-related protein homolog

3

4

Small-scale

0.655

High

705919

TNR8
Tumor necrosis factor receptor superfamily member 8

2

7

High-throughput

0.628

High

1406947

GRWD1
Glutamate-rich WD repeat-containing protein 1

2

5

Small-scale

0.624

High

443494

CDK1
Cyclin-dependent kinase 1

2

11

Small-scale

0.621

High

1406946

CDC6
Cell division control protein 6 homolog

1

14

Small-scale

0.618

High

669984

MCM3
DNA replication licensing factor MCM3

2

20

Small-scale

0.611

High

888278

MCM2
DNA replication licensing factor MCM2

2

19

Small-scale

0.611

High

920232

PLK1
Serine/threonine-protein kinase PLK1

1

2

Small-scale

0.604

High

1293559

F131B
Protein FAM131B

2

0

High-throughput

0.602

High

1359147

GLMP
Glycosylated lysosomal membrane protein

2

0

High-throughput

0.602

High

668006

CDK2
Cyclin-dependent kinase 2

2

11

Small-scale

0.595

High

372957

MYC
Myc proto-oncogene protein

1

4

Small-scale

0.578

High

848817

MAGAA
Melanoma-associated antigen 10

2

0

High-throughput

0.576

High

562348

LAMP2
Lysosome-associated membrane glycoprotein 2

2

2

High-throughput

0.574

High

622669

TNR1A
Tumor necrosis factor receptor superfamily member 1A

2

8

High-throughput

0.574

High

1406966

PCDBB
Protocadherin beta-11

2

1

High-throughput

0.574

High

1280437

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

6

Small-scale

0.573

High

1406970

P2R3B
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta

1

1

Small-scale

0.573

High

1108079

SQSTM
Sequestosome-1

2

2

Small-scale

0.563

High

1109499

ATR
Serine/threonine-protein kinase ATR

1

5

Small-scale

0.561

High

549224

CDK4
Cyclin-dependent kinase 4

1

13

Small-scale

0.550

High

1025412

CDK6
Cyclin-dependent kinase 6

1

12

Small-scale

0.550

High

549019

KPSH1
Serine/threonine-protein kinase H1

1

0

Small-scale

0.537

High

842844

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

3

High-throughput

0.536

High

1272252

MCM10
Protein MCM10 homolog

1

4

High-throughput

0.536

High

127721

TR10A
Tumor necrosis factor receptor superfamily member 10A

1

7

High-throughput

0.536

High

141067

NOP56
Nucleolar protein 56

1

5

High-throughput

0.536

High

156332

G3PT
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific

1

2

High-throughput

0.536

High

1161197

MK06
Mitogen-activated protein kinase 6

1

4

High-throughput

0.536

High

1334526

RN149
E3 ubiquitin-protein ligase RNF149

1

2

High-throughput

0.536

High

1369476

TANK
TRAF family member-associated NF-kappa-B activator

1

1

High-throughput

0.536

High

1406971

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

1

High-throughput

0.536

High

346680

TTC4
Tetratricopeptide repeat protein 4

1

2

Small-scale

0.526

High

957656

UBE2K
Ubiquitin-conjugating enzyme E2 K

1

0

High-throughput

0.518

High

808152

CDN1A
Cyclin-dependent kinase inhibitor 1

1

0

High-throughput

0.513

High

260795

RAMP2
Receptor activity-modifying protein 2

1

0

High-throughput

0.513

High

349702

BPNT1
3'(2'),5'-bisphosphate nucleotidase 1

1

0

High-throughput

0.513

High

867668

GPR12
G-protein coupled receptor 12

1

0

High-throughput

0.513

High

1406953

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

0

High-throughput

0.513

High

1054204

P2R3A
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha

1

1

Small-scale

0.512

High

332038

KAT7
Histone acetyltransferase KAT7

1

3

Small-scale

0.501

High

508504

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

6

High-throughput

0.501

High

573881

CCNB1
G2/mitotic-specific cyclin-B1

1

8

Small-scale

0.501

High

667008

CCNE1
G1/S-specific cyclin-E1

1

8

Small-scale

0.501

High

928529

TERF1
Telomeric repeat-binding factor 1

1

1

Small-scale

0.501

High

1086897

CDC20
Cell division cycle protein 20 homolog

1

5

Small-scale

0.501

High

1102239

ATM
Serine-protein kinase ATM

1

5

Small-scale

0.501

High

1406964

CC14A
Dual specificity protein phosphatase CDC14A

1

7

Small-scale

0.501

High

182747

GP182
G-protein coupled receptor 182

1

1

High-throughput

0.489

High

630342

TNR1B
Tumor necrosis factor receptor superfamily member 1B

1

7

High-throughput

0.489

High

688618

NKG2A
NKG2-A/NKG2-B type II integral membrane protein

1

1

High-throughput

0.489

High

706274

S10A2
Protein S100-A2

