Protein: SYKC
Lysine--tRNA ligase, cytoplasmic (EC 6.1.1.6) (Lysyl-tRNA synthetase) (LysRS)

Gene: SYKC, KRS1
Organism: Saccharomyces cerevisiae S288C
Interactions: 119
UniProt ID: P15180

Gene Ontology (top 5):
GO:0000049 - tRNA binding
GO:0003729 - mRNA binding
GO:0004824 - lysine-tRNA ligase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

581879

LSM1
LSM1-LSM7 complex subunit LSM1

2

3

High-throughput

0.621

High

416189

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

13

High-throughput

0.618

High

581855

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

14

High-throughput

0.618

High

581866

RV167
Reduced viability upon starvation protein 167

2

4

High-throughput

0.611

High

581831

CDC48
Cell division control protein 48

2

5

High-throughput

0.588

High

581875

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

3

5

High-throughput

0.585

High

392148

HSP82
ATP-dependent molecular chaperone HSP82

2

7

High-throughput

0.584

High

394184

EF1A
Elongation factor 1-alpha

2

3

High-throughput

0.571

High

581821

FKBP
FK506-binding protein 1

1

2

High-throughput

0.536

High

581889

BRE5
UBP3-associated protein BRE5

1

2

High-throughput

0.536

High

581893

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

7

High-throughput

0.536

High

581825

KC11
Casein kinase I homolog 1

1

4

High-throughput

0.501

High

581826

KC12
Casein kinase I homolog 2

1

4

High-throughput

0.501

High

581884

ATG1
Serine/threonine-protein kinase ATG1

1

1

High-throughput

0.501

High

581898

STE20
Serine/threonine-protein kinase STE20

1

3

High-throughput

0.501

High

581820

PRP6
Pre-mRNA-splicing factor 6

1

3

High-throughput

0.489

High

368865

SYMC
Methionine--tRNA ligase, cytoplasmic

1

15

High-throughput

0.479

High

416077

SYTC
Threonine--tRNA ligase, cytoplasmic

1

11

High-throughput

0.479

High

438603

SC160
Protein SCP160

1

3

High-throughput

0.479

High

454149

SYH
Histidine--tRNA ligase, mitochondrial

1

3

High-throughput

0.479

High

460305

SYV
Valine--tRNA ligase, mitochondrial

1

10

High-throughput

0.479

High

464537

PBS2
MAP kinase kinase PBS2

1

2

High-throughput

0.479

High

515204

RL35A
Large ribosomal subunit protein uL29A

1

1

High-throughput

0.479

High

558551

CAF20
Cap-associated protein CAF20

1

2

High-throughput

0.479

High

560782

SYQ
Glutamine--tRNA ligase

1

14

High-throughput

0.479

High

581822

IF2A
Eukaryotic translation initiation factor 2 subunit alpha

1

3

High-throughput

0.479

High

581827

IF5A1
Eukaryotic translation initiation factor 5A-1

1

6

High-throughput

0.479

High

581828

IF2M
Translation initiation factor IF-2, mitochondrial

1

10

High-throughput

0.479

High

581830

RBSK
Ribokinase

1

2

High-throughput

0.479

High

581832

SYLC
Leucine--tRNA ligase, cytoplasmic

1

14

High-throughput

0.479

High

581834

BMH1
Protein BMH1

1

2

High-throughput

0.479

High

581835

EF1G1
Elongation factor 1-gamma 1

1

9

High-throughput

0.479

High

581836

HS104
Heat shock protein 104

1

3

High-throughput

0.479

High

581837

SP110
Spindle pole body component 110

1

4

High-throughput

0.479

High

581839

HOG1
Mitogen-activated protein kinase HOG1

1

2

High-throughput

0.479

High

581840

ZUO1
Zuotin

1

7

High-throughput

0.479

High

581841

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

2

High-throughput

0.479

High

581843

SMY2
Protein SMY2

