Protein: SYDC
Aspartate--tRNA ligase, cytoplasmic (EC 6.1.1.12) (Aspartyl-tRNA synthetase) (AspRS)

Gene: SYDC, DPS1
Organism: Saccharomyces cerevisiae S288C
Interactions: 133
UniProt ID: P04802

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0004815 - aspartate-tRNA ligase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

391954

HSP82
ATP-dependent molecular chaperone HSP82

3

7

High-throughput

0.654

High

416254

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

3

4

High-throughput

0.640

High

416189

SYKC
Lysine--tRNA ligase, cytoplasmic

1

13

High-throughput

0.618

High

416230

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

13

High-throughput

0.618

High

416206

HS104
Heat shock protein 104

2

4

High-throughput

0.584

High

394079

EF1A
Elongation factor 1-alpha

2

3

High-throughput

0.571

High

416185

SSB1
Ribosome-associated molecular chaperone SSB1

2

5

High-throughput

0.571

High

416233

SSZ1
Ribosome-associated complex subunit SSZ1

2

4

High-throughput

0.571

High

416212

SLA1
Actin cytoskeleton-regulatory complex protein SLA1

1

4

High-throughput

0.541

High

416178

PYR1
Multifunctional protein URA2

1

4

High-throughput

0.536

High

416193

PRP6
Pre-mRNA-splicing factor 6

1

3

High-throughput

0.536

High

416227

IMB2
Importin subunit beta-2

1

2

High-throughput

0.536

High

416250

MPG1
Mannose-1-phosphate guanyltransferase

1

1

High-throughput

0.536

High

416275

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

7

High-throughput

0.536

High

416198

SIS1
Protein SIS1

1

3

High-throughput

0.515

High

416175

KAPA
cAMP-dependent protein kinase type 1

1

2

High-throughput

0.501

High

416182

SPS1
Sporulation-specific protein 1

1

1

High-throughput

0.501

High

416196

NPR1
Nitrogen permease reactivator protein

1

3

High-throughput

0.501

High

416215

PRP40
Pre-mRNA-processing protein PRP40

1

1

High-throughput

0.501

High

416238

AURK
Aurora kinase

1

2

High-throughput

0.501

High

416258

SET2
Histone-lysine N-methyltransferase, H3 lysine-36 specific

1

4

High-throughput

0.501

High

416267

PDK2
[Pyruvate dehydrogenase

1

3

High-throughput

0.501

High

416280

SKY1
Serine/threonine-protein kinase SKY1

1

3

High-throughput

0.501

High

416241

SAW1
Single-strand annealing weakened protein 1

1

0

High-throughput

0.493

High

416172

CDC25
Cell division control protein 25

1

0

High-throughput

0.480

High

416224

AKL1
Serine/threonine-protein kinase AKL1

1

0

High-throughput

0.480

High

368844

SYMC
Methionine--tRNA ligase, cytoplasmic

1

15

High-throughput

0.479

High

399322

CARB
Carbamoyl phosphate synthase arginine-specific large chain

1

4

High-throughput

0.479

High

416058

SYTC
Threonine--tRNA ligase, cytoplasmic

1

10

High-throughput

0.479

High

416173

RL26A
Large ribosomal subunit protein uL24A

1

2

High-throughput

0.479

High

416174

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.479

High

416179

SYH
Histidine--tRNA ligase, mitochondrial

1

3

High-throughput

0.479

High

416180

RS19A
Small ribosomal subunit protein eS19A

1

2

High-throughput

0.479

High

416181

SYV
Valine--tRNA ligase, mitochondrial

1

10

High-throughput

0.479

High

416186

CAF20
Cap-associated protein CAF20

1

2

High-throughput

0.479

High

416187

SYQ
Glutamine--tRNA ligase

1

14

High-throughput

0.479

High

416188

HSC82
ATP-dependent molecular chaperone HSC82

1

7

High-throughput

0.479

High

416192

IF5A2
Eukaryotic translation initiation factor 5A-2

1

6

High-throughput

0.479

High

416194

IF2A
Eukaryotic translation initiation factor 2 subunit alpha

1

3

High-throughput

0.479

High

416197

IF5A1
Eukaryotic translation initiation factor 5A-1

1

6

High-throughput

0.479

High

416199

RBSK
Ribokinase

1

2

High-throughput

0.479

High

416200

RS2
Small ribosomal subunit protein uS5

