Protein: SYSC
Serine--tRNA ligase, cytoplasmic (EC 6.1.1.11) (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser/Sec) synthetase)

Gene: SYSC, SARS1
Organism: Homo sapiens
Interactions: 111
UniProt ID: P49591

Gene Ontology (top 5):
GO:0000049 - tRNA binding
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001514 - selenocysteine incorporation
GO:0002181 - cytoplasmic translation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

884768

SIR2
NAD-dependent protein deacetylase sirtuin-2

4

3

High-throughput

0.697

High

884760

FRPD2
FERM and PDZ domain-containing protein 2

3

3

High-throughput

0.667

High

884733

SYSC
Serine--tRNA ligase, cytoplasmic

1

14

Small-scale

0.647

High

884772

NOPC1
NOP protein chaperone 1

3

0

High-throughput

0.638

High

884764

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.618

High

345523

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

2

High-throughput

0.611

High

185520

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

2

9

Small-scale

0.595

High

241078

PRKN
E3 ubiquitin-protein ligase parkin

2

7

High-throughput

0.584

High

884752

KPCD1
Serine/threonine-protein kinase D1

2

1

High-throughput

0.571

High

884746

CAV1
Caveolin-1

2

0

High-throughput

0.547

High

361167

SODC
Superoxide dismutase [Cu-Zn]

