HitPredict

Interactor 1: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Interactor 2: LIPB2 (Q8ND30)
Liprin-beta-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2) (PTPRF-interacting protein-binding protein 2)
Gene: PPFIBP2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.678

Property	Details
Experiments	26871637, 33961781, 19447967
Identification Methods	two hybrid, affinity chromatography technology, two hybrid array, two hybrid pooling approach, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 304 Hs			1 876
+	Hs
		802874 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		LIPB2_HUMAN (1-876): 1.36e-162: 498: 100.00
+	Hs
		1203004 SH3K1_HUMAN (114-192): 4.08e-10: 62.5: 22.22		LIPB1_HUMAN (1-875): 2.93e-95: 323: 40.56
+	Hs
		1191815 CD2AP_HUMAN (1-196): 4.74e-12: 68.3: 17.12		ANS1B_HUMAN (293-850): 5.44e-63: 233: 14.31
+	Hs
		209098 NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00		ANS1B_HUMAN (293-850): 5.44e-63: 233: 14.31
+	Mm
		1206702 ITSN1_MOUSE (143-302): 6.55e-13: 71.4: 10.98		ANS1B_MOUSE (293-850): 2.15e-58: 219: 14.66
+	Hs
		1268522 CD2AP_HUMAN (1-196): 4.74e-12: 68.3: 17.12		ANS1A_HUMAN (273-850): 4.73e-57: 215: 16.50
+	Hs
		1268487 SH3K1_HUMAN (114-192): 4.08e-10: 62.5: 22.22		ANS1A_HUMAN (273-850): 4.73e-57: 215: 16.50
+	Hs
		1115812 SH3K1_HUMAN (114-192): 4.08e-10: 62.5: 22.22		Q49AR9_HUMAN (547-850): 1.99e-59: 214: 20.00
+	Hs
		259657 PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39		LIPA4_HUMAN (2-356): 5.67e-09: 62.4: 12.64
+	Hs
		728465 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		MYH11_HUMAN (106-374): 5.78e-09: 62.2: 23.31
+	Hs
		259644 ITSN1_HUMAN (150-302): 3.02e-10: 63.3: 13.87		LIPA2_HUMAN (62-564): 5.06e-11: 68.9: 12.03