1

2

High-throughput

0.479

High

416201

CDC48
Cell division control protein 48

1

5

High-throughput

0.479

High

416202

SYLC
Leucine--tRNA ligase, cytoplasmic

1

14

High-throughput

0.479

High

416203

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

416204

BMH1
Protein BMH1

1

2

High-throughput

0.479

High

416205

EF1G1
Elongation factor 1-gamma 1

1

9

High-throughput

0.479

High

416207

SP110
Spindle pole body component 110

1

4

High-throughput

0.479

High

416208

MET4
Transcriptional activator of sulfur metabolism MET4

1

2

High-throughput

0.479

High

416209

HOG1
Mitogen-activated protein kinase HOG1

1

2

High-throughput

0.479

High

416210

ZUO1
Zuotin

1

5

High-throughput

0.479

High

416214

SMY2
Protein SMY2

1

2

High-throughput

0.479

High

416216

PRS6A
26S proteasome regulatory subunit 6A

1

7

High-throughput

0.479

High

416218

RS3A1
Small ribosomal subunit protein eS1A

1

1

High-throughput

0.479

High

416219

RS27A
Small ribosomal subunit protein eS27A

1

2

High-throughput

0.479

High

416220

EF1G2
Elongation factor 1-gamma 2

1

7

High-throughput

0.479

High

416221

SPC42
Spindle pole body component SPC42

1

2

High-throughput

0.479

High

416222

SYYC
Tyrosine--tRNA ligase, cytoplasmic

1

5

High-throughput

0.479

High

416225

SYG
Glycine--tRNA ligase 1, mitochondrial

1

12

High-throughput

0.479

High

416229

RS20
Small ribosomal subunit protein uS10

1

2

High-throughput

0.479

High

416231

YHI0
Putative proline--tRNA ligase YHR020W

1

9

High-throughput

0.479

High

416232

RPN1
26S proteasome regulatory subunit RPN1

1

4

High-throughput

0.479

High

416235

RPN10
26S proteasome regulatory subunit RPN10

1

2

High-throughput

0.479

High

416236

IF1A
Eukaryotic translation initiation factor 1A

1

1

High-throughput

0.479

High

416239

DHH1
ATP-dependent RNA helicase DHH1

1

4

High-throughput

0.479

High

416240

LAA1
AP-1 accessory protein LAA1

1

2

High-throughput

0.479

High

416245

CCS1
Superoxide dismutase 1 copper chaperone

1

4

High-throughput

0.479

High

416246

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

2

High-throughput

0.479

High

416248

DSN1
Kinetochore-associated protein DSN1

1

1

High-throughput

0.479

High

416252

GCN20
Protein GCN20

1

6

High-throughput

0.479

High

416255

LSB3
LAS seventeen-binding protein 3

1

5

High-throughput

0.479

High

416256

SYEC
Glutamate--tRNA ligase, cytoplasmic

1

14

High-throughput

0.479

High

416257

ARC1
tRNA-aminoacylation cofactor ARC1

1

8

High-throughput

0.479

High

416259

DENR
Translation machinery-associated protein 22

1

2

High-throughput

0.479

High

416260

HOSC
Homocitrate synthase, cytosolic isozyme

1

3

High-throughput

0.479

High

416261

RS12
Small ribosomal subunit protein eS12

1

2

High-throughput

0.479

High

416269

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

2

High-throughput

0.479

High

416270

SPC98
Spindle pole body component SPC98

1

2

High-throughput

0.479

High

416271

PPID
Peptidyl-prolyl cis-trans isomerase CPR6

1

2

High-throughput

0.479

High

416272

PDR16
Phosphatidylinositol transfer protein PDR16

1

2

High-throughput

0.479

High

416274

TMA20
Translation machinery-associated protein 20

1

2

High-throughput

0.479

High

416276

RS15
Small ribosomal subunit protein uS19

1

2

High-throughput

0.479

High

416277

ESP1
Separin

1

1

High-throughput

0.479

High

416278

RLI1
Translation initiation factor RLI1

1

7

High-throughput

0.479

High

416279

TOM1
E3 ubiquitin-protein ligase TOM1

1

7

High-throughput

0.479

High

416282

RM34
Large ribosomal subunit protein bL34m

1

2

High-throughput

0.479

High

416283

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

2

High-throughput

0.479

High

416284

IRC20
Uncharacterized ATP-dependent helicase IRC20

1