1

1

High-throughput

0.536

High

371466

MYC
Myc proto-oncogene protein

1

4

High-throughput

0.536

High

374467

RASH
GTPase HRas

1

3

High-throughput

0.536

High

413408

P53
Cellular tumor antigen p53

1

3

High-throughput

0.536

High

848598

MAGA9
Melanoma-associated antigen 9

1

2

High-throughput

0.536

High

884790

UBA5
Ubiquitin-like modifier-activating enzyme 5

1

3

High-throughput

0.536

High

884806

SAR1B
Small COPII coat GTPase SAR1B

1

5

High-throughput

0.536

High

884738

TERF1
Telomeric repeat-binding factor 1

1

0

High-throughput

0.529

High

156016

SOCS6
Suppressor of cytokine signaling 6

1

1

High-throughput

0.515

High

193759

PER1
Period circadian protein homolog 1

1

1

High-throughput

0.515

High

483440

ANXA4
Annexin A4

1

4

High-throughput

0.515

High

884777

LAR4B
La-related protein 4B

1

1

High-throughput

0.515

High

884787

ZKSC3
Zinc finger protein with KRAB and SCAN domains 3

1

1

High-throughput

0.515

High

884794

RASF1
Ras association domain-containing protein 1

1

2

High-throughput

0.515

High

884805

C170B
Centrosomal protein of 170 kDa protein B

1

1

High-throughput

0.515

High

884742

SUMO2
Small ubiquitin-related modifier 2

1

7

High-throughput

0.501

High

455726

H10
Histone H1.0

1

0

High-throughput

0.493

High

552166

ADT3
ADP/ATP translocase 3

1

0

High-throughput

0.493

High

219142

LTOR5
Ragulator complex protein LAMTOR5

1

0

High-throughput

0.493

High

305832

DXO
Decapping and exoribonuclease protein

1

0

High-throughput

0.493

High

807984

CDN1A
Cyclin-dependent kinase inhibitor 1

1

0

High-throughput

0.493

High

884750

DPOA2
DNA polymerase alpha subunit B

1

0

High-throughput

0.493

High

884762

ADAL
N6-Methyl-AMP deaminase

1

0

High-throughput

0.493

High

884767

TAF8
Transcription initiation factor TFIID subunit 8

1

0

High-throughput

0.493

High

884771

PELI3
E3 ubiquitin-protein ligase pellino homolog 3

1

0

High-throughput

0.493

High

884789

ZN341
Zinc finger protein 341

1

0

High-throughput

0.493

High

884795

SRTD4
SERTA domain-containing protein 4

1

0

High-throughput

0.493

High

884802

SWP70
Switch-associated protein 70

1

0

High-throughput

0.493

High

172578

XPO1
Exportin-1

1

3

High-throughput

0.479

High

293372

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.479

High

411574

NTRK1
High affinity nerve growth factor receptor

1

6

High-throughput

0.479

High

520785

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

2

High-throughput

0.479

High

588189

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

667646

CDK2
Cyclin-dependent kinase 2

1

3

High-throughput

0.479

High

694912

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

731080

STIP1
Stress-induced-phosphoprotein 1

1

11

High-throughput

0.479

High

772110

MSX2
Homeobox protein MSX-2

1

2

High-throughput

0.479

High

830339

CCNF
Cyclin-F

1

6

High-throughput

0.479

High

884734

MCM2
DNA replication licensing factor MCM2

1

2

High-throughput

0.479

High

884735

IMA5
Importin subunit alpha-5

1

3

Small-scale

0.479

High

884736

TXTP
Tricarboxylate transport protein, mitochondrial

1

1

High-throughput

0.479

High

884737

ATX3
Ataxin-3

1

1

High-throughput

0.479

High

884743

WDR5
WD repeat-containing protein 5

1

4

High-throughput

0.479

High

884744

H31
Histone H3.1

1

4

High-throughput

0.479

High

884747

BIRC3
Baculoviral IAP repeat-containing protein 3

1

3

High-throughput

0.479

High

884748

CUL3
Cullin-3

1

9

High-throughput

0.479

High

884749

CUL4A
Cullin-4A

1

9

High-throughput

0.479

High

884751

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

884753

CL16A
Protein CLEC16A

1

2

High-throughput

0.479

High

884755

FBX43
F-box only protein 43

1

1

Small-scale

0.479

High

884757

OTU1
Ubiquitin thioesterase OTU1

1

2

High-throughput

0.479

High

884759

RN123
E3 ubiquitin-protein ligase RNF123

1

2

High-throughput

0.479

High

884770

RHG24
Rho GTPase-activating protein 24

1

2

High-throughput

0.479

High

884776

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

4

High-throughput

0.479

High

884778

CSN5
COP9 signalosome complex subunit 5

1

4

High-throughput

0.479

High

884779

CHM4C
Charged multivesicular body protein 4c

1

4

High-throughput

0.479

High

884783

DNJC2
DnaJ homolog subfamily C member 2

1

6

High-throughput

0.479

High

884784

DNJC7
DnaJ homolog subfamily C member 7

1

10

High-throughput

0.479

High

884786

SLF1
SMC5-SMC6 complex localization factor protein 1

1

4

High-throughput

0.479

High

884791

ATG5
Autophagy protein 5

1

1

High-throughput

0.479

High

884792

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

4

High-throughput

0.479

High

884800

ABCF2
ATP-binding cassette sub-family F member 2

1

7

High-throughput

0.479

High

884801

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

884803

TNIK
TRAF2 and NCK-interacting protein kinase

1

2

High-throughput

0.479

High

884807

MTCH2
Mitochondrial carrier homolog 2

1

1

High-throughput

0.479

High

884758

TET5C
Terminal nucleotidyltransferase 5C

1

0

High-throughput

0.458

High

884774

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

884775

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

884785

SH3G1
Endophilin-A2

1

0

High-throughput

0.458

High

884793

DUS21
Dual specificity protein phosphatase 21

1

0

High-throughput

0.458

High

884799

TRM7
tRNA

1

0

High-throughput

0.458

High

429521

JUN
Transcription factor Jun

1

9

High-throughput

0.445

High

529341

TAU
Microtubule-associated protein tau

1

2

High-throughput

0.445

High

619611

VCAM1
Vascular cell adhesion protein 1

1

4

High-throughput

0.445

High

884739

TERA
Transitional endoplasmic reticulum ATPase

1

6

High-throughput

0.445

High

884740

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

3

High-throughput

0.445

High

884741

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

4

High-throughput

0.445

High

884804

GAB2
GRB2-associated-binding protein 2

1

3

High-throughput

0.445

High

105568

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

124268

HAX1
HCLS1-associated protein X-1

1

1

High-throughput

0.437

High

767685

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.437

High

884756

RNFT1
E3 ubiquitin-protein ligase RNFT1

1

1

High-throughput

0.437

High

884763

LMBRL
Protein LMBR1L

1

3

High-throughput

0.437

High

884782

S45A3
Solute carrier family 45 member 3

1

1

High-throughput

0.407

High

884765

R3HCL
Coiled-coil domain-containing protein R3HCC1L

3

0

High-throughput

0.347

High

884781

DUS3L
tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like

3

0

High-throughput

0.347

High

884788

TINF2
TERF1-interacting nuclear factor 2

1

0

High-throughput

0.288

High

884796

POTE1
Protection of telomeres protein 1

1

0

High-throughput

0.288

High

66162

MET15
12S rRNA N(4)-cytidine methyltransferase METTL15

1

0

High-throughput

0.268

Low

884745

PRR3
Proline-rich protein 3

1

0

High-throughput

0.268

Low

884754

SPAS1
Spermatogenesis-associated serine-rich protein 1

1

0

High-throughput

0.268

Low

884766

SPT12
Spermatogenesis-associated protein 12

1

0

High-throughput

0.268

Low

884769

TMM61
Transmembrane protein 61

1

0

High-throughput

0.268

Low

884780

ASIC4
Acid-sensing ion channel 4

1

0

High-throughput

0.268

Low

884797

WBP1L
WW domain binding protein 1-like

1

0

High-throughput

0.268

Low

377190

SOMA
Somatotropin

1

0

High-throughput

0.249

Low

884761

BLT3A
Bridge-like lipid transfer protein family member 3A

1

0

High-throughput

0.249

Low

884773

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.249

Low

884798

MARH4
E3 ubiquitin-protein ligase MARCHF4

1

0

High-throughput

0.249

Low

261127

NSMA
Sphingomyelin phosphodiesterase 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025