1

2

High-throughput

0.479

High

581844

PRS6A
26S proteasome regulatory subunit 6A

1

7

High-throughput

0.479

High

581845

SPC29
Spindle pole component 29

1

1

High-throughput

0.479

High

581847

EF1G2
Elongation factor 1-gamma 2

1

7

High-throughput

0.479

High

581848

SPC42
Spindle pole body component SPC42

1

2

High-throughput

0.479

High

581849

SYYC
Tyrosine--tRNA ligase, cytoplasmic

1

5

High-throughput

0.479

High

581850

AHP1
Peroxiredoxin AHP1

1

1

High-throughput

0.479

High

581852

SYG
Glycine--tRNA ligase 1, mitochondrial

1

12

High-throughput

0.479

High

581856

YHI0
Putative proline--tRNA ligase YHR020W

1

9

High-throughput

0.479

High

581858

RPN1
26S proteasome regulatory subunit RPN1

1

4

High-throughput

0.479

High

581859

SSZ1
Ribosome-associated complex subunit SSZ1

1

4

High-throughput

0.479

High

581862

ATU2
Copper-transporting ATPase

1

2

High-throughput

0.479

High

581864

DHH1
ATP-dependent RNA helicase DHH1

1

4

High-throughput

0.479

High

581869

CCS1
Superoxide dismutase 1 copper chaperone

1

4

High-throughput

0.479

High

581870

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

2

High-throughput

0.479

High

581873

GCN20
Protein GCN20

1

6

High-throughput

0.479

High

581876

LSB3
LAS seventeen-binding protein 3

1

6

High-throughput

0.479

High

581877

SYEC
Glutamate--tRNA ligase, cytoplasmic

1

14

High-throughput

0.479

High

581878

ARC1
tRNA-aminoacylation cofactor ARC1

1

8

High-throughput

0.479

High

581880

DENR
Translation machinery-associated protein 22

1

2

High-throughput

0.479

High

581885

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

3

High-throughput

0.479

High

581886

LSB1
LAS seventeen-binding protein 1

1

5

High-throughput

0.479

High

581887

SPC98
Spindle pole body component SPC98

1

2

High-throughput

0.479

High

581888

PPID
Peptidyl-prolyl cis-trans isomerase CPR6

1

2

High-throughput

0.479

High

581890

SYC
Cysteine--tRNA ligase

1

7

High-throughput

0.479

High

581891

PDR16
Phosphatidylinositol transfer protein PDR16

1

2

High-throughput

0.479

High

581892

TMA20
Translation machinery-associated protein 20

1

2

High-throughput

0.479

High

581894

MAP1
Methionine aminopeptidase 1

1

2

High-throughput

0.479

High

581895

ESP1
Separin

1

1

High-throughput

0.479

High

581896

RLI1
Translation initiation factor RLI1

1

7

High-throughput

0.479

High

581897

TOM1
E3 ubiquitin-protein ligase TOM1

1

6

High-throughput

0.479

High

581900

RUVB1
RuvB-like protein 1

1

2

High-throughput

0.479

High

581903

RM34
Large ribosomal subunit protein bL34m

1

2

High-throughput

0.479

High

581906

LAM6
Membrane-anchored lipid-binding protein LAM6

1

1

High-throughput

0.479

High

581911

TRMB
tRNA

1

2

High-throughput

0.479

High

581912

MLH3
DNA mismatch repair protein MLH3

1

2

High-throughput

0.479

High

581916

MDY2
Ubiquitin-like protein MDY2

1

2

High-throughput

0.479

High

581917

DBP10
ATP-dependent RNA helicase DBP10

1

8

High-throughput

0.479

High

364301

CDK1
Cyclin-dependent kinase 1

1

0

High-throughput

0.458

High

581846

IF4B
Eukaryotic translation initiation factor 4B

1

0

High-throughput

0.458

High

581882

SKP1
Suppressor of kinetochore protein 1

1

0

Small-scale

0.458

High

581904

CYK2
Cytokinesis protein 2

1

0

High-throughput

0.458

High

581868

SSB2
Ribosome-associated molecular chaperone SSB2