3

Small-scale

0.479

High

416286

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.479

High

416288

RS10A
Small ribosomal subunit protein eS10A

1

2

High-throughput

0.479

High

416291

TRMB
tRNA

1

2

High-throughput

0.479

High

416293

RRP6
Exosome complex exonuclease RRP6

1

1

High-throughput

0.479

High

416294

MDY2
Ubiquitin-like protein MDY2

1

2

High-throughput

0.479

High

416295

DBP10
ATP-dependent RNA helicase DBP10

1

7

High-throughput

0.479

High

416297

RKM4
Ribosomal lysine N-methyltransferase 4

1

2

High-throughput

0.479

High

416298

MED11
Mediator of RNA polymerase II transcription subunit 11

1

2

High-throughput

0.479

High

416263

SC6B1
Protein transport protein SBH1

1

0

Small-scale

0.460

High

416292

NOP53
Ribosome biogenesis protein NOP53

1

0

High-throughput

0.460

High

416176

TYSY
Thymidylate synthase

1

0

High-throughput

0.458

High

416183

RL18B
Large ribosomal subunit protein eL18B

1

0

High-throughput

0.458

High

416226

ADH5
Alcohol dehydrogenase 5

1

0

High-throughput

0.458

High

416242

SS120
Protein SSP120

1

0

High-throughput

0.458

High

416184

HSP71
Heat shock protein SSA1

1

2

High-throughput

0.445

High

416190

VATB
V-type proton ATPase subunit B

1

1

High-throughput

0.445

High

416211

HSP7F
Heat shock protein homolog SSE1

1

5

High-throughput

0.445

High

416217

PRS7
26S proteasome regulatory subunit 7 homolog

1

11

High-throughput

0.445

High

416244

SSB2
Ribosome-associated molecular chaperone SSB2

1

5

High-throughput

0.445

High

416285

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

4

High-throughput

0.445

High

416234

YHS2
MIP18 family protein YHR122W

1

0

High-throughput

0.438

High

416177

TOM70
Mitochondrial import receptor subunit TOM70

1

7

High-throughput

0.437

High

416195

ATP5E
ATP synthase subunit epsilon, mitochondrial

1

2

High-throughput

0.437

High

416213

TIM23
Mitochondrial import inner membrane translocase subunit TIM23

1

3

High-throughput

0.437

High

416223

RM16
Large ribosomal subunit protein uL16m

1

2

High-throughput

0.437

High

416237

SEC31
Protein transport protein SEC31

1

9

High-throughput

0.437

High

416243

SIT1
Siderophore iron transporter 1

1

5

High-throughput

0.437

High

416249

MMM1
Maintenance of mitochondrial morphology protein 1

1

2

High-throughput

0.437

High

416251

SET4
SET domain-containing protein 4

1

3

Small-scale

0.437

High

416253

EMP47
Protein EMP47

1

1

High-throughput

0.437

High

416268

EIF2A
Eukaryotic translation initiation factor 2A

1

2

High-throughput

0.437

High

416273

SAM50
Sorting assembly machinery 50 kDa subunit

1

1

High-throughput

0.437

High

416281

YMC0
Uncharacterized protein YML020W

1

2

High-throughput

0.437

High

416287

ENB1
Siderophore iron transporter ENB1

1

5

High-throughput

0.437

High

416289

TIM18
Mitochondrial import inner membrane translocase subunit TIM18

1

2

High-throughput

0.437

High

416290

AP3D
AP-3 complex subunit delta

1

2

High-throughput

0.437

High

416296

EMC6
ER membrane protein complex subunit 6

1

2

High-throughput

0.437

High

416299

ODC2
Mitochondrial 2-oxodicarboxylate carrier 2

1

1

High-throughput

0.437

High

416191

APA1
Protein APA1 [Includes: Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase 1

1

0

High-throughput

0.426

High

416264

SCS3
Acyl-coenzyme A diphosphatase SCS3

1

0

Small-scale

0.251

Low

416228

YBU6
Probable thioesterase YBR096W

1

0

High-throughput

0.249

Low

416247

FIS1
Mitochondrial fission 1 protein

1

0

Small-scale

0.249

Low

416262

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low

416265

YGO0
Uncharacterized membrane protein YGL140C

1

0

High-throughput

0.249

Low

416266

MTHR2
Methylenetetrahydrofolate reductase 2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025