HitPredict

Interactor 1: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Interactor 2: ISL1 (P61371)
Insulin gene enhancer protein ISL-1 (Islet-1)
Gene: ISL1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.55	0.60	0.576

Property	Details
Experiments	25814554, unassigned1126
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0008283 - cell population proliferation
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 304 Hs			1 349
+	Hs
		562636 PLCG2_HUMAN (1-301): 1.03e-25: 109: 15.89		ISL1_HUMAN (1-349): 1.96e-89: 274: 100.00
+	Hs
		802621 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		LHX8_HUMAN (5-77): 1.09e-09: 61.1: 21.92
+	Hs
		150515 VAV_HUMAN (11-189): 6.6e-47: 170: 28.21		ABLM1_HUMAN (2-339): 4.04e-22: 99.7: 12.87
+	Hs
		150611 Q96D37_HUMAN (11-189): 5.17e-47: 170: 28.21		ABLM1_HUMAN (2-339): 4.04e-22: 99.7: 12.87
+	Dm
		993210 GRAP_DROME (135-293): 4.02e-23: 96.4: 16.43		Q9VTW3_DROME (10-294): 8.59e-45: 162: 26.92
+	Hs
		300996 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		ABLM3_HUMAN (4-260): 1.26e-25: 109: 14.73
+	Hs
		150552 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		ABLM1_HUMAN (2-339): 4.04e-22: 99.7: 12.87
+	Hs
		924721 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		LMX1A_HUMAN (4-74): 3.59e-14: 74.6: 21.13
+	Hs
		562653 PLCG2_HUMAN (1-301): 1.03e-25: 109: 15.89		LHX8_HUMAN (5-77): 1.09e-09: 61.1: 21.92
+	Hs
		903721 ITSN1_HUMAN (150-302): 3.02e-10: 63.3: 13.87		LMO4_HUMAN (17-132): 4e-25: 101: 40.34
+	Hs
		1078873 ITSN1_HUMAN (150-302): 3.02e-10: 63.3: 13.87		LMO3_HUMAN (17-134): 2.1e-24: 98.6: 38.84