1

6

High-throughput

0.445

High

394021

EFTU
Elongation factor Tu, mitochondrial

1

10

High-throughput

0.437

High

451989

TOM70
Mitochondrial import receptor subunit TOM70

1

8

High-throughput

0.437

High

581818

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial

1

2

High-throughput

0.437

High

581819

IF5A2
Eukaryotic translation initiation factor 5A-2

1

6

High-throughput

0.437

High

581823

ATP5E
ATP synthase subunit epsilon, mitochondrial

1

2

High-throughput

0.437

High

581829

SIS1
Protein SIS1

1

3

High-throughput

0.437

High

581833

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.437

High

581838

MET4
Transcriptional activator of sulfur metabolism MET4

1

2

High-throughput

0.437

High

581842

TIM23
Mitochondrial import inner membrane translocase subunit TIM23

1

2

High-throughput

0.437

High

581851

RM16
Large ribosomal subunit protein uL16m

1

2

High-throughput

0.437

High

581860

RPN10
26S proteasome regulatory subunit RPN10

1

2

High-throughput

0.437

High

581861

SEC31
Protein transport protein SEC31

1

9

High-throughput

0.437

High

581863

CAJ1
Protein CAJ1

1

3

High-throughput

0.437

High

581865

LAA1
AP-1 accessory protein LAA1

1

2

High-throughput

0.437

High

581867

SIT1
Siderophore iron transporter 1

1

6

High-throughput

0.437

High

581871

DSN1
Kinetochore-associated protein DSN1

1

1

High-throughput

0.437

High

581872

MMM1
Maintenance of mitochondrial morphology protein 1

1

2

High-throughput

0.437

High

581874

EMP47
Protein EMP47

1

1

High-throughput

0.437

High

581881

HOSC
Homocitrate synthase, cytosolic isozyme

1

3

High-throughput

0.437

High

581899

YMC0
Uncharacterized protein YML020W

1

2

High-throughput

0.437

High

581902

RPN9
26S proteasome regulatory subunit RPN9

1

1

High-throughput

0.437

High

581905

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

2

High-throughput

0.437

High

581907

ENB1
Siderophore iron transporter ENB1

1

6

High-throughput

0.437

High

581908

TIM18
Mitochondrial import inner membrane translocase subunit TIM18

1

2

High-throughput

0.437

High

581909

AP3D
AP-3 complex subunit delta

1

2

High-throughput

0.437

High

581914

RRP6
Exosome complex exonuclease RRP6

1

2

High-throughput

0.437

High

581918

EMC6
ER membrane protein complex subunit 6

1

2

High-throughput

0.437

High

581919

RKM4
Ribosomal lysine N-methyltransferase 4

1

2

High-throughput

0.437

High

581920

MED11
Mediator of RNA polymerase II transcription subunit 11

1

2

High-throughput

0.437

High

581910

TFB4
General transcription and DNA repair factor IIH subunit TFB4

2

0

High-throughput

0.324

High

581824

ATP12
Protein ATP12, mitochondrial

1

0

High-throughput

0.249

Low

581853

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

581854

PHO88
SRP-independent targeting protein 3

1

0

High-throughput

0.249

Low

581857

GOSR1
Golgi SNAP receptor complex member 1

1

0

High-throughput

0.249

Low

581883

TPN1
Vitamin B6 transporter TPN1

1

0

High-throughput

0.249

Low

581901

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.249

Low

581913

ATG9
Autophagy-related protein 9

1

0

High-throughput

0.249

Low

581915

MDM32
Mitochondrial distribution and morphology protein 32

1

0

High-throughput

0.249

Low

581921

ENV10
SRP-independent targeting protein 2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025