HitPredict

Interactor 1: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Interactor 2: TNFL6 (P48023)
Tumor necrosis factor ligand superfamily member 6 (Apoptosis antigen ligand) (APTL) (CD95 ligand) (CD95-L) (Fas antigen ligand) (Fas ligand) (FasL) (CD antigen CD178) [Cleaved into: Tumor necrosis factor ligand superfamily member 6, membrane form; Tumor necrosis factor ligand superfamily member 6, soluble form (Receptor-binding FasL ectodomain) (Soluble Fas ligand) (sFasL); ADAM10-processed FasL form (APL); FasL intracellular domain (FasL ICD) (SPPL2A-processed FasL form) (SPA)]
Gene: FASLG

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	19807924
Identification Methods	unspecified method, phage display
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0070062 - extracellular exosome
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 304 Hs			1 281
+	Hs
		815690 DNMBP_HUMAN (119-293): 5.7e-46: 168: 29.35		TNFL6_HUMAN (1-281): 1.11e-121: 350: 100.00
+	Hs
		275179 GRAP2_HUMAN (1-296): 5.17e-33: 125: 17.17		TNFL6_HUMAN (1-281): 1.11e-121: 350: 100.00
+	Hs
		815671 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		TNFL6_HUMAN (1-281): 1.11e-121: 350: 100.00
+	Hs
		815678 GRAP_HUMAN (135-294): 3.79e-21: 91.4: 16.67		TNFL6_HUMAN (1-281): 1.11e-121: 350: 100.00
+	Hs
		815714 ITSN2_HUMAN (189-304): 5.82e-12: 68.3: 11.86		TNFL6_HUMAN (1-281): 1.11e-121: 350: 100.00
+	Hs
		209004 NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00		TNFL6_HUMAN (1-281): 1.11e-121: 350: 100.00
+	Hs
		557638 NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00		TNFL6_HUMAN (1-281): 1.11e-121: 350: 100.00