HitPredict

Interactor 1: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Interactor 2: FLNC (Q14315)
Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin)
Gene: FLNC

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	17474147
Identification Methods	peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0008092 - cytoskeletal protein binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 304 Hs			1 2725
+	Hs
		581006 PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39		FLNC_HUMAN (1-2725): 0: 2507: 100.00
+	Hs
		924572 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		FLNC_HUMAN (1-2725): 0: 2507: 100.00
+	Hs
		597997 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		FLNA_HUMAN (167-2725): 0: 1226: 35.27
+	Hs
		261219 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		FLNB_HUMAN (146-2725): 0: 1198: 35.18
+	Hs
		580922 PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39		FLNA_HUMAN (167-2725): 0: 1226: 35.27
+	Mm
		1207250 PLCG2_MOUSE (11-301): 1.34e-25: 108: 16.40		FLNA_MOUSE (138-2725): 0: 1226: 34.95
+	Hs
		598047 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		FLNA_HUMAN (167-2725): 0: 1226: 35.27
+	Hs
		261197 PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39		FLNB_HUMAN (146-2725): 0: 1198: 35.18
+	Hs
		261240 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		FLNB_HUMAN (146-2725): 0: 1198: 35.18
+	Hs
		521521 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		ACTN1_HUMAN (13-382): 6.48e-123: 414: 26.30
+	Hs
		211557 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		ACTN4_HUMAN (16-387): 7.58e-120: 406: 26.68
+	Mm
		1143722 PLCG2_MOUSE (11-301): 1.34e-25: 108: 16.40		SPTB2_MOUSE (26-266): 1.26e-100: 365: 38.12
+	Hs
		924482 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		SPTB2_HUMAN (26-266): 1.26e-100: 365: 38.12
+	Ce
		666217 SEM5_CAEEL (135-291): 6.58e-25: 101: 14.83		Q23158_CAEEL (16-315): 1.14e-104: 361: 28.93
+	Hs
		924478 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		PGBM_HUMAN (1306-2725): 4.84e-73: 276: 11.87
+	Mm
		506793 PLCG2_MOUSE (11-301): 1.34e-25: 108: 16.40		FINC_MOUSE (442-1887): 1.14e-70: 267: 12.46
+	Hs
		363045 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		FINC_HUMAN (1545-2724): 1.85e-65: 250: 13.83
+	Ce
		136804 VAV_CAEEL (13-194): 4.87e-22: 98.4: 23.94		UNC89_CAEEL (406-2706): 4.03e-33: 144: 10.48
+	Ce
		87662 Q9U2T9_CAEEL (182-300): 9.9e-11: 64.7: 13.22		D0IMZ5_CAEEL (2126-2724): 6.74e-26: 120: 18.59
+	Hs
		855816 VAV2_HUMAN (2-191): 3.44e-29: 119: 19.74		TITIN_HUMAN (1554-2636): 3.13e-09: 65.5: 10.78