1

1

High-throughput

0.489

High

1177183

MICB
MHC class I polypeptide-related sequence B

1

1

High-throughput

0.489

High

1406950

CAD23
Cadherin-23

1

1

High-throughput

0.489

High

1406959

PNMA2
Paraneoplastic antigen Ma2

1

2

High-throughput

0.489

High

1406963

EDAR
Tumor necrosis factor receptor superfamily member EDAR

1

6

High-throughput

0.489

High

1406965

LAMP3
Lysosome-associated membrane glycoprotein 3

1

2

High-throughput

0.489

High

1406967

PCDG5
Protocadherin gamma-A5

1

1

High-throughput

0.489

High

551223

PCNA
Proliferating cell nuclear antigen

1

8

Small-scale

0.481

High

185957

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.480

High

1311093

UBR1
E3 ubiquitin-protein ligase UBR1

1

0

Small-scale

0.480

High

1360341

ATRIP
ATR-interacting protein

1

0

Small-scale

0.480

High

273449

KDM4A
Lysine-specific demethylase 4A

1

5

Small-scale

0.479

High

294232

CD123
Translation initiation factor eIF2 assembly protein

1

3

High-throughput

0.479

High

414490

P53
Cellular tumor antigen p53

1

2

High-throughput

0.479

High

507335

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

6

Small-scale

0.479

High

756028

MCM5
DNA replication licensing factor MCM5

1

19

Small-scale

0.479

High

765829

BMI1
Polycomb complex protein BMI-1

1

5

Small-scale

0.479

High

980209

H4
Histone H4

1

9

High-throughput

0.479

High

1045694

TF65
Transcription factor p65

1

7

High-throughput

0.479

High

1118141

DX39B
Spliceosome RNA helicase DDX39B

1

1

Small-scale

0.479

High

1161373

HIF1A
Hypoxia-inducible factor 1-alpha

1

4

Small-scale

0.479

High

1368580

KAT6A
Histone acetyltransferase KAT6A

1

6

High-throughput

0.479

High

1397351

CI072
Guanine nucleotide exchange factor C9orf72

1

3

High-throughput

0.479

High

1406951

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.479

High

1406956

LRWD1
Leucine-rich repeat and WD repeat-containing protein 1

1

2

Small-scale

0.479

High

1406958

MCM8
DNA helicase MCM8

1

20

Small-scale

0.479

High

608720

DDX5
Probable ATP-dependent RNA helicase DDX5

1

0

Small-scale

0.458

High

1406961

AKP8L
A-kinase anchor protein 8-like

1

0

Small-scale

0.458

High

1406968

HEY1
Hairy/enhancer-of-split related with YRPW motif protein 1

1

0

Small-scale

0.458

High

562854

CCL2
C-C motif chemokine 2

1

1

Small-scale

0.437

High

1406948

COL11
Collectin-11

1

1

High-throughput

0.437

High

1406960

HECD1
E3 ubiquitin-protein ligase HECTD1

1

6

High-throughput

0.437

High

1330132

PCD20
Protocadherin-20

1

2

High-throughput

0.407

High

154868

ISLR
Immunoglobulin superfamily containing leucine-rich repeat protein

3

0

High-throughput

0.347

High

252711

TSN3
Tetraspanin-3

3

0

High-throughput

0.347

High

653733

PROZ
Vitamin K-dependent protein Z

2

0

High-throughput

0.328

High

1406952

MANS1
MANSC domain-containing protein 1

2

0

High-throughput

0.328

High

1406957

I20RA
Interleukin-20 receptor subunit alpha

2

0

High-throughput

0.328

High

1143779

PON2
Serum paraoxonase/arylesterase 2

2

0

High-throughput

0.318

High

292301

B3GL1
UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1

1

0

High-throughput

0.282

High

73848

C1T9B
Complement C1q and tumor necrosis factor-related protein 9B

1

0

High-throughput

0.279

Low

286582

SG2A1
Mammaglobin-B

1

0

High-throughput

0.279

Low

488847

FURIN
Furin

1

0

High-throughput

0.279

Low

880190

PTH2R
Parathyroid hormone 2 receptor

1

0

High-throughput

0.279

Low

1101641

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

0

High-throughput

0.279

Low

1105547

OS9
Protein OS-9

1

0

High-throughput

0.279

Low

1193162

TIGIT
T-cell immunoreceptor with Ig and ITIM domains

1

0

High-throughput

0.279

Low

1213685

LRAD1
Low-density lipoprotein receptor class A domain-containing protein 1

1

0

High-throughput

0.279

Low

1219233

CDCP2
CUB domain-containing protein 2

1

0

High-throughput

0.279

Low

1406955

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.279

Low

222319

PSCA
Prostate stem cell antigen

1

0

High-throughput

0.232

Low

388446

B3AT
Band 3 anion transport protein

1

0

High-throughput

0.232

Low

1208270

SPXN3
Sperm protein associated with the nucleus on the X chromosome N3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025